Addressing scale-up challenges and enhancement in performance of hydrogen-producing microbial electrolysis cell through electrode modifications

Park, Sung Gwan; Rajesh, P. P.; Sim, Young-Uk; Jadhav, Dipak A.; Noori, Md. T.; Kim, Dongho; AlQaradawi, Siham Y.; Yang, Euntae; Jang, Jae-Kyung; Chae, Kyu-Jung

doi:10.1016/j.egyr.2022.01.198

Cited by 78 publications

(20 citation statements)

References 180 publications

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“…Modification to improve the microbe-electrode interaction has been conducted on both MECs and MFCs [ 79 ]. Electrode and microbial modifications, cell immobilisation, and electrode material selection have been extensively researched [ 80 , 81 , 82 ]. Although hydrogels are not commonly used within MEC research, other microbe immobilisation methods are used [ 83 ].…”

Section: Hydrogels Used In Metsmentioning

confidence: 99%

Recent Implementations of Hydrogel-Based Microbial Electrochemical Technologies (METs) in Sensing Applications

Wang

Shi

et al. 2023

Sensors

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Hydrogel materials have been used extensively in microbial electrochemical technology (MET) and sensor development due to their high biocompatibility and low toxicity. With an increasing demand for sensors across different sectors, it is crucial to understand the current state within the sectors of hydrogel METs and sensors. Surprisingly, a systematic review examining the application of hydrogel-based METs to sensor technologies has not yet been conducted. This review aimed to identify the current research progress surrounding the incorporation of hydrogels within METs and sensors development, with a specific focus on microbial fuel cells (MFCs) and microbial electrolysis cells (MECs). The manufacturing process/cost, operational performance, analysis accuracy and stability of typical hydrogel materials in METs and sensors were summarised and analysed. The current challenges facing the technology as well as potential direction for future research were also discussed. This review will substantially promote the understanding of hydrogel materials used in METs and benefit the development of electrochemical biosensors using hydrogel-based METs.

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Section: Hydrogels Used In Metsmentioning

confidence: 99%

Recent Implementations of Hydrogel-Based Microbial Electrochemical Technologies (METs) in Sensing Applications

Wang

Shi

et al. 2023

Sensors

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“…The protons combine with the electrons in the cathode chamber to produce hydrogen gas. However, the production of bio-hydrogen at the cathode is an endothermic reaction and therefore requires an applied voltage (0.2–0.8 V) [ 14 ]. The applied voltage (power supply) for bio-hydrogen production at the MEC (0.2–0.9 V) is much lower than for water electrolysis (1.23–1.8 V).…”

Section: Microbial Electrolysis Cells (Mecs)mentioning

confidence: 99%

Influence of Nanomaterials and Other Factors on Biohydrogen Production Rates in Microbial Electrolysis Cells—A Review

et al. 2022

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Microbial Electrolysis Cells (MECs) are one of the bioreactors that have been used to produce bio-hydrogen by biological methods. The objective of this comprehensive review is to study the effects of MEC configuration (single-chamber and double-chamber), electrode materials (anode and cathode), substrates (sodium acetate, glucose, glycerol, domestic wastewater and industrial wastewater), pH, temperature, applied voltage and nanomaterials at maximum bio-hydrogen production rates (Bio-HPR). The obtained results were summarized based on the use of nanomaterials as electrodes, substrates, pH, temperature, applied voltage, Bio-HPR, columbic efficiency (CE) and cathode bio-hydrogen recovery (C Bio-HR). At the end of this review, future challenges for improving bio-hydrogen production in the MEC are also discussed.

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“…Employing the developmental scale instrument to manufacture commercials will prevent scaleup-related issues and save time and capital for the pharmaceutical industries. In fact, within continuous manufacturing, the quality of products can be continuously monitored and controlled by mounting suitable process analytical technology (PAT) tools [11,12]. Any discrepancies triggered during the continuous run do not require quarantine of the entire batch.…”

Section: Introductionmentioning

confidence: 99%

A review of hot melt extrusion paired fused deposition modeling three-dimensional printing for developing patient centric dosage forms

Dhoppalapudi¹,

Illa²

2022

GSC Biol. Pharm. Sci.

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In recent years, the demand for developing patient-centric dosage forms is increasing enormously with the increasing patient population. Much research is ongoing exploring various additive manufacturing techniques for developing pharmaceutical medications. Poor solubility of drug substances and underdeveloped manufacturing strategies are majorly affecting the pharmaceutical industry's revenue. Developing intravenous dosage forms for drug substances with poor solubility will affect the revenue of the pharmaceutical industries. Thus, improving solubility remains to be the major prerequisite for the developmental scientist. In addition to improving solubility, establishing a robust manufacturing process with commercial viability is also essential. In recent years hot melt extrusion (HME) has been most widely investigated for developing amorphous solid dispersions (ASDs) over other techniques such as spray drying and KinetisolÒ. The process of HME can be coupled with the fused deposition modeling (FDM) three-dimensional (3D) printing technique which is capable of fabricating on-demand patient-centric dosage forms. A continuous manufacturing line can be established by painting HME and FDM 3D printing processes. The quality of the product can be controlled and monitored by employing suitable process analytical technology (PAT) tools. Though the process of the HME-paired FDM 3D printing process has resulted in various advantages compared to the conventional manufacturing process, still many limitations, such as the limited number of polymers, reproducibility, and stability, need to be addressed.

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Addressing scale-up challenges and enhancement in performance of hydrogen-producing microbial electrolysis cell through electrode modifications

Cited by 78 publications

References 180 publications

Recent Implementations of Hydrogel-Based Microbial Electrochemical Technologies (METs) in Sensing Applications

Recent Implementations of Hydrogel-Based Microbial Electrochemical Technologies (METs) in Sensing Applications

Influence of Nanomaterials and Other Factors on Biohydrogen Production Rates in Microbial Electrolysis Cells—A Review

A review of hot melt extrusion paired fused deposition modeling three-dimensional printing for developing patient centric dosage forms

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