Mobile DNA III 2015
DOI: 10.1128/9781555819217.ch37
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Adeno-associated Virus as a Mammalian DNA Vector

Abstract: In the nearly five decades since its accidental discovery, adeno-associated virus (AAV) has emerged as a highly versatile vector system for both research and clinical applications. A broad range of natural serotypes, as well as an increasing number of capsid variants, has combined to produce a repertoire of vectors with different tissue tropisms, immunogenic profiles and transduction efficiencies. The story of AAV is one of continued progress and surprising discoveries in a viral system that, at first glance, … Show more

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Cited by 26 publications
(31 citation statements)
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References 239 publications
(309 reference statements)
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“…Es gibt verschiedene Kapside, auch Serotypen genannt. Zurzeit werden verschiedene Serotypen auf die Erkennung unterschiedlicher zellulärer Oberflächenrezeptoren, und demzufolge unterschiedliche Zellen, getestet [11,12].…”
Section: Degenerative Erkrankungen Der Retinaunclassified
“…Es gibt verschiedene Kapside, auch Serotypen genannt. Zurzeit werden verschiedene Serotypen auf die Erkennung unterschiedlicher zellulärer Oberflächenrezeptoren, und demzufolge unterschiedliche Zellen, getestet [11,12].…”
Section: Degenerative Erkrankungen Der Retinaunclassified
“…Viruses of this genus are non-enveloped and transduce dividing and non-dividing cells. A complete review of AAV biology is beyond the scope of this article but has been reviewed thoroughly elsewhere [8]. After transduction, the 4.7 kb viral genome remains predominantly episomal, providing long-term gene expression in non-dividing cells.…”
Section: Adeno-associated Viral (Aav) Vectorsmentioning
confidence: 99%
“…Adeno-associated viral (AAV) vectors are amongst the most popular viral vectors for gene therapy applications in pre-clinical and clinical research (1).…”
Section: Introductionmentioning
confidence: 99%