Adenocarcinoma of the Urinary Bladder

Parwani, Anil V.

doi:10.5858/arpa.2009-0713-rs

Cited by 37 publications

(54 citation statements)

References 25 publications

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“…Adenokanserler metastaz veya komşu organlardan invazyon dışlandıktan sonra primer mesane köken-li kabul edilebilir. Primer vezikal adenokarsinom ekstrofik mesanede en sık görülen kanser türüdür [12]. Çoğu kötü diferansiye ve invaziftir.…”

Section: Adenokarsinomlarunclassified

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Rare malignancies of the bladder: Case series and review of the literature

Yıkılmaz¹

2014

Diclemedj

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Patients who operated the diagnosis with bladder cancer were evaluated retrospectively. Patients with a rare pathology was determined. Rare tumors of the bladder was investigated by examining the literature. Our clinic diagnosis and treatment algorithms were compared with the literature.A rare tumor of the bladder cannot be recognized by most urologists and pathologists. Therefore, it can cause difficulties during diagnosis and treatment.Key words: Bladder cancer, adenocarcinoma, signet ring cell carcinoma, squamous cell carcinoma, neuroendocrine tumors ÖZETKliniğimizde mesane tümörü tanısıyla opere edilen olgular retrospektif olarak değerlendirildi. Bu olgulardan nadir patolojiye sahip olanlar belirlendi. Literatür incelenerek mesanenin nadir görülen tümörleri araştırıldı. Kliniğimiz-deki tanı ve tedavi algoritmaları literatür ile karşılaştırıldı.Mesanenin nadir görülen tümörleri çoğu ürolog ve patolog tarafından tanınamamaktadır. Bu nedenle ilk tanı esnasında ve tedavi sırasında zorluklara neden olabilmektedir.Anahtar kelimeler: Mesane kanseri, adenokanser, taşlı yüzük hücreli kanser, yassı hücreli kanser, nöroendokrin tümörler GİRİŞMesane kanseri tüm kanserler içinde 9. üriner sistem tümörleri içinde ise 2. sıklıkta görülmektedir. Dün-ya Sağlık Örgütü'nün 1973'de yaptığı sınıflamada kanserin %90-95'inin değişici epitel (tranzisyonel) kanserleri %5-10'unun ise mezenkimal ve/veya epitelyal kaynaklı olduğu belirtilmiştir [1]. Bunlar arasında da en sık yassı hücreli ve adenokanserler bulunmaktadır. Non-ürotelyal kanserlerin tanısı ço-ğunlukla ileri evrede konulmakta ve cerrahiye ek tedavi ihtiyacı doğurmaktadır. Klinik şikayetleri üro-telyal kansere benzer şekilde makroskopik pıhtılı hematüri ve irritatif işeme semptomlarıdır. Bunlara özel bir sınıflama sistemi olmayıp TNM sınıflaması kullanılmaktadır [2]. Bazı patolojik tipler çok nadir olmaları nedeniyle çoğu patolog tarafından tanına-mamaktadır. Yassı hücreli kanserMesanenin skuamöz hücreli kanseri Batı toplumlarında mesane kanserlerinin %1-3'ünü oluştururken, Mısır'da %75'inden sorumludur. Kronik olarak maruz kalınan Şistozoma hematobiyum enfeksiyonu en sık nedenidir. Skuamöz hücreli kanser deği-şici hücreli kansere göre daha genç hastalarda gö-rülmektedir. Bu kanserler ekzofitik, nodüler veya dallanan lezyonlar olup genellikle iyi diferansiyedirler. Metastaz eğilimleri düşüktür. Şistozoma hematobiyum enfeksiyonu dışında taş, üriner kateterizasyon, mesane divertikülü, kronik enfeksiyon ve kronik irritasyona bağlı da skuamöz hücreli kanser gelişebilmektedir. Spinal kord yaralanmalı hasta grubunda %2,5-10 oranında skuamöz hücreli kanser gelişmekteyken son yıllarda kaliteli kateterlerin kullanılmasıyla bu oran %0,38'e düşmüştür. Daimi sondalı takip edilen paraplejik hastalarda görülen mesane tümörlerinin %80'i skuamöz hücreli kan-

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Section: Adenokarsinomlarunclassified

“…Prostatik adenokarsinomlardan ayrımında PSA oldukça faydalıdır. Kötü diferansiye prostatik adenokarsinomaların %90'ında pozitiftir [12]. Olgumuzda prostat adenokarsinom araştırıl-mış ve patoloji bulunamamıştır.…”

