Additive Role of a Potentially Reversible Cognitive Frailty Model and Inflammatory State on the Risk of Disability: The Italian Longitudinal Study on Aging

Lozupone, Madia; Seripa, Davide; Giannini, Michele; Sardone, Rodolfo; Bonfiglio, Caterina; Abbrescia, Daniela Isabel; Gandin, Claudia; Daniele, Antonio; Sabbá, Carlo; Logroscino, Giancarlo; Scafato, Emanuele; Farchi, G; Galluzzo, Lucia; Gandin, Claudia; Capurso, Antonio; Panza, Francesco; Solfrizzi, Vincenzo; Lepore, Vito; Livrea, Paolo; Motta, Luciano; Carnazzo, G.; Motta, Massimo; Bentivegna, Prospera; Bonaiuto, S.; Cruciani, Guido; Postacchini, Demetrio; Inzitari, Domenico; Amaducci, L.; Carlo, Antonio Di; Baldereschi, Marzia; Gandolfo, Carlo; Conti, Massimo; Canal, N.; Franceschi, M.; Scarlato, G.; Candelise, Livia; Scapini, Elio; Rengo, Franco; Abete, Pasquale; Cacciatore, Francesco; Enzi, Giuliano; Battistin, Leontino; Sergi, Giuseppe; Crepaldi, Gaetano; Maggi, Stefania; Minicucci, N.; Noale, Marianna; Grigoletto, Francesco; Perissinotto, Egle; Carbonin, Pierugo

doi:10.1016/j.jagp.2017.05.018

Cited by 101 publications

(93 citation statements)

References 46 publications

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“…The frailty concept, operationalized according to either the Fried phenotype model or the Rockwood deficit accumulation model, is, in fact, mainly centered on measures of physical performance and presence of functional deficits 5. However, population-based studies have shown that, among community-dwelling older individuals diagnosed with frailty, those carrying signs of mild cognitive impairment (MCI) have poorer outcomes, supporting cognitive frailty as a distinct physiopathologic and clinical syndrome 6,7…”

Section: Introductionmentioning

confidence: 99%

“…The critical issues concern both the evaluation of cognitive symptoms (diagnosis of MCI or clinical dementia rating scale score of 0.5) and of frailty (Fried criteria or a modified version of Cardiovascular Health Study criteria). The criteria used in the Italian Longitudinal Study on Aging7 are reported in Table 1. In this study, MCI was diagnosed using a battery of neuropsychological tests and not the clinical dementia rating scale,7 in line with the most recent consensus recommendations 12.…”

Section: Introductionmentioning

confidence: 99%

“…The criteria used in the Italian Longitudinal Study on Aging7 are reported in Table 1. In this study, MCI was diagnosed using a battery of neuropsychological tests and not the clinical dementia rating scale,7 in line with the most recent consensus recommendations 12. However, in other studies, a Mini-Mental State Examination test score ≤25 was used as a simplified method for assessing cognitive symptoms 13…”

Section: Introductionmentioning

confidence: 99%

“…Cognitive frailty may be reversible, particularly in those patients where cognitive frailty is diagnosed based only on subjective cognitive decline (clinical dementia rating scale score 0.5) in the absence of a certified MCI 7. Early identification of this condition, through measurement of reliable biomarkers, is thus pivotal for secondary prevention of dementia 22,23.…”

Section: Introductionmentioning

confidence: 99%

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Gut microbiota, cognitive frailty and dementia in older individuals: a systematic review

Ticinesi¹,

Tana²,

Nouvenne³

et al. 2018

CIA

168

133

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Cognitive frailty, defined as the coexistence of mild cognitive impairment symptoms and physical frailty phenotype in older persons, is increasingly considered the main geriatric condition predisposing to dementia. Recent studies have demonstrated that gut microbiota may be involved in frailty physiopathology by promoting chronic inflammation and anabolic resistance. The contribution of gut microbiota to the development of cognitive impairment and dementia is less defined, even though the concept of “gut–brain axis” has been well demonstrated for other neuropsychiatric disorders. The aim of this systematic review was to summarize the current state-of-the-art literature on the gut microbiota alterations associated with cognitive frailty, mild cognitive impairment and dementia and elucidate the effects of pre- or probiotic administration on cognitive symptom modulation in animal models of aging and human beings. We identified 47 papers with original data (31 from animal studies and 16 from human studies) suitable for inclusion according to our aims. We concluded that several observational and intervention studies performed in animal models of dementia (mainly Alzheimer’s disease) support the concept of a gut–brain regulation of cognitive symptoms. Modulation of vagal activity and bacterial synthesis of substances active on host neural metabolism, inflammation and amyloid deposition are the main mechanisms involved in this physiopathologic link. Conversely, there is a substantial lack of human data, both from observational and intervention studies, preventing to formulate any clinical recommendation on this topic. Gut microbiota modulation of cognitive function represents, however, a promising area of research for identifying novel preventive and treatment strategies against dementia.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Gut microbiota, cognitive frailty and dementia in older individuals: a systematic review

Ticinesi¹,

Tana²,

Nouvenne³

et al. 2018

CIA

168

133

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“…6 Thus, although the International Academy on Nutrition and Aging/International Association of Gerontology and Geriatrics consensus conference originally defined cognitive frailty as a CDR of 0.5, some studies operationally used MCI instead. They measured frailty using a modified version of CHS (5 domains were same, but the methods were not necessarily the same), and defined cognitive frailty using a diagnosis of MCI instead of CDR = 0.5.…”

Section: Explanationmentioning

confidence: 99%

Chapter 2 Frailty concepts

Arai

Kozaki

Kuzuya

et al. 2020

Geriatrics Gerontology Int

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CQ6: How is cognitive frailty defined and diagnosed?CQ7: How prevalent is cognitive frailty? Statement • Cognitive frailty was operationally defined as: (i) presence of physical frailty and cognitive impairment (Clinical Dementia Rating of 0.5); and (ii) exclusion of concurrent Alzheimer's disease or other types of dementias. • Although there are no generally established diagnostic criteria, the literature suggests that the prevalence ranges from 1% to 5%.

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Sarcopenia and Cognitive Impairment

Chen

2021

Sarcopenia

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Additive Role of a Potentially Reversible Cognitive Frailty Model and Inflammatory State on the Risk of Disability: The Italian Longitudinal Study on Aging

Cited by 101 publications

References 46 publications

Gut microbiota, cognitive frailty and dementia in older individuals: a systematic review

Gut microbiota, cognitive frailty and dementia in older individuals: a systematic review

Chapter 2 Frailty concepts

Sarcopenia and Cognitive Impairment

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