Every country relies on a well-functioning road system. However, we do not have a clear understanding yet of the vulnerability of each of these road networks to different forms of disruption. In this study, we aim to better understand how road networks are affected by different disruptive events, to identify hotspots of road network vulnerabilities, and to better target where and what type of future investments can be made to develop more resilient networks. To do so, we developed a fully open source modelling framework to expose over 200 country road systems across the world to random, local, and targeted disruption schemes. For each country, we assessed the impact of such disruptions on intra-country travel activities and regional accessibility. The results highlight the vulnerability of road systems in mountainous and small-island countries owing to the limited availability of alternative routes. Additionally, we find that, on average, low-income countries experience a collapse of road-system services with much fewer disruptions, relative to high-income countries, due to the lack of redundancy in their systems. While the value of goods and services disrupted may be higher in wealthier countries, the results highlight that from an equity perspective, transport infrastructure investments are more desired in low-income country networks.