Section: Olguunclassified

Rare malignancies of the bladder: Case series and review of the literature

Yıkılmaz¹

2014

Diclemedj

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“…1,[4][5][6] Therefore, distinguishing them from the secondary involvement of the urinary bladder by adenocarcinoma of another organ, especially the colon, is often challenging or impossible by light microscopy alone. 6 Although immunohistochemical markers such as CK7, CK20, villin, CDX-2, and b-catenin have been proposed to aid in resolving the differential diagnosis of these tumors, limitations in sensitivity and specificity have prevented any single marker or small panel of markers from emerging as clearly superior.…”

mentioning

confidence: 99%

Distinguishing primary adenocarcinoma of the urinary bladder from secondary involvement by colorectal adenocarcinoma: extended immunohistochemical profiles emphasizing novel markers

et al. 2013

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Glandular neoplasms involving the urinary bladder carry a challenging differential diagnosis including primary and secondary processes. We investigated the potential diagnostic utility of cadherin-17 and GATA3 in 25 primary adenocarcinomas of the urinary bladder, as compared with other commonly used markers including b-catenin and p63. Urothelial carcinoma with glandular differentiation (11), colorectal adenocarcinoma secondarily involving the bladder (25), and primary colorectal adenocarcinoma (22) were also analyzed and the results were compared using a Fisher exact test. Cadherin-17 was expressed in 23/25 primary bladder adenocarcinomas (92%), 23/25 colorectal adenocarcinomas involving the bladder (92%), 21/22 primary colorectal adenocarcinomas (95%) and entirely negative (0/11) in both components of urothelial carcinoma with glandular differentiation (Po0.001). In urothelial carcinoma with glandular differentiation, positive nuclear staining for GATA3 was evident in the urothelial component for 18% (2/11) and the glandular component for 9% (1/11) with additional tumors showing only cytoplasmic staining. Nuclear reactivity for GATA3 was not present in primary bladder adenocarcinoma and primary/secondary colorectal adenocarcinoma (Po0.05). Positive nuclear and cytoplasmic immunostaining for b-catenin was evident in 21/22 primary colorectal adenocarcinomas (95%) and 23/25 cases of secondary involvement by colorectal adenocarcinoma (92%). In contrast, positive membranous and cytoplasmic staining for b-catenin was observed in 23/25 primary bladder adenocarcinomas (92%) and 11/11 urothelial carcinomas with glandular differentiation (100%, Po0.001). p63 was expressed only in the urothelial component of urothelial carcinoma with glandular differentiation and not in the glandular component (Po0.001). In summary, cadherin-17 is a relatively specific and sensitive marker for primary adenocarcinoma of the urinary bladder, distinguishing it from urothelial carcinoma with glandular differentiation. However, it does not distinguish primary bladder adenocarcinoma from secondary involvement by colorectal adenocarcinoma. The pattern of reactivity for b-catenin remains the most useful marker for distinguishing these two tumors.

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“…Adenocarcinoma may be classified into three groups, consisting of the primary vesicle, urachal and metastatic adenocarcinomas (12). Metastatic adenocarcinoma is one of the most common forms of adenocarcinoma (15). The diagnosis, treatment and prognosis of metastatic adenocarcinoma are closely associated with the primary site, which may include the rectum, stomach, endometrium, breast, prostate or ovary (6).…”

Section: Discussionmentioning

confidence: 99%

Primary adenocarcinoma of the renal pelvis, ureter and the urinary bladder: A case report and review of the literature

2016

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Abstract. Primary adenocarcinoma is a rare type of urological neoplasm. The present study reports the case of a 55-year-old man with multifocal adenocarcinoma of the renal pelvis, ureter and urinary bladder that occurred in association with a large cystic calculus and perinephric abscess. The patient had suffered from gross hematuria for 2 years and right flank pain for 2 months. Following a series of investigations, a large cystic calculus with multiple tumors in the renal pelvis and ureter was identified. Multifocal tumors and a large calculus were located in the bladder using a cystoscope. The pathological report of 3 individual biopsies revealed a moderately differentiated tubular adenocarcinoma. Right nephrectomy, ureterectomy, radical cystectomy and left ureterocutaneostomy were performed. The pathological investigation revealed a moderately differentiated adenocarcinoma of the renal pelvis, ureter and urinary bladder. No additional treatment was administered and the patient remains alive at follow-up without disease recurrence or metastasis. Although uncommon, the development of a tumor is possible in patients that possess long-standing urolithiasis, particularly when accompanied by hydronephrosis or infection.

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Adenocarcinoma of the Urinary Bladder

Cited by 37 publications

References 25 publications

Rare malignancies of the bladder: Case series and review of the literature

Rare malignancies of the bladder: Case series and review of the literature

Distinguishing primary adenocarcinoma of the urinary bladder from secondary involvement by colorectal adenocarcinoma: extended immunohistochemical profiles emphasizing novel markers

Primary adenocarcinoma of the renal pelvis, ureter and the urinary bladder: A case report and review of the literature

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