Adecuación de la prescripción de antimicrobianos en población pediátrica en un servicio de urgencias hospitalario

Santander, Borja Croche; Alonso, Elena Campos; Carrión, Adela Sánchez; Fuentes, Laura Marcos; Flores, Isabel Diaz; Vargas, Juan Carlos; Domínguez, Bárbara Fernández; Ibañez, Cristóbal Toro

doi:10.1016/j.anpedi.2017.06.001

Cited by 17 publications

(8 citation statements)

References 29 publications

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“…In all, one in five children attending ED in Lombardy received an antibiotic prescription. This is similar to the rates in other international studies (eg, 16.5% in Spain) 11…”

Section: Discussionsupporting

confidence: 92%

“…Amoxicillin is the most commonly prescribed antibiotic in other countries. Looking at all URTIs, amoxicillin covered from 28% to 85% of antibiotic prescriptions in EDs 11–13 20. In children with AOM, amoxicillin was prescribed for 56% of the cases in the USA and 66% of the cases in France 7 17.…”

Section: Discussionmentioning

confidence: 99%

“…In particular, upper respiratory tract infections (URTIs) are the most common reason for antibiotic prescriptions to children in both outpatient and ED settings 6–8. Antibiotic prescribing patterns to children attending ED do not appear to have been widely evaluated, and studies have mainly focused on a few countries and/or were on respiratory or urinary tract infections 6–21…”

Section: Introductionmentioning

confidence: 99%

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Antibiotic prescription in the outpatient paediatric population attending emergency departments in Lombardy, Italy: a retrospective database review

Messina

Clavenna

Cartabia

et al. 2019

bmjpo

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ObjectivesThis study aimed to assess the appropriateness of antibiotic prescription in children seen in emergency departments (EDs) and to compare prescription profiles in ED and primary care.DesignThis is a retrospective analysis of healthcare administrative databases.SettingThe study analysed data collected in emergency departments (EDs) and primary care practices (PCPs) in Lombardy, Italy.ParticipantsChildren and adolescents between 1 and 13 years old with an ED access and/or an antibiotic prescription in the first semester of 2012 participated in the study. Only those with an index event (ie, without ED access, hospital admissions or antibiotic prescriptions in the previous 60 days) were included.Main outcome measuresThe main outcomes are percentage of subjects receiving amoxicillin (first-choice antibiotic) and percentages receiving macrolides/cephalosporins (second-choice therapies).ResultsDuring the observation period, 133 275 children had one ED access, and 26 087 (19.6%) received an antibiotic prescription. In all, 56.1% of children seen for upper respiratory tract infections (URTIs) received an antibiotic, with a prevalence of 67.8% for otitis media and 56.4% for pharyngotonsillitis; 22.3% of children were given amoxicillin after a visit for URTIs, with no differences among infections, and 19.6% received macrolides and cephalosporins. Few differences were found when comparing the index antibiotic prescriptions in ED and PCP settings. A higher prescription of second-choice antibiotics was observed among children cared for by PCPs compared with children attending EDs (31.3% vs 23.4%, χ2 M-H=720, p<0.001). The place of residence was the main determinant of the qualitative profile of prescriptions.ConclusionsMore must be done to improve rational use of antibiotics in the ED and PCP setting, and educational interventions including physicians in both setting are strongly needed.

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“…In all, one in five children attending ED in Lombardy received an antibiotic prescription. This is similar to the rates in other international studies (eg, 16.5% in Spain) 11…”

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antibiotic prescription in the outpatient paediatric population attending emergency departments in Lombardy, Italy: a retrospective database review

Messina

Clavenna

Cartabia

et al. 2019

bmjpo

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“…Description of antibiotic use errorsThis research observed 36.5% of medical prescriptions containing errors, with a total of 34.5% of antibiotics being improper prescribed.Iftikhar et al, and Denny et al, observed convergent rates of 40.8% and 22.9% improper prescriptions, respectively (47,48). A survey by Santander et al found a convergent rate of 51.9 % of improper medical prescriptions, Okello et al, (68.4%)(49,50). In this research, 57.1%, 27.7%, 11.6% and 3.6% of the prescriptions presented a, two, three and four errors respectively.…”

supporting

confidence: 46%

Inappropriate Use of Antibiotics and Their Predictors in Pediatric Patients Admitted at the Hospital Central De Nampula, Mozambique

