Adenocarcinoma of the jejunum associated with nontropical sprue

Petreshock, Edward P.; Pessah, Marius; Menachemi, Eliyahu

doi:10.1007/bf01070840

Cited by 22 publications

(5 citation statements)

References 18 publications

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“…Cooper and associates [21] have cogently summarized the reasons for the increased incidence of malignant change and feel that the possibility of lymphoma should be considered in patients who present with either celiac disease m midlife or who deteriorate for no apparent reason after a period of stability on a gluten-free diet. Although the foregut and hindgut are the 2 common sites for adenocarcinoma developing in association with celiac disease [21], midgut lesions have also been documented [9,22]. Intestinal tymphoma has been reported as a complication of immune deficiency states [23] and it is tempting to speculate on the association between the use of immunosuppressants and lymphoma in 1 of our patients who had undergone a live donor renal transplant 12 years prior to presentation.…”

Section: Discussionmentioning

confidence: 83%

Primary jejunoileal tumors: A review of 45 cases

et al. 1991

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We reviewed 45 patients who underwent surgery for primary jejunoileal tumors over a 15-year period. There were 16 benign and 29 malignant tumors, which included 13 lymphomas, 7 adenocarcinomas, 7 carcinoid tumors, and 2 leiomyosarcomas. Eighteen patients, 13 of whom had benign tumors, presented with intestinal bleeding and 5 tumors were found incidentally at laparotomy. Benign lesions were more frequently sited in the jejunum while malignant lesions were more common in the ileum (p less than 0.001). Lesions presenting with hemorrhage were more likely to be benign than malignant (p less than 0.001) and were more commonly sited in the jejunum than in the ileum (p less than 0.05). Visceral perforation (31%), intestinal obstruction (21%), and an abdominal mass (17%) were other presenting features in patients with malignant tumors. In spite of a wide variety of investigations, the correct diagnosis was reached preoperatively in only 31% of patients. Surgical management included either limited bowel resection or segmental resection with regional lymphadenectomy. Operative mortality was 13% and morbidity was 36%. Actuarial 5-year survival for all malignant tumors was 24%, being 64% at 5 years for carcinoid tumors, 20% at 30 months for adenocarcinomas, and 10% at 42 months for lymphomas. These results reemphasize the need for a high index of suspicion and early laparotomy in patients with obscure intestinal symptoms if the prognosis of small bowel tumors is to improve.

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Section: Discussionmentioning

confidence: 83%

Primary jejunoileal tumors: A review of 45 cases

et al. 1991

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“…Such an incidence of malignancy is, of course, much higher than that expected from any control population. Between 1941 and1975, of the total of 97 deaths, 37 have been due to malignant disease, leaving little doubt that, in this series of 202 patients, there has been an increase in deaths from cancer, particularly reticulum cell sarcoma and gastrointestinal cancer.…”

Section: Discussionmentioning

confidence: 86%

“…Thus the reports of the 15 patients with adenocarcinoma of the jejunum have been reviewed by Petreshock et al (1975), while Harris et al (1967) found that the incidence ofgastrointestinal carcinoma was significantly increased, particularly oesophageal carcinoma in men.…”

mentioning

confidence: 99%

Coeliac disease, gluten-free diet, and malignancy.

Holmes¹,

Stokes²,

Sorahan³

et al. 1976

Gut

238

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“…Numerous condition:, arc predisposing facto rs fo r sma ll bowel cancer. C cliac sprue has been associated with lymphoma ( 17) anJ has been implicated in the pathogenesis of adenocarcinomas (18). Dermariris herpetiformis has a lso been assoc ia ted with a disproportionate n umber of small bowel ad enocarc inom as ( 19).…”

Section: Small Bowel Tumoursmentioning

confidence: 99%

Neoplastic Imitators of Small Bowel Crohn’s Disease

Badley

MacCormick

LeBrun

1992

Canadian Journal of Gastroenterology and Hepatology

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OBJECTIVE: To identify the problem of small bowel neoplasia masquerading as Crohn's disease. DATA AND METHODS: Sixteen articles reviewing the frequency of small bowel neoplasia were identified. Articles were selected if they assessed frequency of small bowel tumours in the general population. All articles were retrospective reviews of experience. Data on frequency were extracted and Ct)mpiled. Three case reports as illustrative examples and a Mcclline search of small bowel neoplasms with manual searching of references from identified articles arc presented. RESULTS: A total of 2507 cases of small bowel tumours was compiled. The frequency of tumours in decreasing order was adenocarcinoma, carcinoid, lymphoma, le iomyoma, le iomyosarcoma, adenoma a nd lipoma. CONCLUSIONS: Crohn's disease is the most preva lent d isease affecting terminal ileum. Malignant disease may affect the terminal small bowel in ways which are clinically indistinguishable from Crohn's disease. Surgery is the last therapeutic option for Crohn's disease, whe reas it is potent iall y curative anJ therefore the first option for small bowel neoplasia. Misdiagnos ing malignant processes as being Crohn's disease causes delays in effective treatment and worsens prognosis.

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Adenocarcinoma of the jejunum associated with nontropical sprue

Cited by 22 publications

References 18 publications

Primary jejunoileal tumors: A review of 45 cases

Primary jejunoileal tumors: A review of 45 cases

Coeliac disease, gluten-free diet, and malignancy.

Neoplastic Imitators of Small Bowel Crohn’s Disease

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