Adenocarcinoma in Meckel's Diverticulum: Case Report and Literature Review

Yamaguchi, Kotaro; Maeda, Shoji; Kitamura, K

doi:10.1111/j.1445-2197.1989.tb07014.x

Cited by 16 publications

(4 citation statements)

References 6 publications

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“…Gastrointestinal stromal tumors (53), leiomyosarcomas (54), and adenocarcinomas (55,56) have also been reported to occur in Meckel diverticula. The imaging features of these tumors are relatively nonspecific and depend on tumor size.…”

Section: Neoplasmsmentioning

confidence: 98%

From the Archives of the AFIP

Levy¹,

Hobbs²

2004

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Meckel diverticulum is the most common congenital anomaly of the gastrointestinal tract, occurring in 2%-3% of the population. It results from improper closure and absorption of the omphalomesenteric duct. Meckel diverticulum is the most common end result of the spectrum of omphalomesenteric duct anomalies, which also include umbilicoileal fistula, umbilical sinus, umbilical cyst, and a fibrous cord connecting the ileum to the umbilicus. The formation of Meckel diverticulum occurs with equal frequency in both sexes, but symptoms from complications are more common in male patients. Sixty percent of patients come to medical attention before 10 years of age, with the remainder of cases manifesting in adolescence and adulthood. Heterotopic gastric and pancreatic mucosa are frequently found histologically within the diverticula of symptomatic patients. The most common complications are hemorrhage from peptic ulceration, small intestinal obstruction, and diverticulitis. Although the clinical, pathologic, and radiologic features of the complications of Meckel diverticulum are well known, the diagnosis of Meckel diverticulum is difficult to establish preoperatively.

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Section: Neoplasmsmentioning

confidence: 98%

From the Archives of the AFIP

Levy¹,

Hobbs²

2004

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245

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“…Other reported tumors include leiomyoma (Fig. 13), leiomyosarcoma [17], angioma, neuroma, lipoma, carcinosarcoma, and adenocarcinoma [18,19]. These tumors have nonspecific imaging features, including a sessile or lobulated filling defect.…”

Section: Neoplasmmentioning

confidence: 99%

Imaging Manifestations of Meckel's Diverticulum

Elsayes

Menias

Harvin

et al. 2007

American Journal of Roentgenology

249

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“…Carcinoid is the most common malignant neoplasm developed in MD, accounting for 33–44% of MD cases, followed by leiomyosarcoma at 18–25%, adenocarcinoma at 12–16%, and gastrointestinal stromal tumor (GIST) at 12% [ 3 ]. Although the clinical symptoms and signs of adenocarcinoma in MD are various, such as gastrointestinal bleeding [ 11 ], elevation of serum CEA and/or CA19-9 levels [ 12 , 13 ], and spontaneous rupture [ 14 ], we have found no published report of adenocarcinoma in an inverted MD with intussusception. MDs often contains heterotopic tissue such as pancreatic tissue or gastric, duodenal, jejunal, and/or colonic mucosa, which are involved in the carcinogenesis [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

An adenocarcinoma in an inverted Meckel’s diverticulum with intussusception

Miwa¹,

Sato²,

Hirano³

et al. 2023

surg case rep

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Background Adenocarcinoma in an inverted Meckel's diverticulum with intussusception has not been reported to date. We discuss the clinical issues concerning this rare condition and review the relevant literature. Case presentation A 71-year-old Japanese female was referred to our hospital for further investigation of severe anemia. Computed tomography revealed a tumorous lesion in the terminal ileum. Capsule endoscopy did not provide detailed images. Exploratory laparoscopy revealed intussusception in the terminal ileum. An intraluminal tumor 70 cm proximal to the ileocecal valve was observed to be the lead point. Partial resection including the tumor was performed. Macroscopically, a polypoid tumor at the tip of an inverted diverticulum-like structure was observed. The tumor was histologically composed of adenocarcinoma accompanied by gastric and pyloric gland metaplasia in the background mucosa, which was confirmed by immunohistochemical staining. Based on these characteristics, this tumor is considered to have developed from the ectopic gastric mucosa in a Meckel's diverticulum. Conclusions When we encounter patients with unfamiliar lesions in the small bowel, we need to differentiate Meckel's diverticulum related disease. Meckel's diverticulum can invert into the lumen of the small bowel and cause an intussusception, and has potential of malignant transformation.

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Adenocarcinoma in Meckel's Diverticulum: Case Report and Literature Review

Cited by 16 publications

References 6 publications

From the Archives of the AFIP

From the Archives of the AFIP

Imaging Manifestations of Meckel's Diverticulum

An adenocarcinoma in an inverted Meckel’s diverticulum with intussusception

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