Adenocarcinoma of the Uterine Cervix: Cytological Evidence of a Long Preclinical Evolution

Boddington, Michael M.; Spriggs, A. I.; Cowdell, R. H.

doi:10.1111/j.1471-0528.1976.tb00770.x

Cited by 38 publications

(17 citation statements)

References 3 publications

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“…In 18 (42%) patients, the smear was normal, including four of five cases in which the cancer was occult. In a review of previous negative smears in 13 women with invasive adenocarcinoma, Boddington et al 7 found abnormalities in smears from 6 patients 2 to 8 years before diagnosis. In these cases the Ayre spatula alone was used.…”

Section: Discussionmentioning

confidence: 99%

Papanicolaou Smear Sensitivity for Adenocarcinoma In Situ of the Cervix:A Study of 34 Cases

Lee¹,

Minter²,

Granter³

1997

Am J Clin Pathol

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The sensitivity of cervical smears for adenocarcinoma in situ (AIS) is not known, nor is it known whether false-negative smears are due to sampling or to screening or interpretive errors. In 16 of 34 patients with AIS, 38 negative smears were reported 2 weeks to 7 years before biopsy. Thirty-one of these negative smears were rescreened, and 17 (55%) were retrospectively diagnosed as abnormal. The purpose of this study was to obtain an estimate of Pap smear sensitivity for AIS and to uncover difficulties in interpretation of smears that may have led to false-negative diagnoses. MATERIALS AND METHODS The surgical p a t h o l o g y files of Brigham andWomen's Hospital, Boston, were searched for case reports of AIS or AIS combined with squamous cervical intraepithelial neoplasia (CIN) with a complete cone biopsy, hysterectomy, or both for the years 1986 to 1995. All available smears diagnosed as negative before an initial biopsy confirming AIS were confirmed sampling errors. The sensitivity of cervical smears for AIS was 55% to 72%. Improved sampling of the endocervical canal offers cytologists the opportunity to diagnose AIS. This study demonstrates that this opportunity may not be fully exploited. Small "endometrioid" AIS cells and AIS cells resembling reactive endocervical cells may be mistaken for benign cells, thus decreasing sensitivity.

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Section: Discussionmentioning

confidence: 99%

Papanicolaou Smear Sensitivity for Adenocarcinoma In Situ of the Cervix:A Study of 34 Cases

Lee¹,

Minter²,

Granter³

1997

Am J Clin Pathol

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“…[15][16][17][18] With the advent of superior endocervical sampling, cytologists are presented with glandular and squamous precursor lesions characterized by cells that are sometimes smaller and less differentiated than those previously experienced. These presentations are similar to the native epithelium in the upper endocervical canal, sometimes with tubal or tuboendometrial metaplasia, and from cells inadvertently procured from the endometrium.…”

Section: Discussionmentioning

confidence: 99%

Adenocarcinoma In Situ in Cervical Smears With a Small Cell (Endometrioid) Pattern:Distinction From Cells Directly Sampled From the Upper Endocervical Canal or Lower Segment of the Endometrium

et al. 1998

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“…Precise data on incidence and survival rates of early stage adenocarcinoma are not available because of different definitions and diagnoses and because of limited follow-up information. 1'v17- 20 In this series, the criteria of early stage adenocarcinoma were defined strictly. In order to exclude the influence of squamous cell carcinoma or undifferentiated carcinoma components, and to investigate the nature and histogenesis of the "pure" type of early stage adenocarcinoma, cases coexisting with invasive squamous cell carcinoma (including microinvasive squamous cell carcinoma) or with undifferentiated carcinoma, were excluded from the category of early stage adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

Early stage adenocarcinoma of the uterine cervix histopathologic analysis with consideration of histogenesis

Teshima¹,

Shimosato²,

Kishi³

et al. 1985

Cancer

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Thirty cases of early stage adenocarcinoma, 5 mm or less in depth, were selected from 1942 primary carcinomas of the uterine cervix for histologic analysis to clarify their histogenesis. There were 16 carcinomas of endocervical type, 12 of endometrioid type, and 2 clear cell carcinomas. There were 22 early invasive adenocarcinomas and 8 adenocarcinomas in situ. In 27 cases the carcinoma was adjacent to the transformation zone and in 3 it was separate from it. In 10 cases adenocarcinoma coexisted with in situ squamous cell carcinoma. Only one patient whose tumor was 3 mm in depth developed a pelvic recurrence after radical hysterectomy. All other patients remained disease‐free after treatment by hysterectomy. It is suggested that most adenocarcinomas of the uterine cervix originate from endocervical glands adjoining the transformation zone and that they may develop directly from normal‐appearing epithelium without passing through adenomatous or dysplastic changes.

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Adenocarcinoma of the Uterine Cervix: Cytological Evidence of a Long Preclinical Evolution

Cited by 38 publications

References 3 publications

Papanicolaou Smear Sensitivity for Adenocarcinoma In Situ of the Cervix:A Study of 34 Cases

Papanicolaou Smear Sensitivity for Adenocarcinoma In Situ of the Cervix:A Study of 34 Cases

Adenocarcinoma In Situ in Cervical Smears With a Small Cell (Endometrioid) Pattern:Distinction From Cells Directly Sampled From the Upper Endocervical Canal or Lower Segment of the Endometrium

Early stage adenocarcinoma of the uterine cervix histopathologic analysis with consideration of histogenesis

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