Adenocarcinoma Arising in Gastric Heterotopic Pancreas. Case Report and Review of the Literature

Lemaire, Juliette; Delaunoit, Thierry; Molle, G.

doi:10.1080/00015458.2014.11680983

Cited by 17 publications

(12 citation statements)

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“…The management strategy of pancreatic rest should be guided by symptomatology and suspicion of malignancy. While asymptomatic lesions can be followed up, even though some authors recommend resection [13] , symptomatic or malignant lesions should be resected [14] …”

Section: Discussionmentioning

confidence: 99%

A rare case of adenocarcinoma of an ectopic pancreas: A case report

Manhal

Molle

Delaunoit

et al. 2022

International Journal of Surgery Case Reports

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Section: Discussionmentioning

confidence: 99%

A rare case of adenocarcinoma of an ectopic pancreas: A case report

Manhal

Molle

Delaunoit

et al. 2022

International Journal of Surgery Case Reports

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“…Preoperative diagnosis of ectopic pancreas malignancy may be difficult with imaging studies. The prognosis of adenocarcinoma arising from ectopic pancreas is not clear [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ]. However, the prognosis may be better than that of primary pancreatic carcinoma, probably due to the earlier clinical presentation of the carcinoma in ectopic pancreas [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Vesicoenteric Fistula Arising from an Adenocarcinoma of Ectopic Pancreatic Tissue in a Meckel Diverticulum

et al. 2018

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We report a case of a vesicoenteric fistula arising from an adenocarcinoma of ectopic pancreatic tissue in a Meckel diverticulum in a 58-year-old man. The patient suffered from refractory micturition pain and increased urinary frequency. Computerized tomography with a contrast agent showed a ring-shaped enhanced mass near the dome of the urinary bladder. Magnetic resonance imaging showed a cystic mass close to the urinary bladder with partly irregular wall and fistula formation to the urinary bladder. Surgical findings showed a Meckel diverticulum in the ileum, which formed a fistula with the urinary bladder, and Meckel diverticulectomy and partial cystectomy were performed. Histological findings revealed a vesicoenteric fistula arising from a papillary adenocarcinoma of ectopic pancreatic tissue in a Meckel diverticulum. The patient has survived without recurrence for more than 4 years since surgery.

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“…Heterotopic foci of pancreatic tissue may develop invasive ductal adenocarcinoma or its precursor lesions, histologically identical to those in the pancreas [20–22]. These foci provide an opportunity to study the development of these lesions in pancreatic tissue away from the confines and the microenvironment of the pancreas.…”

Section: Discussionmentioning

confidence: 99%

Mutational spectrum of intraepithelial neoplasia in pancreatic heterotopia

Gocke

Hruban

et al. 2016

Human Pathology

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Heterotopic pancreatic parenchyma recapitulates the normal pancreas in extra-pancreatic locations and on rare occasions can even give rise to pancreatic adenocarcinoma. The genetic signatures of pancreatic adenocarcinoma and its precursor lesions are well characterized. We explored the genetic alterations in precursor lesions (intraductal papillary mucinous neoplasms [IPMN], pancreatic intraepithelial neoplasia [PanIN]) in patients with pancreatic heterotopias but without concomitant pancreatic ductal adenocarcinomas. This allowed us to determine whether the stereotypical dysplasia—infiltrating carcinoma sequence also occurs in these extra-pancreatic foci. Seven cases of heterotopic pancreas with ductal precursor lesions were identified. These included two IPMNs with focal high grade dysplasia and five PanINs with low to moderate grade dysplasia (PanIN grades 1–2). Neoplastic epithelium was micro-dissected and genomic DNA was extracted. Sequencing of commonly mutated hotspots (KRAS, TP53, CDKN2A, SMAD4, BRAF, and GNAS) in pancreatic ductal adenocarcinoma and its precursor lesions was performed. Both IPMNs were found to have KRAS codon 12 mutations. The identification of KRAS mutations suggests a genetic pathway shared with IPMN of the pancreas. No mutations were identified in our heterotopic PanINs. One of the possible mechanisms for the development of dysplasia in these lesions is field effect. At the time of these resections there was no clinical or pathologic evidence of a prior or concomitant pancreatic lesion. However, a clinically undetectable lesion is theoretically possible. Therefore, while a field effect cannot be excluded, there was no evidence for it in this study.

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Adenocarcinoma Arising in Gastric Heterotopic Pancreas. Case Report and Review of the Literature

Cited by 17 publications

References 0 publications

A rare case of adenocarcinoma of an ectopic pancreas: A case report

A rare case of adenocarcinoma of an ectopic pancreas: A case report

Vesicoenteric Fistula Arising from an Adenocarcinoma of Ectopic Pancreatic Tissue in a Meckel Diverticulum

Mutational spectrum of intraepithelial neoplasia in pancreatic heterotopia

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