We consider (Frobenius) difference equations over (Fq(s, t), φq) where φq fixes t and acts on Fq(s) as the Frobenius endomorphism. We prove that every semisimple, simplyconnected linear algebraic group G defined over Fq can be realized as a difference Galois group over (F q i(s, t), φ q i ) for some i ∈ N. The proof uses upper and lower bounds on the Galois group scheme of a Frobenius difference equation that are developed in this paper. The result can be seen as a difference analogue of Nori's Theorem which states that G(Fq) occurs as (finite) Galois group over Fq(s).