Adenocarcinoma in the columnar epithelial lined lower (Barrett) oesophagus

Barrett's esophagus complicating scleroderma

“…Since Barrett's esophagus is considered a premalignant condition predisposing to the developm e n t of a d e n o c a r c i n o m a [29][30][31][32][33][34][35], its recognition in patients with scleroderma is i m p o r t a n t for identification of this high-risk group so that close follow-up can be instituted.…”

The Incidence of Esophageal Adenocarcinoma in a National Veterans Cohort With Barrett’s Esophagus

“…Th e estimated risk of progression to EA in patients with BE in the United States has been estimated in relatively small single-center studies and has been generally higher than in European cohorts, ranging from 0.23% to 2.4% per year (6)(7)(8)(9) . A multicenter prospective cohort study of 1,204 non-dysplastic BE patients, followed for a mean of 5.52 years, found that EA incidence was 1 in 370 patients (0.27% per year) ( 10 ) .…”

Barrett’s oesophagus: an ideal model to study cancer genetics

“…There is debate about the requirement for the presence of the intestinal cell type in order to diagnose Barrett's oesophagus. Early studies suggested that almost all OACs arise within intestinal metaplasia (Hawe et al 1973;Haggitt et al 1978). In keeping with this evidence, American guidelines consider the presence of intestinal metaplasia a requirement for enrolment of patients into surveillance programmes for the early detection of dysplasia and OAC .…”