Revolving in and out of prisons and jails is no way to recover from a devastating disease like schizophrenia-but that is the challenge facing too many people with serious mental illnesses. In addition to complex health needs that often include substance misuse and medical comorbidities, mentally ill individuals who reenter the community from prison are at risk for unemployment, homelessness, and criminal recidivism. 1 What role does treatment with psychotropic medications have in improving outcomes for this population?In this issue of JAMA, Chang et al 2 report the association between treatment and reduction in violent crime among individuals released from Swedish prisons. This well-designed pharmacoepidemiologic study analyzed data on characteristics, treatment patterns, and criminal offending outcomes in the population of released prisoners in Sweden (N = 22 275) between July 1, 2005, and December 31, 2010, with follow-up through December 31, 2013. Specifically, the authors used proportional hazard statistical models to compare multivariableadjusted probabilities of violent reoffending between individuals prescribed different classes of psychotropic medications or negative control, and within the same individuals during periods when medications were dispensed vs not dispensed.During a median follow-up of 4.6 years, 4031 individuals (18.1%) committed 5653 new violent offenses, which included homicide, assault, robbery, arson, sexual offense, illegal threats, or intimidation. Rates of violent reoffending were significantly lower during periods when antipsychotics, psychostimulants, and drugs for addiction were dispensed, compared with periods in which they were not; risk differences attributable to these 3 respective drug classes were 39.7, 42.8, and 36.4 fewer violent offenses per 1000 person-years, with respective hazard ratios of 0.58 (95% CI, 0.39-0.88), 0.62 (95% CI, 0.40-0.98), and 0.48 (95% CI, 0.23-0.97). No significant associations were found for antidepressants, anticonvulsants, or negative control (adrenergic inhalants, with negligible psychotropic effects). Diagnosis-stratified sensitivity analyses found drug class differences to be specific to diagnostic category, providing additional confidence in causal inference related to drug treatment.Despite its scientific elegance and robust findings, the study by Chang and colleagues invites questions about context. How generalizable is this information regarding the potential crime-inhibiting properties of medications? Previous research has found that the link between mental illness and violent behavior is substantially conditioned by other risk factors such as early-life victimization and exposure to violence