Adenocarcinoma of intestinal type arising in mature cystic teratoma of ovary: A diagnostic dilemma

Belaid, I.; Khechine, W.; Abdelkader, Atef Ben; Bedioui, Ahlem; Ezzairi, Faten; Chabchoub, I.; Boujnah, Ryma; Tlili, Taghrid; Hochlaf, Makrem; Fatma, Leïla Ben; Mokni, Moncef; Ahmed, Slim Ben

doi:10.1002/ccr3.2718

Cited by 4 publications

(4 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, it should not be considered merely an ovarian tumor. The incidence of mature teratoma with malignant transformation is less than 2%[ 4 , 5 ], the most common type of malignant transformation is squamous cell carcinoma, which exceeds 80%, followed by adenocarcinoma[ 6 , 7 ]. Colorectal primary mature teratoma is extremely rare, most of which is reported as individual cases, and mostly in the rectum.…”

Section: Discussionmentioning

confidence: 99%

Malignant transformation of primary mature teratoma of colon: A case report

Liu¹

2022

WJCC

View full text Add to dashboard Cite

BACKGROUND Mature teratoma is a common benign ovarian germ cell tumor, accounting for about 20% of ovarian tumors. The malignant transformation of this tumor is less than 2%. The most common type is squamous cell carcinoma, followed by adenocarcinoma. Malignant transformation of colonic mature teratoma is extremely rare. We here report a case of malignant transformation of primary mature teratoma of the colon. The type of malignant transformation was adenocarcinoma. CASE SUMMARY A 63-year-old woman was admitted to our hospital due to persistent pain in her right lower abdomen for 1 mo, and she had no nausea, vomiting, blood in the stools, or other symptoms. Preoperative colonoscopy showed uplift of the sigmoid colon mucosa and submucosa. The biopsy showed squamous epithelium. However, contrast-enhanced computed tomography of abdomen and pelvis showed a localized thickening of the sigmoid wall, suggesting colon cancer. Endoscopic ultrasonography (EUS) revealed that the structure of the intestinal wall at the base of the lesion was destroyed, and the boundary between the lesion and the surroundings was unclear. According to the findings of the EUS, the patient did not undergo endoscopic submucosal dissection, but underwent radical resection of the tumor. Histologically, squamous epithelium was seen on the mucosal surface of the colon wall, cartilage and glands were seen under the epithelium, and adenocarcinoma was seen on the muscular layer and serous surface. The final pathological diagnosis was malignant teratoma of the colon. We have followed up the patient for 2 mo since the operation, and the patient recovered well. CONCLUSION This case suggests the possibility of mature teratoma in the colon and recognition of malignant types, and it should not be considered as an exclusively ovarian tumor.

show abstract

Section: Discussionmentioning

confidence: 99%

Malignant transformation of primary mature teratoma of colon: A case report

Liu¹

2022

WJCC

View full text Add to dashboard Cite

show abstract

“…Squamous cell carcinoma is the most common type [ 16 , 21 ]. Other less frequent malignant transformations include mucinous carcinoma [ 21 ], adenocarcinoma [ 22 , 23 , 24 , 25 , 26 ], melanoma [ 27 ], carcinoid [ 28 , 29 , 30 ], oligodendroglioma [ 31 , 32 , 33 ], and sarcoma [ 34 , 35 , 36 , 37 ].…”

Section: Epidemiologymentioning

confidence: 99%

“…Alkylating drugs were also found to be associated with significant increases in survival in tumors at stages beyond Ia in Hackethal’s study in 2008 [ 16 ]. Paclitaxel and carboplatin are used in patients with adenocarcinoma [ 22 ]. Dacarbazine (DTIC) monotherapy or combination therapy, including nitrosourea and cisplatin, may be administered as adjuvant therapies for patients with melanoma [ 27 ].…”

Section: Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

Mature Cystic Teratoma: An Integrated Review

Cong

Wang

Yeung

et al. 2023

IJMS

View full text Add to dashboard Cite

Ovarian dermoid cysts, also called mature cystic teratomas (MCTs), account for 69% of ovarian germ cell tumors in young women. The tumors are formed by tissues derived from three germ layers, and sebaceous materials are most commonly seen. The origin of MCTs is widely considered to be the germ cell origin, which completes meiosis I. The clinical symptoms vary widely, but 20% of tumors could be asymptomatic. The diagnosis of MCTs is usually made without difficulty by ultrasound and confirmed by histopathology post-operatively. The imaging findings have a high diagnostic value. The typical characteristics present in the sonographic images, including a dermoid plug or Rokitansky nodule, are considered strong evidence for a teratoma. Although the malignant transformation of MCTs is rare, it can occur in some cases, especially in women of advanced age. The treatment of MCTs depends on the risk of malignancy, the age of the patient, and the patient’s fertility reserve requirement. In this article, we review the epidemiology, clinical symptoms, diagnosis criteria, cellular origin, and treatment of mature cystic teratomas.

show abstract