Adenocarcinoma of the ileum in Crohn disease

Abstract

Small bowel adenocarcinoma develops in 1.5% of patients who have longstanding Crohn disease and is very rarely diagnosed preoperatively because of its rarity, overlapping imaging features, and lack of reported cases. Nonspecific findings including loss of mural stratification (i.e., "target sign") and mild degree of bowel wall enhancement when combined with enlarged mesenteric lymph nodes were helpful computed tomographic findings to suspect malignancy in our case.

Small bowel adenocarcinoma in Crohn disease: CT-enterography features with pathological correlation

“…To our knowledge, the imaging appearance of Crohn disease-related small bowel adenocarcinomas using modern imaging technique such as helical CT has been rarely reported. In addition, the reported cases were either case reports [19,20] or treated in the aggregate with more general conditions [8,21].…”

Rare Coexistance of Ileal Diverticulosis, Crohn’s Disease and Small Bowel Adenocarcinoma: Report of a Case

“…The most frequent presenting symptoms are abdominal pain, anemia, and small bowel obstruction. In most cases (88%) adenocarcinoma is found incidentally at surgery (2). JID is a rare disorder and the course of the disease is mostly asymptomatic.…”

“…The first reports of CD patients who subsequently developed cancer of the large or small intestine were published in 1948 and 1956, subsequently (3). In 1746, Hamburger made the first case report of duodenal carcinoma and the first review of malignant small bowel neoplasms was published in 1876 by Leichtenstein (2,3).…”

“…Small bowel adenocarcinoma develops in 1.5% of patients who have longstanding CD and is very rarely diagnosed preoperatively because of its rarity, overlapping imaging features and lack of reported cases (1,2). Adenocarcinoma in CD is more often poorly differentiated and has a worse prognosis than primary adenocarcinoma of small bowel.…”

“…Adenocarcinoma in CD is more often poorly differentiated and has a worse prognosis than primary adenocarcinoma of small bowel. The median age at diagnosis is 49 years (2). The first reports of CD patients who subsequently developed cancer of the large or small intestine were published in 1948 and 1956, subsequently (3).…”