Adenocarcinoma Arising in an Elderly Patient’s Large Ileal Duplication

Tullio, Damiano De; Rinaldi, Rosa; Pellegrini, Davide; Stano, Rocco; Messina, Federico; Cavazzini, Luigi; Azzena, Gianfranco; Occhionorelli, Savino

doi:10.1177/1066896908319443

Cited by 8 publications

(7 citation statements)

References 16 publications

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“…Various malignancies have been reported in enteric duplications, including adenocarcinoma, metastatic adenocarcinoma, carcinoid tumour and squamous cell carcinoma [1,3,[5][6][7][8][9][10]. To our knowledge, only two cases of papillary adenocarcinomas in alimentary tract duplications have been reported, and these were found only in duplication cysts, not in tubular duplications [2,4].…”

Section: Discussionmentioning

confidence: 77%

“…Acute haemorrhage can be encountered in the case of a duplication cyst with gastric mucosa and ulceration. In addition, although rare, malignant change can occur within the intestinal duplication [1][2][3][4][5][6][7][8][9][10]. Papillary adenocarcinoma arising in an intestinal duplication is extremely rare and, to our knowledge, only two cases have been reported in the duplication cysts of the caecum and small bowel [2,4].…”

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confidence: 88%

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Papillary adenocarcinoma arising in a tubular duplication of the jejunum

Kim

Kim²,

Jang³

et al. 2010

BJR

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ABSTRACT. Alimentary tract duplications are uncommon congenital anomalies containing a normal gastrointestinal mucosa and smooth muscle layer. Intestinal duplication in the jejunum is rare, and any malignancy arising in the jejunal duplication is extremely rare. In this report, we present the first case of papillary adenocarcinoma arising in a tubular duplication of the jejunum. Coronal reformatted images from contrast-enhanced CT revealed a well-enhanced tubular mass in the distal jejunum with small bowel obstruction. There were multiple enlarged lymph nodes in the small bowel mesentery around the superior mesenteric artery. The typical macroscopic and histological findings were present.

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Section: Discussionmentioning

confidence: 77%

mentioning

confidence: 88%

Papillary adenocarcinoma arising in a tubular duplication of the jejunum

Kim

Kim²,

Jang³

et al. 2010

BJR

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“…In the small bowel, the majority are adenocarcinomas. [4][5][6][7][8] Carcinoid tumors 9 and squamous cell carcinoma 10 have also been reported. Like small bowel duplications in general, it is common for an associated adenocarcinoma to contain heterotopic mucosa.…”

Section: Commentmentioning

confidence: 99%

Gastroesophageal Heterotopia and HER2/neu Overexpression in an Adenocarcinoma Arising From a Small Bowel Duplication

Nussbaum

Bhattacharya

Jiang

et al. 2014

Archives of Pathology &Amp; Laboratory Medicine

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Small bowel duplications are congenital structures commonly lined by heterotopic gastric or pancreatic mucosa. Though benign in children, small bowel duplications have the potential for malignant degeneration in adulthood. Here, we present the first reported case of metastatic adenocarcinoma arising from a small bowel duplication lined by gastroesophageal mucosa. The cancer demonstrated overexpression of the HER2/neu oncoprotein and amplification of the HER2/neu gene. This represents the only report of HER2 overexpression in this type of lesion. The patient is being treated with traditional chemotherapeutic agents in addition to monoclonal antibody therapy directed at the HER2 protein, and has demonstrated a clinical benefit from treatment. This case demonstrates that the anatomic location of a mass may be distinct from its biological origin, and this difference may have important practical implications for diagnostic testing and treatment.

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“…DC can be communicating or a non-communicating, cystic or tubular structure, lined by a mucosal membrane. Intestinal duplications may remain asymptomatic throughout life or could manifest clinically, depending on their size, specific relation to the bowel segment, or in case of communication with the intestinal lumen [ 2 ]. Malignancies are rare complications in intestinal duplications and are reported with DC of small bowel, colon, and rectum [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Adenocarcinoma of Jejunal Duplication Cyst—Case Report and Review of Literature

Viswanath

Medappil

Rajan

et al. 2021

Indian J Surg Oncol

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Alimentary tract duplication cyst refers to congenital malformations that involve the mesenteric side of bowel and share a common wall or blood supply with the bowel. Duplication cyst occurs in any segment of the gastrointestinal tract from mouth to anus, but is more commonly seen in the mesentery of the ileo-colic region. Duplication cyst presents more frequently in children with abdominal pain or swelling. In adults, the diagnosis of duplication cyst is incidental and can present with complications like bleed, fistula formation, inflammatory mass, and rarely malignant transformation. English-language literature review has shown only three cases of malignancies reported so far associated with jejunal duplication cyst. A case of incidentally detected metastatic adenocarcinoma in a jejunal duplication cyst is being reported here, along with literature review of malignancies associated with small bowel duplication cyst.

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Adenocarcinoma Arising in an Elderly Patient’s Large Ileal Duplication

Cited by 8 publications

References 16 publications

Papillary adenocarcinoma arising in a tubular duplication of the jejunum

Papillary adenocarcinoma arising in a tubular duplication of the jejunum

Gastroesophageal Heterotopia and HER2/neu Overexpression in an Adenocarcinoma Arising From a Small Bowel Duplication

Adenocarcinoma of Jejunal Duplication Cyst—Case Report and Review of Literature

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