Addressing the recurrent Nipah Virus outbreaks: A call for vigilance, collaboration, and preparedness

Olatunji, Gbolahan; Kokori, Emmanuel; Abdulrahmon, Moradeyo Akanmu; Aderinto, Nicholas

doi:10.1016/j.nmni.2023.101184

Cited by 2 publications

(3 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Kerala’s health authorities have showcased remarkable proficiency in contact tracing and initiated comprehensive efforts in collaboration with the neighboring states of Karnataka and Tamil Nadu, strengthening their vigilance against potential cases and preventing cross-border transmission. 8…”

Section: Challenges and Ongoing Efforts In South Asiamentioning

confidence: 99%

“…The role of an effective surveillance system was evident in the 2018 outbreak in Kerala, where health authorities conducted thorough contact tracing, quarantined those who were infected, and enhanced hospital infection control measures, effectively managing the outbreak within a month. 8 Thus, it is advised to increase the vigilance and monitoring of the NiV cases to promptly identify and respond to future outbreaks.…”

Section: Imperatives and Action Plans To Combat Public Health Threats...mentioning

confidence: 99%

See 1 more Smart Citation

South Asia’s Strategic Readiness Amidst Worsening Nipah Virus Threats: Current Situation and Imperatives

Singh,

Fatima,

Shaikh

et al. 2024

Asia Pac J Public Health

View full text Add to dashboard Cite

Section: Challenges and Ongoing Efforts In South Asiamentioning

confidence: 99%

Section: Imperatives and Action Plans To Combat Public Health Threats...mentioning

confidence: 99%

South Asia’s Strategic Readiness Amidst Worsening Nipah Virus Threats: Current Situation and Imperatives

Singh,

Fatima,

Shaikh

et al. 2024

Asia Pac J Public Health

View full text Add to dashboard Cite

“…Together, these viruses have been responsible for numerous outbreaks that have led to severe and highly lethal acute respiratory and neurological disease in humans, as well as the infection and subsequent destruction of large numbers of economically important livestock (Bishop and Broder, 2008;Luby et al, 2009;Broder et al, 2016). NiV is particularly concerning, as nearly annual outbreaks have occurred in Bangladesh and India since 2001, human-to-human transmission has been demonstrated, and human cases have a fatality rate, often >75% (Luby, 2013;Olatunji et al, 2023). As a result of their high mortality rate and lack of approved human vaccines or therapeutics, HeV and NiV are classified as Biosafety Level-4 (BSL-4) agents.…”

Section: Introductionmentioning

confidence: 99%

An in vivo BSL-2 model for henipavirus infection based on bioluminescence imaging of recombinant Cedar virus replication in mice

Huaman,

Clouse,

Rader

et al. 2024

Front. Chem. Biol.

View full text Add to dashboard Cite

Henipaviruses are enveloped single-stranded, negative-sense RNA viruses of the paramyxovirus family. Two henipaviruses, Nipah virus and Hendra virus, cause a systemic respiratory and/or neurological disease in humans and ten additional species of mammals, with a high fatality rate. Because of their highly pathogenic nature, Nipah virus and Hendra virus are categorized as BSL-4 pathogens, which limits the number and scope of translational research studies on these important human pathogens. To begin to address this limitation, we are developing a BSL-2 model of authentic henipavirus infection in mice, using the non-pathogenic henipavirus, Cedar virus. Notably, wild-type mice are highly resistant to Hendra virus and Nipah virus infection. However, previous work has shown that mice lacking expression of the type I interferon receptor (IFNAR-KO mice) are susceptible to both viruses. Here, we show that luciferase-expressing recombinant Cedar virus (rCedV-luc) is also able to replicate and establish a transient infection in IFNAR-KO mice, but not in wild-type mice. Using longitudinal bioluminescence imaging (BLI) of luciferase expression, we detected rCedV-luc replication as early as 10 h post-infection. Viral replication peaks between days 1 and 3 post-infection, and declines to levels undetectable by bioluminescence imaging by 7 days post-infection. Immunohistochemistry is consistent with viral infection and replication in endothelial cells and other non-immune cell types within tissue parenchyma. Serology analyses demonstrate significant IgG responses to the Cedar virus surface glycoprotein with potent neutralizing activity in IFNAR-KO mice, whereas antibody responses in wild-type animals were non-significant. Overall, these data suggest that rCedV-luc infection of IFNAR-KO mice represents a viable platform for the study of in vivo henipavirus replication, anti-henipavirus host responses and henipavirus-directed therapeutics.

show abstract

Addressing the recurrent Nipah Virus outbreaks: A call for vigilance, collaboration, and preparedness

Cited by 2 publications

References 3 publications

South Asia’s Strategic Readiness Amidst Worsening Nipah Virus Threats: Current Situation and Imperatives

South Asia’s Strategic Readiness Amidst Worsening Nipah Virus Threats: Current Situation and Imperatives

An in vivo BSL-2 model for henipavirus infection based on bioluminescence imaging of recombinant Cedar virus replication in mice

Contact Info

Product

Resources

About