Additive manufacturing of PLA-based scaffolds intended for bone regeneration and strategies to improve their biological properties

Donate, Ricardo; Monzón, Mario; Alemán‐Domínguez, María Elena

doi:10.1515/epoly-2020-0046

Cited by 101 publications

(61 citation statements)

References 199 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In recent years, three‐dimensional (3D) printing has become an attractive method for the creation of porous PLA scaffolds with high mechanical strength 76,90,92–99 . 3D printing is based on a continuous extrusion of melted materials through a micro nozzle by an air‐pressure, piston‐assisted or screw‐assisted system 97,100 . Gregor et al 94 successfully fabricated PLA scaffolds with an average pore diameter of 350 μm for bone tissue engineering.…”

Section: Methods For Pla Processingmentioning

confidence: 99%

Section: Methods For Pla Processingmentioning

confidence: 99%

“…The technique is cost‐effective, flexible, and easily feasible, but also allows controlled porosity and pore size 90,97 . Donate et al 97 produced PLA scaffolds with 90% porosity and compression modulus of 70 MPa. Also, PLA scaffolds with a pore size of 800 μm and porosity of 70%–75% were obtained by applying the same technique 106 …”

Section: Methods For Pla Processingmentioning

confidence: 99%

See 2 more Smart Citations

Tailoring of advanced poly(lactic acid)‐based materials: A review

Milovanović

Pajnik

Lukić

2021

J of Applied Polymer Sci

View full text Add to dashboard Cite

Poly(lactic acid) (PLA) stands out as the most promising biodegradable alternative to conventional petrochemical‐based polymers for manufacturing of high‐performance materials applied in medicine, pharmacy, food, textile, and electronic industry. This review was aimed to present the conventional and up‐to‐date technologies for PLA processing including melt blending and molding, hot melt extrusion, 3D printing, foaming, impregnation, thermally induced phase separation, nano‐ and microparticles preparation, wet and dry spinning processes. In addition, the effect of the processing parameters and polymer characteristics on the properties of the final material was elaborated. Diverse possibilities to tailor properties of PLA‐based materials by variation in polymer characteristics and concentration, solvent selection, drying method, processing pressure and temperature, incorporation of bioactive components, and so on were highlighted. The examples of the relations between processing methods, parameters, and end‐product properties are given for a better understanding of all aspects that need to be perceived for fabrication of PLA‐based materials with required performances.

show abstract

Section: Methods For Pla Processingmentioning

confidence: 99%

Section: Methods For Pla Processingmentioning

confidence: 99%

Section: Methods For Pla Processingmentioning

confidence: 99%

See 1 more Smart Citation

Tailoring of advanced poly(lactic acid)‐based materials: A review

Milovanović

Pajnik

Lukić

2021

J of Applied Polymer Sci

View full text Add to dashboard Cite

show abstract

“…Melt-based technologies offer the possibility to avoid the use of organic solvents that can elicit cytotoxic effects on the final structure. However, melt-based methods normally produce constructs exhibiting a porosity lower than the range recommended in the literature for TE applications (i.e., lower than 80%) [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Solution-Based Processing for Scaffold Fabrication in Tissue Engineering Applications: A Brief Review

et al. 2021

View full text Add to dashboard Cite

The fabrication of 3D scaffolds is under wide investigation in tissue engineering (TE) because of its incessant development of new advanced technologies and the improvement of traditional processes. Currently, scientific and clinical research focuses on scaffold characterization to restore the function of missing or damaged tissues. A key for suitable scaffold production is the guarantee of an interconnected porous structure that allows the cells to grow as in native tissue. The fabrication techniques should meet the appropriate requirements, including feasible reproducibility and time- and cost-effective assets. This is necessary for easy processability, which is associated with the large range of biomaterials supporting the use of fabrication technologies. This paper presents a review of scaffold fabrication methods starting from polymer solutions that provide highly porous structures under controlled process parameters. In this review, general information of solution-based technologies, including freeze-drying, thermally or diffusion induced phase separation (TIPS or DIPS), and electrospinning, are presented, along with an overview of their technological strategies and applications. Furthermore, the differences in the fabricated constructs in terms of pore size and distribution, porosity, morphology, and mechanical and biological properties, are clarified and critically reviewed. Then, the combination of these techniques for obtaining scaffolds is described, offering the advantages of mimicking the unique architecture of tissues and organs that are intrinsically difficult to design.

show abstract

“…The polymer as the main component in the powder feedstock is melted through the laser irradiation giving as result the printed polymer/ceramic composite scaffold. Since these polymers are not removed after the PBSLP process, the time of implantation can have some adverse effects, thus losing some of their properties or affecting negatively to the tissue regeneration [6].…”

Section: Introductionmentioning

confidence: 99%

Powder bed selective laser process (sintering/melting) applied to tailored calcium phosphate-based powders

Navarrete-Segado¹,

Francès²,

Tourbin³

et al. 2021

Preprint

View full text Add to dashboard Cite

This paper focuses on the tailoring of calcium phosphate powders for their use as powder bed selective laser process feedstock. Hydroxyapatite and chlorapatite were used as starting powders for the preparation of different blends through the addition of graphite as a laser absorptance additive. A methodical study was conducted to compare the processing windows of the blends containing different amounts of graphite through the laser patterning of circular samples. It was found that the addition of graphite increases the process window of the powder blends being the powder without additive non processable. Hydroxyapatite showed a clear phase transition (decreased when using higher volumetric energy density) into other calcium phosphate phases while chlorapatite was demonstrated to be thermally stable during the whole process (examined through X-ray diffraction and vibrational spectroscopies). In parallel, the study evaluating the powder blend composed of hydroxyapatite and graphite for the production of solid and complex parts was carried out although it required long printing times. The productivity of the process was improved by modification of printing parameters. Then, a series of solid samples were produced for the analysis of the microstructure and mechanical properties. High interconnected porosity was observed in the samples which could improve the bioactivity of the bioceramic scaffolds. A post-treatment of the parts increased their proportion in the hydroxyapatite phase and their mechanical properties. These results are expected to contribute to the application of powder bed selective laser processing of calcium phosphates powders toward bone tissue engineering.

show abstract

Additive manufacturing of PLA-based scaffolds intended for bone regeneration and strategies to improve their biological properties

Cited by 101 publications

References 199 publications

Tailoring of advanced poly(lactic acid)‐based materials: A review

Tailoring of advanced poly(lactic acid)‐based materials: A review

Solution-Based Processing for Scaffold Fabrication in Tissue Engineering Applications: A Brief Review

Powder bed selective laser process (sintering/melting) applied to tailored calcium phosphate-based powders

Contact Info

Product

Resources

About