Adenocarcinoma of the lung associated with pityriasis rubra pilaris

Garretson, Cara B; Machan, Mac; Krejci‐Manwaring, Jennifer; Aires, Daniel; Tonkovic-Capin, Viseslav

doi:10.5070/d36vr5r017

Cited by 5 publications

(3 citation statements)

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“… 1 , 4 Combining the cases of paraneoplastic PRP in the literature and our cases, 11 of 19 (58%) were men and 9 of 19 (42%) were women ( Table I ). 1 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 The average age of diagnosis is 65 years, ranging from 26 to 89 years. On the basis of the findings in the literature, PRP is associated with a wide variety of neoplasms, including, but not limited to malignancies affecting the pulmonary, gastrointestinal, and hematologic systems ( Table I ).…”

Section: Discussionmentioning

confidence: 99%

“…On the basis of the findings in the literature, PRP is associated with a wide variety of neoplasms, including, but not limited to malignancies affecting the pulmonary, gastrointestinal, and hematologic systems ( Table I ). 1 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19…”

Section: Discussionmentioning

confidence: 99%

“… Vitiello 10 (2013) F 89 Adenocarcinoma of the colon Acitretin, topical steroids, emollients Near complete resolution 1 month after tumor resection. Garretson 11 (2011) M 66 Primary pulmonary adenocarcinoma Acitretin, topical steroids Complete resolution 1 week after tumor resection. Batinac 4 (2009) M 46 Laryngeal carcinoma Acitretin Complete resolution after tumor resection.…”

Section: Discussionmentioning

confidence: 99%

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Rethinking pityriasis rubra pilaris as a paraneoplastic syndrome: Two cases of pityriasis rubra pilaris with concomitant underlying malignancy

Davis¹,

Raine²,

Swartzman³

et al. 2023

JAAD Case Reports

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Rethinking pityriasis rubra pilaris as a paraneoplastic syndrome: Two cases of pityriasis rubra pilaris with concomitant underlying malignancy

Davis¹,

Raine²,

Swartzman³

et al. 2023

JAAD Case Reports

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A Review on Pityriasis Rubra Pilaris

et al. 2018

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Pityriasis rubra pilaris (PRP) is an idiopathic, papulosquamous inflammatory dermatosis. It is characterized by hyperkeratotic follicular papules coalescing into orange-red scaly plaques, islands of sparing, and palmoplantar keratoderma. PRP can be subdivided into six clinical subtypes according to Griffiths' classification, based on age of onset, disease extent, prognosis, and other associated features. The sixth subtype of PRP occurs in individuals affected by HIV infection, and retroviral screening in all de novo cases of PRP is advised. Other reported associations include various infections, autoimmunity, drugs, and malignancies, although the true significance of these is still unclear. The genetic basis for familial cases, most commonly categorized under the fifth subtype, has been mapped to gain of function mutations in the caspase recruitment domain family, member 14 (CARD14) gene. Treatment of PRP remains a challenge to this day due to a paucity of high-quality evidence. Therapeutic regimens have been guided mostly by case reports and case series, with the mainstay of treatment being oral retinoids. Recently, biologics have emerged as a promising treatment for PRP. We present a review of the clinicopathologic features, pathogenesis, associated disorders, and treatment of PRP, with an emphasis and critical appraisal of the existing literature on the latter.

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