Adenocarcinoma of the nonpigmented ciliary epithelium: report of two cases with immunohistochemical findings

Terasaki, Hiroko; Nagasaka, Tetsuro; Arai, M.; Harada, Tomoko; Miyake, Yoichi

doi:10.1007/s004170100353

Cited by 15 publications

(5 citation statements)

References 13 publications

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“…AE1 specifically recognizes the keratins in the acidic subfamily and AE3 recognizes the keratins in the basic subfamily. AE3 has been found in both nonpigmented ciliary epithelial tumor cells and non‐neoplastic cells, whereas AE1 was only expressed in tumor cells 51 . This study found the adenocarcinomas to have the highest expression of AE1/AE3 with less expression in the adenomas.…”

Section: Discussionmentioning

confidence: 60%

Immunohistochemical properties of ocular adenomas, adenocarcinomas and medulloepitheliomas

Klosterman¹,

Colitz²,

Chandler³

et al. 2006

Veterinary Ophthalmology

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A Senior Honors Thesis:Presented in partial fulfillment of the requirements for graduation with distinction in Zoology in the undergraduate college of Arts and Sciences of The Ohio State University. By Abstract:Ocular medulloepitheliomas, adenomas and adenocarcinomas share a common phenotype and originate from the cells of the ciliary epithelium. This can make it very difficult to differentiate between these tumors histopathologically. Therefore, this study focused on identifying a combination of immunological markers that might be used in the diagnosis of these tumors. These markers included AE1/AE3, CK7, CK20, and telomerase reverse transcriptase (TERT).Routine immunohistochemical staining was performed on twenty-one whole globes diagnosed with one of these tumors. The tumors that immunostained for TERT showed increasing immunoreactivity as the tumor types increased in aggressiveness. None of the tumor types were immunopositive for CK7. CK20 immunostaining was found in the adenomas but not in the adenocarcinomas or medulloepitheiomas. AE1/AE3 expression was present more consistently in the adenocarcinomas and less frequently in the adenomas. There was no AE1/AE3 expression in the medulloepitheliomas confirming their mesenchymal origin.Furthermore, CK20 and TERT show inverse expression patterns, i.e., TERT increases in expression and CK20 decreases in expression with increasing aggressiveness. These results may be important diagnostic and prognostic indicators for these tumors. (195 words)

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Section: Discussionmentioning

confidence: 60%

Immunohistochemical properties of ocular adenomas, adenocarcinomas and medulloepitheliomas

Klosterman¹,

Colitz²,

Chandler³

et al. 2006

Veterinary Ophthalmology

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“…2.2.1. Ocular tumors-NVG has been reported in association with prior to treatment in ring melanoma of the anterior uvea (Allaire et al 1997), adenocarcinoma of the nonpigmented ciliary epithelium (Terasaki et al 2001), medulloepithelioma (Singh et al 2001), circumscribed choroidal hemangioma (Shields et al 2001a), metastatic cutaneous melanoma to the vitreous (Gunduz et al 1998), retinoblastoma (De Potter 2002, and metastatic malignant lymphoma (Matsui et al 2005).…”

Section: Uncommon Ocular Causes Of Nvgmentioning

confidence: 99%

Neovascular glaucoma

Hayreh

2007

Progress in Retinal and Eye Research

225

223

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Neovascular glaucoma (NVG) is a severely blinding, intractable disease. The objective of this review is to provide detailed information on its basic and clinical aspects, to enable us to manage it logically. Therefore, its causes, pathogenesis and pathology, methods of early diagnosis and management are discussed. To prevent or reduce the extent of visual loss caused by NVG, the first essential is to have a high index of suspicion of its development. The most common diseases responsible for development of NVG are ischemic central retinal vein occlusion (CRVO), diabetic retinopathy and ocular ischemic syndrome. In the management strategy, the first priority should be to try to prevent its development by appropriate management of the causative diseases. If NVG develops, early diagnosis is crucial to reduce the extent of visual loss. Management of NVG primarily consists of controlling the high IOP by medical and/or surgical means to minimize the visual loss. Currently, we still do not have a satisfactory means of treating NVG and preventing visual loss in the majority, in spite of multiple modes of medical and surgical options advocated over the years and claims made. This review discusses the pros and cons for the various advocated treatments.

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“…In general, adenoma of the RPE is negative for HMB-45,15 in contrast to malignant melanoma. However, there is a single report of adenoma of the RPE that was positive for HMB-45 11.…”

Section: Discussionmentioning

confidence: 94%

A clinically challenging diagnosis of adenoma of the retinal pigment epithelium presenting with clinical features of choroidal hemangioma

Nakamura

Hikita

Yamakawa

et al. 2012

OPTH

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BackgroundAdenoma of the retinal pigment epithelium (RPE) is a rare intraocular tumor that can simulate other pigmented tumors such as choroidal melanoma. We report a case of non-pigmented adenoma of the RPE initially diagnosed as choroidal hemangioma.Case reportA 42-year-old woman presented to Kurume University Hospital in November 1992 with an orange-yellow tumor nasal to the optic disc in the left fundus. The tumor was 9.0 × 9.0 mm in diameter, 6.0 mm thick, and was characterized by high intensity on T1-weighted magnetic resonance imaging (MRI), low intensity on T2-weighted MRI, and enhancement on gadolinium MRI. Fluorescein angiography revealed early hypofluorescence and late hyperfluorescence of the tumor and retinal feeder vessels. By April 1996, exudate had developed around the tumor margins. The patient was treated with external beam radiation therapy (20 Gy) in July 1996, but the tumor did not diminish in size. Subsequently, she developed extensive loss of vision due to total retinal detachment. Accordingly, her left eye was enucleated in June 2005 because of severe ocular pain due to absolute glaucoma. Histopathological examination indicated that the tumor was contiguous with the normal surrounding RPE and was composed of cords and tubules of mostly non-pigmented spindle-shaped cells with round to oval nuclei and a small amount of cytoplasm containing melanin granules. The tumor cells were immunoreactive for vimentin, S-100 protein, and cytokeratin 18. The final diagnosis was adenoma of the RPE.ConclusionAdenoma of the retinal pigment epithelium may be associated with incompetent vessels leading to serous retinal detachment and extensive visual loss, and may exhibit clinical characteristics similar to choroidal hemangioma.

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Adenocarcinoma of the nonpigmented ciliary epithelium: report of two cases with immunohistochemical findings

Cited by 15 publications

References 13 publications

Immunohistochemical properties of ocular adenomas, adenocarcinomas and medulloepitheliomas

Immunohistochemical properties of ocular adenomas, adenocarcinomas and medulloepitheliomas

Neovascular glaucoma

A clinically challenging diagnosis of adenoma of the retinal pigment epithelium presenting with clinical features of choroidal hemangioma

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