Adenocarcinoma in a Müllerian Duct Cyst

Gilbert, Ronald F.; Ibarra, Julio A.; Tansey, Larry A.; Shanberg, Allan M.

doi:10.1016/s0022-5347(17)36880-5

Cited by 29 publications

(18 citation statements)

References 18 publications

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“…MD cysts are relatively uncommon [1][2][3][9][10][11][12][13]. In the male embryo, regression of the Mu¨llerian duct is completed by Mu¨llerian inhibiting substances produced in the early fetal stage [14].…”

Section: Discussionmentioning

confidence: 99%

“…These cysts can cause hematospermia and other ejaculatory disturbances, testicular or pelviperineal pain, urinary irritations, urinary obstruction, lower urinary tract infection, male infertility, and malignancy [1][2][3][4][5][6][7][8][9][10][11][12][13].…”

Section: Discussionmentioning

confidence: 99%

“…Schema shows the cyst of ejaculatory system in case 1. UB urinary bladder, C cyst, VD vas deferens, V verumontanum patients with such cysts, although tumor formation in a MD cyst has been reported, including adenocarcinoma and squamous-cell carcinoma [10,11]. In patients with ED or MD cysts, obstruction of the ejaculatory duct, abnormal opening of the vas deferens, attachment of the seminal vesicle, or cyst infection may result in infertility [12,15].…”

Section: Discussionmentioning

confidence: 99%

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Cysts of the ejaculatory system: a report of two cases

et al. 2005

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We report two cases of rare cystic dilatations of the ejaculatory system. In case 1, a 6-month-old boy was referred to us for the management of recurrent epididymo-orchitis (E-O) complicating open drainage and a colostomy was performed elsewhere for a purulent rectal discharge thought to be rectal duplication. Diagnostic imaging showed a retrovesical cyst. Urethrocystoscopy showed a swelling of the verumontanum. No fistula was seen between the cyst and rectum on colonoscopy. At laparotomy, both ejaculatory ducts and seminal vesicles were found to be fused into a mass with cystic dilatation of the ejaculatory duct. Intraoperative histopathology of the cyst identified a metaplastic epithelial lesion. The cyst was excised with bilateral vasoligation. Since surgery, 8 years ago, urination and defecation have been normal. In case 2, a 4-month-old boy presented with fever and a swollen right scrotum. Ultrasonography showed a retrovesical cyst. Right grade IV vesicoureteral reflux diagnosed on voiding cystourethrography was treated by ureter reimplantation (Cohen) but complicated by recurrent E-O. Urethrocystoscopy with retrograde contrast via the utriculus showed that the cyst opened on the verumontanum, that both ejaculatory ducts opened into the cyst, and there was reflux into the right vas deferens. Right vasoligation alone was performed through a scrotal approach. Although the cyst was not excised, there has been no recurrence of E-O nor enlargement of the cyst for 6 years. Cysts of the ejaculatory system should be considered in the etiology of recurrent E-O in prepubertal children and a high index of awareness is recommended.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Cysts of the ejaculatory system: a report of two cases

et al. 2005

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“…In addition, all three cases of bladder adenocarcinoma were immunostained for PSA at the time of initial diagnosis, and all were found to be negative. The single case of adenocarcinoma arising in a mullerian duct cyst was previously reported to be negative for PSA and PAP (8).…”

Section: Ca-125 Immunoreactivity In Prostatic Adenocarcinoma Bladdermentioning

confidence: 99%

Primary Seminal Vesicle Carcinoma: An Immunohistochemical Analysis of Four Cases

et al. 2000

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Primary adenocarcinoma of the seminal vesicles is an extremely rare neoplasm. Because prompt diagnosis and treatment are associated with improved long-term survival, accurate recognition of this neoplasm is important, particularly when evaluating limited biopsy material. Immunohistochemistry can be used to rule out neoplasms that commonly invade the seminal vesicles, such as prostatic adenocarcinoma. Previous reports have shown that seminal vesicle adenocarcinoma (SVCA) is negative for prostate-specific antigen (PSA) and prostatespecific acid phosphatase (PAP); however, little else is known of its immunophenotype. Consequently, we evaluated the utility of cancer antigen 125 (CA-125) and cytokeratin (CK) subsets 7 and 20 for distinguishing SVCA from other neoplasms that enter the differential diagnosis.Four cases of SVCA-three cases of bladder adenocarcinoma and a rare case of adenocarcinoma arising in a mullerian duct cyst-were immunostained for CA-125, CK7, and CK20. Three of four cases of SVCA were CA-125 positive and CK7 positive. All four cases were CK20 negative. All bladder adenocarcinomas and the mullerian duct cyst adenocarcinoma were CK7 positive and negative for CA-125 and CK20. In addition, CA-125 immunostaining was performed in neoplasms that commonly invade the seminal vesicles, including prostatic adenocarcinoma (n ‫؍‬ 40), bladder transitional cell carcinoma (n ‫؍‬ 32), and rectal adenocarcinoma (n ‫؍‬ 10), and all were negative for this antigen.In conclusion, the present study has shown that the CK7-positive, CK20-negative, CA-125-positive, PSA/PAP-negative immunophenotype of papillary SVCA is unique and can be used in conjunction with histomorphology to distinguish it from other tumors that enter the differential diagnosis, including

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“…In aktuellen Studien wurden keine histologischen Unterschiede zwischen beiden Entitäten gefunden, so dass der Terminus "Utrikuluszyste" für median gelegene Prostatazysten vorschlagen wurde [7]. Obwohl es sich generell um benigne Fehlbildungen handelt, wurden in der Literatur Einzelfälle von Zystadenokarzinomen beschrieben [4].…”

Section: Prostatic Cyst · 3 T Mr · Dysuria · Müllerian Duct Cyst · Utunclassified

3-T-Prostata-MRT bei symptomatischer Utrikuluszyste

Quentin

Barski

Blondin

2010

Urologe

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Cystic lesions of the prostate are rare and often asymptomatic. Medial cysts are conventionally divided into so-called Müllerian duct cysts and prostatic utricle cysts which seems rather questionable in light of recent studies. We report a case of a patient with a 10-year history of dysuria. Diagnostic imaging was performed using 3 T prostate MRI with a body coil. Because of the potential risk of retrograde ejaculation with subsequent infertility and of incontinence by the transurethral resection, the interventional therapy of his utricle cyst was abandoned.

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Adenocarcinoma in a Müllerian Duct Cyst

Abstract: A case of adenocarcinoma involving a müllerian duct cyst is presented. The presentation, treatment, and pathological and radiological appearance are discussed. The embryology and history of this entity are reviewed.

Cited by 29 publications

References 18 publications

Cysts of the ejaculatory system: a report of two cases

Cysts of the ejaculatory system: a report of two cases

Primary Seminal Vesicle Carcinoma: An Immunohistochemical Analysis of Four Cases

3-T-Prostata-MRT bei symptomatischer Utrikuluszyste

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