Additive manufacturing and its societal impact: a literature review

Huang, Samuel H.; Liu, Peng; Mokasdar, Abhiram; Hou, Liang

doi:10.1007/s00170-012-4558-5

Cited by 1,512 publications

(921 citation statements)

References 35 publications

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“…Powderspecialised facilities with potential wastage are less suitable for small-scale production in a community or hospital pharmacies (Huang et al, 2013).…”

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confidence: 99%

Adaptation of pharmaceutical excipients to FDM 3D printing for the fabrication of patient-tailored immediate release tablets

Sadia

Sośnicka

Arafat

et al. 2016

International Journal of Pharmaceutics

272

147

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Abstract*Corresponding author: MAlbedAlhnan@uclan.ac.uk This work aims to employ fused deposition modelling 3D printing to fabricate immediate release pharmaceutical tablets with various model drugs. It investigates the addition of nonmelting filler to methacrylic matrix to facilitate FDM 3D printing and explore the impact of i) the nature of filler, ii) compatibility with the gears of the 3D printer and, and iii) polymer: filler ratio on the 3D printing process. A specially developed filament based on pharmaceutically approved methacrylic polymer (Eudragit E) and thermally stable filler, TCP (tribasic calcium phosphate) was optimised. Four model drugs (with different physicochemical properties were included into ready-to-use mechanically stable tablets with immediate release properties. Amongst the investigated fillers in this work, directly compressible lactose, spray-dried lactose and microcrystalline cellulose showed a level of degradation at 135 o C whilst talc and TCP allowed consistent flow of the filament and a successful 3D printing of the tablet. Following the two thermal processes (hot melt extrusion (HME) and fused deposition modelling (FDM) 3D printing), drug contents were 94.22%, 88.53%, 96.51% and 93.04% for 5-ASA, captopril, theophylline and prednisolone respectively. XRPD indicated that a fraction of 5-ASA, theophylline and prednisolone remained in the crystalline form whilst captopril was in amorphous form. By combining the advantages of thermally stable pharmaceutically approved polymers and fillers, this unique approach provides a low cost production method for on demand manufacturing of individualised dosage forms.

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“…Powderspecialised facilities with potential wastage are less suitable for small-scale production in a community or hospital pharmacies (Huang et al, 2013).…”

mentioning

confidence: 99%

Adaptation of pharmaceutical excipients to FDM 3D printing for the fabrication of patient-tailored immediate release tablets

Sadia

Sośnicka

Arafat

et al. 2016

International Journal of Pharmaceutics

272

147

View full text Add to dashboard Cite

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“…These processes have been optimised over a number of decades resulting in implants that can withstand long-term cyclic loading. In recent years, the use of additive manufacturing (AM) techniques in medicine has gained much attention [17], [18], [19], [20] and [21]. Generally, AM techniques use a layer-by-layer approach to build parts from computer aided design (CAD) models.…”

mentioning

confidence: 99%

Adding functionality with additive manufacturing: Fabrication of titanium-based antibiotic eluting implants

Cox

Jamshidi

Eisenstein

et al. 2016

Materials Science and Engineering: C

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Additive manufacturing technologies have been utilised in healthcare to create patient-specific implants. This study demonstrates the potential to add new implant functionality by further exploiting the design flexibility of these technologies. Selective laser melting was used to manufacture titanium-based (Ti-6Al-4V) implants containing a reservoir. Pore channels, connecting the implant surface to the reservoir, were incorporated to facilitate antibiotic delivery. An injectable brushite, calciumphosphate cement, was formulated as a carrier vehicle for gentamicin. Incorporation of the antibiotic significantly (p=0.01) improved the compressive strength (5.8± 0.7 MPa) of the cement compared to non-antibiotic samples. The controlled release of gentamicin sulphate from the calcium phosphate cement injected into the implant reservoir was demonstrated in short term elution studies using ultraviolet visible spectroscopy. Orientation of the implant pore channels were shown, using micro-computed tomography, to impact design reproducibility and the back-pressure generated during cement injection which ultimately altered porosity. The amount of antibiotic released from all implant designs over a 6 hour period (b28% of the total amount) were found to exceed the minimum inhibitory concentrations of Staphylococcus aureus (16 μg/mL) and Staphylococcus epidermidis (1 μg/mL); two bacterial species commonly associated with periprosthetic infections. Antibacterial efficacy was confirmed against both bacterial cultures using an agar diffusion assay. Interestingly, pore channel orientation was shown to influence the directionality of inhibition zones. Promisingly, this work demonstrates the potential to additively manufacture a titanium-based antibiotic eluting implant, which is an attractive alternative to current treatment strategies of periprosthetic infections.

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“…Material (Bourell et al, 2009 Figura 6 -Foto esquemática do sistema baseado em pó e laser de Ciraud (Baldock, 2016) Nos anos 80, computadores, lasers, placas controladoras e muitas outras tecnologias haviam atingido um grau de sofisticação tal que passou a ser possível criar equipamentos capazes de concretizar os modelos dos anos anteriores de forma física (O'Connor, 2014 Systems, visando à produção desse novo equipamento (Baldock, 2016;Bechthold et al, 2015;Huang et al, 2013;Klein et al, 2015;Mackley, 2014;Maxwell, 2012;O'Connor, 2014;Paben e Stephens, 2015;Ray, 2013;Zhai et al, 2014 Figura 7 -Ilustração do processo proposto por Hull em sua patente (Hull, 1986) Concomitante à estereolitografia de Hull, Carl R. Deckard, graduando da universidade do Texas, apresentou ao mundo sua tecnologia Selective Laser Sintering (SLS), que se tornaria em uma das principais tecnologias de AM até os dias atuais (Paben e Stephens, 2015). Deckard preencheu em 1986 sua patente intitulada: "Método e equipamento para produção de peças por sinterização seletiva", tecnologia que permitiu o uso na AM de materiais que não apenas polímeros, tais quais metais, termoplásticos, cerâmicas, além de poder utilizar, também, polímeros de diversas naturezas (Bechthold et al, 2015;Deckard, 1989;Mackley, 2014;Strickland, 2016 (Santos et al, 2006).…”

Section: Antecedentesunclassified

“…Em seu catálogo, a Boeing conta com mais de 300 peças fabricadas por AM, aplicadas em pelo menos 10 modelos de aeronaves distintos, tendo disponibilizado ao mercado mais de 22.000 componentes individuais para aeronaves (Cunningham et al, 2015;Huang et al, 2013; Zimmerman e Allen III, 2013).…”

Section: Boeingunclassified

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Potencial Disruptivo Da Manufatura Aditiva: Influência Nas Cadeias De Suprimentos E Uma Aplicação Na Marinha Do Brasil

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Additive manufacturing and its societal impact: a literature review

Cited by 1,512 publications

References 35 publications

Adaptation of pharmaceutical excipients to FDM 3D printing for the fabrication of patient-tailored immediate release tablets

Adaptation of pharmaceutical excipients to FDM 3D printing for the fabrication of patient-tailored immediate release tablets

Adding functionality with additive manufacturing: Fabrication of titanium-based antibiotic eluting implants

Potencial Disruptivo Da Manufatura Aditiva: Influência Nas Cadeias De Suprimentos E Uma Aplicação Na Marinha Do Brasil

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