Adenine arabinoside therapy in HBsAg-positive chronic liver disease: A controlled study

Psychosocial impact of chronic infection with hepatitis B virus on British patients.

“…There have been recent reports of successful antiviral treatment, elimination of infectivity, and biochemical and histological resolution of liver disease. [25][26][27][28][29] In one study 50% of the patients who were treated with interferon had long term responses.30 It is thus possible to treat patients infected with HBV and enable some of them to return to a normal life.…”

Cellular and virological mechanisms of HBV drug resistance

“…Attempts in the early 1980 s to block HBV replication using inhibitors of viral DNA synthesis were generally unsuccessful because of the poor efficacy and/or toxicity of available drugs, for example, as found with adenosine arabinoside [8][9][10][11][12][13][14][15]. Moreover, with the lack at that time of tissue culture and in vitro systems for virus growth or viral polymerase expression, which were suitable for high throughput screening, antiviral compound libraries could not be tested against HBV.…”

Hepatitis B virus infection in medical and health care personnel.

“…26 Only the prophylactic use of hepatitis B virus vaccines at the start of clinical training is likely to reduce the risk of acquiring hepatitis B virus infection. In a controlled trial among medical and nursing staff in French renal units27 hepatitis B virus vaccination was shown to confer protection against infection, and these encouraging results indicate that immunisation with hepatitis B virus vaccines should be of value in other health care workers with a lower risk of infection.…”