In depleted offshore reservoirs, pore pressure declines and consequently horizontal in-situ stresses decrease as well. This causes a very limited well depth for extended-reach drilling targeting to offshore depleted reservoirs. In this paper, based on analyzing the safe mud weight window of the depleted offshore reservoirs, a model of predicting the Maximum Allowable Measured Depth (MAMD) for extended-reach drilling targeting to offshore depleted reservoirs is developed. Meanwhile, the numerical method of the model is proposed, and the key affecting factors of the MAMD are also investigated. The results show the pore pressure depletion has obvious effects on the MAMD. With the depletion of pore pressure, the safe mud weight window appears narrower and even disappears, consequently the predicted MAMD becomes shorter. For a normal regime depositional environment in the depleted reservoirs, it may be impossible to drill with conventional drilling method in the nearby directions of the maximum horizontal in-situ stress, while it may be much safer and attain a long MAMD when drilling in the directions near the minimum horizontal in-situ stress. Moreover, the MAMD will decrease with the increase of Poisson's ratio and Biot's parameter, and its response to Poisson's ratio is more obvious. For a specific target depleted reservoir, the extended-reach drilling with a high borehole inclination may have a longer MAMD than that with a low borehole inclination. This paper presents a method for promoting the design of extended-reach drilling targeting to offshore depleted reservoirs.