Background: Humanitarian actors have rapidly scaled-up NCD services in crisis-affected low-and-middle income countries, in response to the rising global NCD burden. Using the RE-AIM implementation framework, we evaluated a multidisciplinary, primary-level model of NCD care for Syrian refugees and vulnerable Jordanians in Irbid, Jordan. We examined the Reach, Effectiveness, Adoption and acceptance of the programme; the fidelity, adaptation and costs of Implementation; and its Maintenance over time.Methods: This mixed methods, retrospective evaluation, undertaken in 2017, comprised secondary analysis of pre-existing cross-sectional household survey data; analysis of routine cohort data from January 2015 - December 2017; provider-perspective, descriptive costing analysis of total annual, per-patient and per-consultation costs for 2015-2017; clinical audit; medication adherence survey of 300 patients; and qualitative research. The latter involved thematic analysis of individual interviews with patients, staff and stakeholders and two focus group discussions with patients.Results: The programme reached 5.9% of Syrian adults with NCDs in Irbid governorate. The cohort mean age was 54.7 years; 71% had multi-morbidity and 9.9% self-reported a disability. The programme was highly acceptable to patients, staff and stakeholders. Blood pressure and glycaemic control improved as the programme matured and within six months of patient enrolment (with a drop of 7mmHg and 26.8 mg/dL from baseline, respectively). Total costs increased in parallel with increased service complexity from INT$ 4,206,481 in 2015 to 6,739,438 in 2017. Clinical guidelines were reportedly usable and self-reported medication adherence was high. Individual and organisational challenges to programme implementation and maintenance included the impacts of war and the refugee experience on Syrian refugees’ engagement; inadequate low-cost referral options; and operating in a regulated, middle-income country. Essential programme adaptations included refinement of health education and introduction of: mental health and psychosocial services, essential referral pathways, home visit services and a social worker role.Conclusion: RE-AIM proved a valuable tool in evaluating a complex intervention in a protracted humanitarian crisis setting. This programme provided high quality, reliable, free, holistic NCD care and was highly acceptable to patients, providers and stakeholders. We propose that model simplification, cost reduction and use of technology could improve effectiveness and efficiency without reducing acceptability.