Addressing health disparities as a function of ethnicity in systemic lupus erythematosus patients

González, Luis Alonso; Ugarte‐Gil, Manuel F.; Pons-Estel, Guillermo J.; Duran-Barragán, Sergio; Toloza, Sergio; Burgos, Paula I.; Bertoli, Ana M.; Borgia, R. Ezequiel; Alarcón, Graciela S.

doi:10.1177/09612033221122983

Cited by 8 publications

(3 citation statements)

References 99 publications

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“…Racial and ethnic groups are diverse and heterogeneous, and their health conditions are influenced by numerous factors, including geographic location, socioeconomic status, educational attainment, and healthcare access, among others. To fully understand the root causes of health inequities and disparities, it is essential to consider the social and physical environment surrounding a particular population [101,102].…”

Section: Disparities In Gene Functions In Different Races In the Etio...mentioning

confidence: 99%

The Role of Genetic Risk Factors in Pathogenesis of Childhood-Onset Systemic Lupus Erythematosus

Šestan

Kifer

Arsov

et al. 2023

CIMB

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The pathogenesis of childhood-onset systemic lupus erythematosus (cSLE) is complex and not fully understood. It involves three key factors: genetic risk factors, epigenetic mechanisms, and environmental triggers. Genetic factors play a significant role in the development of the disease, particularly in younger individuals. While cSLE has traditionally been considered a polygenic disease, it is now recognized that in rare cases, a single gene mutation can lead to the disease. Although these cases are uncommon, they provide valuable insights into the disease mechanism, enhance our understanding of pathogenesis and immune tolerance, and facilitate the development of targeted treatment strategies. This review aims to provide a comprehensive overview of both monogenic and polygenic SLE, emphasizing the implications of specific genes in disease pathogenesis. By conducting a thorough analysis of the genetic factors involved in SLE, we can improve our understanding of the underlying mechanisms of the disease. Furthermore, this knowledge may contribute to the identification of effective biomarkers and the selection of appropriate therapies for individuals with SLE.

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Section: Disparities In Gene Functions In Different Races In the Etio...mentioning

confidence: 99%

The Role of Genetic Risk Factors in Pathogenesis of Childhood-Onset Systemic Lupus Erythematosus

Šestan

Kifer

Arsov

et al. 2023

CIMB

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“…Systemic lupus erythematosus (SLE) is an incurable, autoimmune disease of unknown aetiology, which severely limits quality of life and economic productivity in patients (Sutanto et al 2013 ; Daly et al 2015 ; Rees et al 2017 ). SLE has a strong female bias (female to male ratio of ≈ 9:1) and is more prevalent and severe in vulnerable and disadvantaged populations than in Caucasians (Ferucci et al 2014 ; Somers et al 2014 ; Plantinga et al 2016 ; González et al 2022 ; Aguirre et al 2023 ). More specifically, SLE tends to exhibit higher disease activity and greater damage accrual in non-Caucasian populations (Hispanics, African descendants and Asians).…”

Section: Introductionmentioning

confidence: 99%

“…The specific factors responsible for the ethnic disparity in SLE and LN are complex and include genetic, cultural and socioeconomic factors (e.g. geographical place of residence: urban vs rural) (González et al 2022 ). Both genetic and non-genetic components influence the expression and outcome of SLE, including disease activity, damage accrual, work disability and mortality.…”

Section: Introductionmentioning

confidence: 99%

Potential of bone morphogenetic protein-7 in treatment of lupus nephritis: addressing the hurdles to implementation

Smith,

du Toit,

Ollewagen

2023

Inflammopharmacol

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Up to 50% of systemic lupus erythematosus (SLE) patients world-wide develop lupus nephritis (LN). In low to middle income countries and in particular in sub-Saharan Africa, where SLE is prevalent with a more aggressive course, LN and end stage renal disease is a major cause of mortality. While developed countries have the funding to invest in SLE and LN research, patients of African descent are often underrepresented in clinical trials. Thus, the complex influence of ethnicity and genetic background on outcome of LN and SLE as a whole, is not fully understood. Several pathophysiological mechanisms including major role players driving LN have been identified. A large body of literature suggest that prevention of fibrosis—which contributes to chronicity of LN—may significantly improve long-term prognosis. Bone morphogenetic protein-7 (BMP-7) was first identified as a therapeutic option in this context decades ago and evidence of its benefit in various conditions, including LN, is ever-increasing. Despite these facts, BMP-7 is not being implemented as therapy in the context of renal disease. With this review, we briefly summarise current understanding of LN pathology and discuss the evidence in support of therapeutic potential of BMP-7 in this context. Lastly, we address the obstacles that need to be overcome, before BMP-7 may become available as LN treatment.

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Contributions of Synthetic Chemicals to Autoimmune Disease Development and Occurrence

Kosarek,

Preston

2024

Curr Envir Health Rpt

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Addressing health disparities as a function of ethnicity in systemic lupus erythematosus patients

Cited by 8 publications

References 99 publications

The Role of Genetic Risk Factors in Pathogenesis of Childhood-Onset Systemic Lupus Erythematosus

The Role of Genetic Risk Factors in Pathogenesis of Childhood-Onset Systemic Lupus Erythematosus

Potential of bone morphogenetic protein-7 in treatment of lupus nephritis: addressing the hurdles to implementation

Contributions of Synthetic Chemicals to Autoimmune Disease Development and Occurrence

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