Xavier¹,

Victor²,

Cumaquela³

et al. 2021

Preprint

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Background Antibiotics are synthetic or natural substances used to treat diseases of infectious origin. When used incorrectly, they can be a factor in the development of antimicrobial resistance, increased treatment time, costs, and mortality. The present study aimed to assess the pattern inappropriate use of antibiotics and their predictors in pediatric patients admitted to the Hospital Central de Nampula, Mozambique Methods A cross-sectional, retrospective study with a quantitative approach was conducted between January and July 2019. The population consisted of children aged 0 to 10 years hospitalized in the pediatric ward I. Binary logistic regression was used to determine risk factors for inappropriate use of antibiotics with 95% CI. Results The prevalence of antibiotic use among pediatric patients was 97.5%. Of the 464 antibiotics prescribed, 39.9% were for patients suffering from gastroenteritis, 21.8% and 9.1% Affected with pneumonia and malaria. Most antibiotics were for systemic use (95.9%, 445/464). Most (36.5%) of prescriptions had errors. Duration of treatment (74.6%) and dosage (25.4%) were the most frequent errors. Binary logistic regression analysis revealed that patients were prescribed with ≥ 3 antibiotics (OR = 2.920, 95% CI = 1.283–6.646, p–value = 0.011) and with a short hospitalization time (OR = 1.726, 95% CI = 1.040–2.864, p–value = 0.035) were more likely to experience some inappropriate use of antibiotics. Conclusion The study showed a higher prevalence of antibiotic use, however, a greater number of prescriptions contained errors. Errors related to dose and duration of treatment were the most common among pediatric patients. These results reveal a concern, since inappropriate and excessive use of antibiotics is a major factor for the development of antibiotic resistant microorganisms. Therefore, strategies concerning the use of antibiotics in order to reduce their inappropriate and excessive use are necessary.

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“…[385] centros hospitalarios, la literatura muestra que hay deficiencias en el manejo de los antibióticos y en el conocimiento en la administración de los mismos, Santander et al (37) , por ejemplo muestran que existe un desconocimiento en el manejo de los antimicrobianos en España evidenciando que en el 51,9% de casos, se realizaron tratamientos inadecuados, en otro 40,7% el tratamiento fue innecesario, y en un 35,2% la elección del antimicrobiano fue incorrecta, esto demostrando el desconocimiento en el uso de antibióticos. En el presente estudio logramos evidenciar un problema similar al observar que muchos informes de antibióticos no deberían realizarse.…”

Section: Discussionunclassified

Análisis del uso de antibióticos en antibiogramas de urocultivos realizados por un laboratorio clínico de la región centro-occidental de Colombia

2017

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Análisis del uso de antibióticos en antibiogramas de urocultivos realizados por un laboratorio clínico de la región centro-occidental de ColombiaAnalysis of the use of antibiotics in antibiograms of urine carried out by a clinical laboratory of the central-western region of ColombiaCarlos Rodríguez-Salazar 1,2* orcid.org/0000-0002-0071-1289Delia Recalde-Reyes 1,2 orcid.org/0000-0002-7752-1221Leonardo Padilla-Sanabria 1,2 orcid.org/0000-0001-5811-2791 Rodríguez-Salazar C, et al. Univ. Salud. 19(3):378-387, 2017 (Sep -Dic) [379]aeruginosa showed greater resistance and the antibiotic with the highest resistance was nalidixic acid (66.7%). Conclusion:The study showed that there is a problem in managing, reporting and interpreting antibiograms against naturally resistant microorganisms, which could favor the development of multidrug in sensitive microorganisms of bacterial flora. A review of national and international bibliography showed similar reports; however, no author mentions intrinsic resistances, so the data of antibiotic resistance would be over evaluated.

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Adecuación de la prescripción de antimicrobianos en población pediátrica en un servicio de urgencias hospitalario

Cited by 17 publications

References 29 publications

Antibiotic prescription in the outpatient paediatric population attending emergency departments in Lombardy, Italy: a retrospective database review

Antibiotic prescription in the outpatient paediatric population attending emergency departments in Lombardy, Italy: a retrospective database review

Inappropriate Use of Antibiotics and Their Predictors in Pediatric Patients Admitted at the Hospital Central De Nampula, Mozambique

Análisis del uso de antibióticos en antibiogramas de urocultivos realizados por un laboratorio clínico de la región centro-occidental de Colombia

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