Adduct formation of ionic and nanoparticular silver with amino acids and glutathione

Blaske, Franziska; Stork, Lisa; Sperling, Michael; Kärst, Uwe

doi:10.1007/s11051-013-1928-3

Cited by 13 publications

(6 citation statements)

References 37 publications

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“…In fact the EPS contains a small but considerable and well documented presence of amino acids and proteins with different metal binding capacity due to the presence of thiol groups (Neu et al, 1999;Verdugo et al, 2004;Navarro et al, 2008;Miao et al, 2009). Silver is known to have a range of affinities towards various amino acids, with thiol and amine containing side chains (Shoeib et al, 2002;Blaske et al, 2013).…”

Section: Xas Analysis and Speciation Of Ag And Znmentioning

confidence: 99%

Fate of zinc and silver engineered nanoparticles in sewerage networks

Brunetti

Donner

Laera³

et al. 2015

Water Research

104

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Engineered zinc oxide (ZnO) and silver (Ag) nanoparticles (NPs) used in consumer products are largely released into the environment through the wastewater stream. Limited information is available regarding the transformations they undergo during their transit through sewerage systems before reaching wastewater treatment plants. To address this knowledge gap, laboratory-scale systems fed with raw wastewater were used to evaluate the transformation of ZnO- and Ag-NPs within sewerage transfer networks. Two experimental systems were established and spiked with either Ag- and ZnO-NPs or with their dissolved salts, and the wastewater influent and effluent samples from both systems were thoroughly characterised. X-ray absorption spectroscopy (XAS) was used to assess the extent of the chemical transformation of both forms of Zn and Ag during transport through the model systems. The results indicated that both ZnO- and Ag-NPs underwent significant transformation during their transport through the sewerage network. Reduced sulphur species represented the most important endpoint for these NPs in the sewer with slight differences in terms of speciation; ZnO converted largely to Zn sulfide, while Ag was also sorbed to cysteine and histidine. Importantly, both ionic Ag and Ag-NPs formed secondary Ag sulfide nanoparticles in the sewerage network as revealed by TEM analysis. Ag-cysteine was also shown to be a major species in biofilms. These results were verified in the field using recently developed nanoparticle in situ deployment devices (nIDDs) which were exposed directly to sewerage network conditions by immersing them into a municipal wastewater network trunk sewer and then retrieving them for XAS analysis.

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Section: Xas Analysis and Speciation Of Ag And Znmentioning

confidence: 99%

Fate of zinc and silver engineered nanoparticles in sewerage networks

Brunetti

Donner

Laera³

et al. 2015

Water Research

104

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“…Several studies have been published that confirm the validity of this technique in establishing thiol-NP interactions. [51,[56][57][58] In a typical experiment, the mixture of metallic salt (HAuCl4 or AgNO3), NaBH4, and CYS (as described above) was stirred under argon in the ultrapure water at room temperature for 90 minutes.…”

Section: Molar Ratio Of Reactants [Metallic Salts]:[nabh4]:[biothiol]mentioning

confidence: 99%

Interaction of Small Biothiols with Silver and Gold Nanoparticles

Pem¹,

Pongrac²,

Ulm³

et al. 2019

Preprint

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Improvement in nanosafety is one of the major tasks for innovation force of nanotechology, which may be accomplished by design and development of biocompatible nanomaterials. Biocompatibility assessment demands investigation of nano-bio interactions that affect behavior and fate of nanoparticles in biological systems. Metallic nanoparticles (NPs) are particularly prone to interact with endogenous biothiols like cysteine and glutathione. This study was designed to evaluate intimate interactions between cysteine and glutathione with biomedically relevant metallic NPs, i.e. silver (AgNPs) and gold (AuNPs). Systematic and comprehensive analysis revealed that preparation of AgNPs and AuNPs in the presence of biothiols lead to stable NPs stabilized with oxidized forms of biothiols. Their biocompatibility was tested by evaluation of cell viability, ROS production, apoptosis induction and DNA damage in murine fibroblast cells (L929), while ecotoxicity was tested using aquatic model organism Daphnia magna. The toxicity of these NPs was considerably lower compared to the ionic metal forms. Comparison with data published on polymer-coated NPs evidenced that surface modification with biothiols made them safer for the environment, but more toxic for use in humans. These results represent significant contribution to the collection of knowledge on the role of biothiols on the fate and behavior of metal-based nanomaterials.

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“…[138][139][140]142 In the cited papers, first of all, DNA-binding ability has been usually investigated, because the anticancer activity is related to the interaction with DNA. [148][149][150][151][152][153][154] For example, chelation of Orn, Ile, Ser or His to nano-sized gold salt, resulted in the formation of a complex with 1 : 1 metal to ligand ratio. 146 In some cases antimicrobial effects have been tested, too.…”

Section: Applicationsmentioning

confidence: 99%

“…[143][144][145]147 In this respect, e.g. 150 Zn(II)-and Al(III)-containing layered double hydroxide (LDH) nanosheets were used to modify chiral aamino acids, including L-Glu, L-Ala, and L-Ser, by intercalating their anions into the interlayer regions of LDHs. 147 Very different goals (for example, researches in nano-biotechnology, chemistry, medical and material sciences) have initiated works on the synthesis of nano-sized compounds with the involvement of amino acids.…”

Section: Applicationsmentioning

confidence: 99%

“…It was found in recent studies that formation of oxytocin dimers is suppressed in the presence of metal ions in aspartate buffer. 310 The gas-phase Co(II), Ni(II), Cu(II) and Zn(II) complexes of glutathione was studied by mass spectrometry and the importance of metal ion reduction was demonstrated. Cu(II) complexes of disulfide-constrained cyclic tetrapeptides were also studied in order to facilitate the design of sensors for metal ions.…”

Section: Metal Complexes Of Peptide Fragments Of Prion Proteinmentioning

confidence: 99%

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