Adenocarcinoma of the esophagogastric junction: Do we see more or less?

Yee, Y. K.; Wong, Benjamin C Y

doi:10.1111/j.1440-1746.2008.05565.x

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…Generally, esophageal cancer is common in heavy smokers and elderly individuals with alcohol polyposia, and some esophageal cancer patients have complications involving organ derangement (Hiyama et al , ). The number of esophageal adenocarcinoma cases has been slowly increasing and now includes approximately 70% of all esophageal cancer patients in Europe and America (Yee et al , ). The current diagnostic, screening and surveillance methods for esophageal cancer, such as upper gastrointestinal endoscopy, barium esophagrams and serology marker tests, each have certain limitations, and the detection of esophageal cancer depends on performing adequate biopsies of the esophageal mucosa, although the accuracy of tissue biopsies involving endoscopically abnormal mucosa tissue ranges from 25 to 60% (Groome et al , ).…”

Section: Introductionmentioning

confidence: 99%

Serum metabolomics as a novel diagnostic approach for gastrointestinal cancer

Ikeda

Nishiumi

Shinohara

et al. 2011

Biomedical Chromatography

147

104

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Conventional tumor markers are unsuitable for detecting carcinoma at an early stage and lack clinical efficacy and utility. In this study, we attempted to investigate the differences in serum metabolite profiles of gastrointestinal cancers and healthy volunteers using a metabolomic approach and searched for sensitive and specific metabolomic biomarker candidates. Human serum samples were obtained esophageal (n = 15), gastric (n = 11), and colorectal (n = 12) cancer patients and healthy volunteers (n = 12). A model for evaluating metabolomic biomarker candidates was constructed using multiple classification analysis, and the results were assessed with receiver operating characteristic curves. Among the 58 metabolites, the levels of nine, five and 12 metabolites were significantly changed in the esophageal, gastric and colorectal cancer patients, respectively, compared with the healthy volunteers. Multiple classification analysis revealed that the variations in the levels of malonic acid and L-serine largely contributed to the separation of esophageal cancer; gastric cancer was characterized by changes in the levels of 3-hydroxypropionic acid and pyruvic acid; and L-alanine, glucuronoic lactone and L-glutamine contributed to the separation of colorectal cancer. Our approach revealed that some metabolites are more sensitive for detecting gastrointestinal cancer than conventional biomarkers. Our study supports the potential of metabolomics as an early diagnostic tool for cancer.

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Section: Introductionmentioning

confidence: 99%

Serum metabolomics as a novel diagnostic approach for gastrointestinal cancer

Ikeda

Nishiumi

Shinohara

et al. 2011

Biomedical Chromatography

147

104

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“…Esophageal cancer is the sixth most common cause of cancer death worldwide [81]. The number of esophageal adenocarcinoma cases has been slowly increasing and now accounts for approximately 70% of all esophageal cancer patients in Europe and America [82]. Gastric cancer is the fourth most common type of cancer and the second most frequent cause of cancer death [83].…”

Section: Esophageal and Gastric Cancermentioning

confidence: 99%

Metabolome analysis for discovering biomarkers of gastroenterological cancer

Suzuki

Nishiumi

Matsubara

et al. 2014

Journal of Chromatography B

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Improvements in analytical technologies have made it possible to rapidly determine the concentrations of thousands of metabolites in any biological sample, which has resulted in metabolome analysis being applied to various types of research, such as clinical, cell biology, and plant/food science studies. The metabolome represents all of the end products and by-products of the numerous complex metabolic pathways operating in a biological system. Thus, metabolome analysis allows one to survey the global changes in an organism's metabolic profile and gain a holistic understanding of the changes that occur in organisms during various biological processes, e.g., during disease development. In clinical metabolomic studies, there is a strong possibility that differences in the metabolic profiles of human specimens reflect disease-specific states. Recently, metabolome analysis of biofluids, e.g., blood, urine, or saliva, has been increasingly used for biomarker discovery and disease diagnosis. Mass spectrometry-based techniques have been extensively used for metabolome analysis because they exhibit high selectivity and sensitivity during the identification and quantification of metabolites. Here, we describe metabolome analysis using liquid chromatography-mass spectrometry, gas chromatography-mass spectrometry, and capillary electrophoresis-mass spectrometry. Furthermore, the findings of studies that attempted to discover biomarkers of gastroenterological cancer are also outlined. Finally, we discuss metabolome analysis-based disease diagnosis.

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Therapy for Locally Advanced Adenocarcinoma of the Gastroesophageal Junction: Optimizing Outcome

Kleinberg¹

2013

Seminars in Radiation Oncology

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Adenocarcinoma of the esophagogastric junction: Do we see more or less?

Cited by 4 publications

References 17 publications

Serum metabolomics as a novel diagnostic approach for gastrointestinal cancer

Serum metabolomics as a novel diagnostic approach for gastrointestinal cancer

Metabolome analysis for discovering biomarkers of gastroenterological cancer

Therapy for Locally Advanced Adenocarcinoma of the Gastroesophageal Junction: Optimizing Outcome

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