Addressing stability issues of vildagliptin: Method optimization and validation for accurate analysis in human plasma
Santosh Tawari,
Ujashkumar Shah
Abstract:This research paper introduces novel strategies to address the stability issues arising with vildagliptin, marking the first attempt to tackle this challenge comprehensively. The study incorporates malic acid into the human plasma, a crucial step in stabilizing vildagliptin and preventing its degradation. Additionally, optimization of the elution process on a C18 Asentis Express column, fine‐tuned with a combination of acetonitrile and ammonium trifluoroacetate 5mM, ensures optimal chromatographic conditions. … Show more
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