Addressing the challenges of severe asthma

Bellanti, Joseph A.; Settipane, Russell A.

doi:10.2500/aap.2015.36.3874

Cited by 5 publications

(2 citation statements)

References 21 publications

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“…Several asthma phenotypes have been described such as allergic bronchopulmonary mycosis and severe late-onset hypereosinophilic asthma [ 4 , 5 ]; however, a small group of patients have asthma that is uncontrolled or only partially controlled despite intensive treatment [ 6 ]. This form of asthma is commonly referred to as severe asthma [ 7 ] which is often associated with serious morbidity and even mortality [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Exosomes in Severe Asthma: Update in Their Roles and Potential in Therapy

Mortaz

Alipoor

Varahram

et al. 2018

BioMed Research International

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Exosomes are nanosized vesicles and have recently been recognized as important players in cell-to-cell communication. Exosomes contain different mediators such as proteins, nucleic acids (DNA, mRNA, miRNAs, and other ncRNAs), and lipid mediators and can shuttle their exosomal content to both neighboring and distal cells. Exosomes are very effective in orchestrating immune responses in the airways and all cell types can contribute to the systemic exosome pool. Intracellular communication between the broad range of cell types within the lung is crucial in disease emphasizing the importance of exosomes. In asthma, exosomes affect the inflammatory microenvironment which ultimately determines the development or alleviation of the pathological symptoms. Recent studies in this area have provided insight into the underlying mechanisms of disease and led to interest in using exosomes as potential novel therapeutic agents.

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Section: Introductionmentioning

confidence: 99%

Exosomes in Severe Asthma: Update in Their Roles and Potential in Therapy

Mortaz

Alipoor

Varahram

et al. 2018

BioMed Research International

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“…This could happen once the SpO2 stays below 92% in addition to silent chest, poor respiratory, agitation, confusion and cyanosis. [18] referred to some reasons such as patient non-compliance to the prescribed course of medication, incorrect inhaler usage and limited patient awareness about asthma triggers.…”

Section: Asthma and Healthcarementioning

confidence: 99%

A review of air quality sensing technologies and their potential interfaces with IoT for asthma management

Bamashmoos

Woznowski

Tryfonas

2018

Proceedings of the 11th PErvasive Technologies Related to Assistive Environments Conference

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In recent years significant advancement has been achieved on the domain of assessing air quality and monitoring the condition of asthma based on sensing technology. The pervasiveness of relevant devices could have a powerful impact on enabling patients selfmonitoring and increasing public awareness on the air they breathe. In this study, we investigated a variety of different sensors devices relevant to the monitoring of air quality and different devices for assessing the condition of asthma. Our approach at this stage has been based on feature comparison based on product specification sheets and published case studies. We found that there is no standardisation among such devices and that in order for someone to deliver a holistic intervention for the management of a condition like asthma, a significant amount of proprietary effort to integrate third party data and technologies would be required. Such a solution would include both typical air quality sensing and asthma indicators monitoring, but also elements to seamlessly integrate sensed data and logic about the management of the condition.

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