Adenocarcinoma in Biliary Papillomatosis

Percutaneous transhepatic biliary endoscopic procedures

“…Following tract dilation to 16 Fr, large amounts of tumor and debris were removed from the common and left main ducts using a combination of baskets and aspiration through large-bore catheters. The pathologist's report was consistent with an "atypical villoglandular polyp of uncertain biological potential" [3,4].…”

Expression of MUC1 and MUC2 and carbohydrate antigen Tn change during malignant transformation of biliary papillomatosis

“…Tumours are composed of delicate papillae covered by tall columnar cells with basal nuclei showing minimal pleomorphism 24 . Although there have been several case reports of biliary papillomatosis showing progression to invasive adenocarcinoma 25 , 26 and point mutation of the K‐ ras gene, 27 the neoplastic potential and biological behaviour have not been studied in detail. There have been several reports on the expression of MUC and carbohydrate antigens (T, Tn and STn) in normal bile duct and its malignant derivatives 28–31 .…”

Papillary adenoma of the distal common bile duct

“…A close association between biliary papilloma or papillary adenomatosis and carcinoma is well documented. [19][20][21][22][23][24][25][26] The tumor in the present patient was composed of a lobulated overgrowth of glandular epithelium with focal severe atypia. There was no invasive growth microscopically, but positive immunoreactivity for MIB-1 and p53 suggested the malignant potential of the lesion.…”