Addressing the Challenges of Tuberculosis: A Brief Historical Account

Al-Humadi, Hussam; Al-Saigh, Rafal; Al-Humadi, Ahmed

doi:10.3389/fphar.2017.00689

Cited by 40 publications

(26 citation statements)

References 111 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A paper published in 1949 mentions that in 1937 CEP, given in tablets or in liquid, contributed to reduce considerably (from 41% to 22%) the average mortality in patients with severe pulmonary tuberculosis at the Yokohama Sanatorium in Japan (Hasegawa, 1949). At that time, the antitubercular activity of CEP was largely promoted, but later the drug was abandoned, superseded by more active products (Al-Humadi et al, 2017). Nevertheless, the initial successful clinical use of CEP for the treatment of tuberculosis has encouraged its use in other pathological indications (e.g., pertussis, leprosy and lupus vulgaris) and associated research activities to elucidate its mode of action.…”

mentioning

confidence: 99%

Cepharanthine: An update of its mode of action, pharmacological properties and medical applications

2019

View full text Add to dashboard Cite

A B S T R A C TBackground: Cepharanthine (CEP) is a drug used in Japan since the 1950s to treat a number of acute and chronic diseases, including treatment of leukopenia, snake bites, xerostomia and alopecia. It is the only approved drug for Human use in the large class of bisbenzylisoquinoline alkaloids. This natural product, mainly isolated from the plant Stephania cephalantha Hayata, exhibits multiple pharmacological properties including anti-oxidative, anti-inflammatory, immuno-regulatory, anti-cancer, anti-viral and anti-parasitic properties. Purpose: The mechanism of action of CEP is multifactorial. The drug exerts membrane effects (modulation of efflux pumps, membrane rigidification) as well as different intracellular and nuclear effects. CEP interferes with several metabolic axes, primarily with the AMP-activated protein kinase (AMPK) and NFκB signaling pathways. In particular, the anti-inflammatory effects of CEP rely on AMPK activation and NFκB inhibition. Conclusion: In this review, the historical discovery and development of CEP are retraced, and the key mediators involved in its mode of action are presented. The past, present, and future of CEP are recapitulated. This review also suggests new opportunities to extend the clinical applications of this well-tolerated old Japanese drug.

show abstract

mentioning

confidence: 99%

Cepharanthine: An update of its mode of action, pharmacological properties and medical applications

2019

View full text Add to dashboard Cite

show abstract

“…La tuberculosis es una enfermedad altamente contagiosa que afecta principalmente a los pulmones y es causada por el patógeno Mycobacterium tuberculosis (Al-Humadi, 2017). Esta enfermedad constituye un problema de salud a nivel mundial; de acuerdo con la Organización Mundial de la Salud (OMS), se han estimado más de 10.4 millones de casos nuevos y 1.8 millones de fallecimientos en el año 2015 (Churchyard 2017).…”

Section: Actividad Antituberculosaunclassified

Avances en la síntesis de Tioureas y su importancia Biológica

Cabrera¹,

Lara²,

Cruz³

et al. 2018

ICBI

View full text Add to dashboard Cite

Las tioureas son compuestos orgánicos cuya síntesis y reactividad ha sido extensamente estudiada en muchos campos de la química, debido a las diversas aplicaciones biológicas y medicinales que estos compuestos poseen. Los métodos más comunes para sintetizar tioureas involucran reactivos como el tiofosgeno, con alto grado de toxicidad, o los isotiocianatos que son difíciles de preparar, pero además se requieren condiciones drásticas de reacción para algunas veces obtener productos con bajos rendimientos. Por lo que cada día se buscan nuevas alternativas en la síntesis de tioureas que permitan obtenerlas de manera rápida, económica y que además se minimice el uso de condiciones drásticas de reacción, catalizadores y disolventes que sean inflamables y contaminen el medio ambiente.

show abstract

“…About 10% of all persons initially infected progress to active disease which is symptomatic and transmissible. However, most people (90%) develop a latent (or dormant) infection, which is asymptomatic and non-transmissible [12]. Latent tuberculosis infection is characterized by the presence of immune responses to TB infection without clinical evidence of active TB [13].…”

Section: Introductionmentioning

confidence: 99%

The War against Tuberculosis: A Review of Natural Compounds and Their Derivatives

et al. 2020

View full text Add to dashboard Cite

Tuberculosis (TB), caused by the bacterial organism Mycobacterium tuberculosis, pose a major threat to public health, especially in middle and low-income countries. Worldwide in 2018, approximately 10 million new cases of TB were reported to the World Health Organization (WHO). There are a limited number of medications available to treat TB; additionally, multi-drug resistant TB and extensively-drug resistant TB strains are becoming more prevalent. As a result of various factors, such as increased costs of developing new medications and adverse side effects from current medications, researchers continue to evaluate natural compounds for additional treatment options. These substances have the potential to target bacterial cell structures and may contribute to successful treatment. For example, a study reported that green and black tea, which contains epigallocatechin gallate (a phenolic antioxidant), may decrease the risk of contracting TB in experimental subjects; cumin (a seed from the parsley plant) has been demonstrated to improve the bioavailability of rifampicin, an important anti-TB medication, and propolis (a natural substance produced by honeybees) has been shown to improve the binding affinity of anti-TB medications to bacterial cell structures. In this article, we review the opportunistic pathogen M. tuberculosis, various potential therapeutic targets, available therapies, and natural compounds that may have anti-TB properties. In conclusion, different natural compounds alone as well as in combination with already approved medication regimens should continue to be investigated as treatment options for TB.

show abstract

Addressing the Challenges of Tuberculosis: A Brief Historical Account

Cited by 40 publications

References 111 publications

Cepharanthine: An update of its mode of action, pharmacological properties and medical applications

Cepharanthine: An update of its mode of action, pharmacological properties and medical applications

Avances en la síntesis de Tioureas y su importancia Biológica

The War against Tuberculosis: A Review of Natural Compounds and Their Derivatives

Contact Info

Product

Resources

About