Adenocarcinoma in pure ground glass nodules: histological evidence of invasion and open debate on optimal management

Morphologic characteristics of pulmonary adenocarcinomas manifesting as pure ground-glass nodules on CT

“…In their editorial, Milanese et al summarize previously reported morphological parameters for risk stratification of pure GGNs, beyond those reported in our own study (2). Those parameters include qualitative parameters, such as air bronchograms and normality of an adjacent vessel, and…”

“…They discuss the applicability of those parameters and their current limitations with respect to clinical practice (2). Both, Milanese et al and Cohen et al confirm our opinion that in the assessment of pure GGNs on a single CT scan, two dimensional CT size, as recommended by current guidelines (6)(7)(8), may be sufficient for clinical risk estimation (1,2). They also confirm that more sophisticated parameters such as volume, density, and roundness may play a lesser role (1,2).…”

“…Letter to the Editor Morphologic characteristics of pulmonary adenocarcinomas manifesting as pure ground-glass nodules on CT quantitative parameters, such entropy and mass (2). They discuss the applicability of those parameters and their current limitations with respect to clinical practice (2).…”

“…Letter to the Editor Morphologic characteristics of pulmonary adenocarcinomas manifesting as pure ground-glass nodules on CT quantitative parameters, such entropy and mass (2). They discuss the applicability of those parameters and their current limitations with respect to clinical practice (2). Both, Milanese et al and Cohen et al confirm our opinion that in the assessment of pure GGNs on a single CT scan, two dimensional CT size, as recommended by current guidelines (6)(7)(8), may be sufficient for clinical risk estimation (1,2).…”

“…This aspect of our findings, thus, has immediate practical implications. However, future longitudinal follow-up studies with these parameters investigated will show if they can provide useful incremental information with regard to prognosis and outcome (1,2).…”