Adenocarcinoma of the uterine cervix

Leminen, Arto; Paavonen, Jorma; Forss, M.; Wahlström, Torsten; Vesterinen, E

doi:10.1002/1097-0142(19900101)65:1<53::aid-cncr2820650112>3.0.co;2-0

Cited by 80 publications

(39 citation statements)

References 15 publications

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“…Temporal misclassification between adenocarcinoma and squamous cell carcinoma could have occurred, but it is unlikely that this had had an important impact on trends. Better histological specification of cervical cancer over time has been documented (Kjaer and Brinton, 1993;Leminen et al, 1990) and, although this could also have increased the number of squamous cell carcinomas, the impact on the reported incidence rates of adenocarcinomas should be greater because of the smaller number of cases. It remains difficult to explain why this effect, if important, would be confined to younger women in recent birth cohorts.…”

Section: Strengths and Caveats In The Interpretation Of Cervical Cancsupporting

confidence: 64%

International trends in the incidence of cervical cancer: I. Adenocarcinoma and adenosquamous cell carcinomas

Vizcaino¹,

Bosch²,

Muñóz³

et al. 1998

Int. J. Cancer

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Time trends in the incidence of cervical adenocarcinoma and adenosquamous cell carcinomas during the period 1973-1991 were examined using data provided by 60 populationbased cancer registries from 32 defined populations in 25 countries. Three components of the incidence trend were studied: age, calendar period of diagnosis and birth cohort. Cumulative incidence rates per 1,000 for 2 groups with age ranges 25-49 and 50-74 years were calculated from the model that best described the incidence data. There was a significant increase in the cumulative incidence of cervical adenocarcinomas in women born in the mid-1930s and in successive cohorts thereafter in some populations in the United States (whites and Hispanic women), Australia, New Zealand (non-Maori), England, Scotland, Denmark, Slovenia, Slovakia and Japan (Osaka) and among Chinese women in Singapore, with a general decline in the incidence in women born in earlier periods. In Sweden and Slovenia there is a suggestion of an increasing trend in both age groups. A decrease in incidence in both age groups was apparent in Finland, France and Italy. There were no changes in incidence in 24 registries covering other European, Asian and black populations in the United States. Part of the increase may be attributable to an increasing prevalence of human papillomavirus infection, and part to improvements in screening. Int. J. Cancer 75:536-545, 1998.1998 Wiley-Liss, Inc.In most Cancer Registries, close to three-fourths of cervical cancer cases are reported as squamous cell carcinomas. Adenocarcinoma and adenosquamous cell carcinomas represent 10-15% and cervical cancer with ''other or without'' specified histology represent the remaining 10-15%. During the last decade, several studies have reported increasing incidence rates of cervical adenocarcinomas, particularly for young women, in countries such as the United States (Peters et al., 1986;Schwartz and Weiss, 1986;Devesa et al., 1989;Zheng et al., 1996), England and Wales (Chilvers et al., 1987), Norway (Eide, 1987) and Sweden (Bergström et al., personal communication). The reasons for the increases are poorly understood. It is possible that some of the observed increase is due to trends in the proportion of cases histologically verified, changes in disease classification over time and increased detection of early asymptomatic lesions. However, the magnitude of the changes observed are generally too great to be entirely ascribed to such effects.The purpose of our work was to examine, on a worldwide basis, time trends in the incidence of cervical adenocarcinomas, especially in young women. The analyses include incidence data provided by 60 Cancer Registries for 32 defined populations in 25 countries over a median 18-year period (range, 10-30 years). The data permit comparison of time trends in different geographic areas as well as for different ethnic groups within a given country. The analyses of the secular trends in the incidence of squamous cell carcinomas will be presented in a separate report. MATERIAL AND M...

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Section: Strengths and Caveats In The Interpretation Of Cervical Cancsupporting

confidence: 64%

International trends in the incidence of cervical cancer: I. Adenocarcinoma and adenosquamous cell carcinomas

Vizcaino¹,

Bosch²,

Muñóz³

et al. 1998

Int. J. Cancer

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“…First described by Friedell in 1953 [7] and subsequently shown to have a propensity for late recurrence and the development of invasive adenocarcinoma [22], ACIS represents approximately 9-25% of adenocarcinomas of the cervix [5,14], which account for 8-26% of cervical carcinomas [11,20,21]. Patients with ACIS have a similar epidemiologic profile to those with invasive adenocarcinoma of the endocervix [3,4,16].…”

Section: Introductionmentioning

confidence: 99%

Differential expression of MUC2 and MUC5AC in benign and malignant glandular lesions of the cervix uteri

et al. 2000

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The expression of mucin genes in the normal glandular epithelium of the endocervix has been well characterized. However, mucin gene expression in neoplastic or particular non-neoplastic glandular cervical lesions has not been addressed. This immunohistochemical study was carried out to analyze the expression of MUC2 and MUC5AC in neoplastic and non-neoplastic glandular lesions of the cervix. Monoclonal antibodies were used on paraffin-embedded sections from 41 adenocarcinomas, 2 adenosquamous carcinomas, 13 adenocarcinomas in situ (ACIS), 3 glandular dysplasias, 8 endometrioses, 5 tubal metaplasias, 17 squamous metaplasias, 3 microglandular hyperplasias and normal tissue of the endocervix, endometrium and fallopian tube. The patterns of expression of MUC2 and MUC5AC were different and in principle contrary. Focal MUC2 expression was observed almost exclusively in neoplastic lesions (36%) and not in normal epithelia and non-neoplastic lesions, the one notable exception being immature metaplasia. In contrast, strong expression of MUC5AC was observed in both normal endocervical epithelium (100%) and neoplastic lesions (73%). The expression of MUC5AC, however, was diminished in most neoplastic glandular lesions. Co-expression of MUC2 and MUC5AC was consistently documented in the lesions with intestinal differentiation. In contrast, cases of tubal metaplasia and endometriosis were negative for MUC2 and MUC5AC. These results indicate that discrimination of mucin gene expression may be helpful in discriminating lesions of the cervix.

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“…Studies have shown that over the past three decades, SCC of the cervix has been progressively decreasing in proportion to the increase of adenocarcinoma, also found in our study [13][14][15][16][17]. However, in a more current reality, this can be explained due to the better public access to the examination of cervical cytological screen- ing.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Histopathological Comparison of Two Historical Series of 142 Wertheim-Meigs Operations Performed in a Reference Center in Brazil

Filho¹

2017

Int J Womens Health Wellness

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Adenocarcinoma of the uterine cervix

Cited by 80 publications

References 15 publications

International trends in the incidence of cervical cancer: I. Adenocarcinoma and adenosquamous cell carcinomas

International trends in the incidence of cervical cancer: I. Adenocarcinoma and adenosquamous cell carcinomas

Differential expression of MUC2 and MUC5AC in benign and malignant glandular lesions of the cervix uteri

Clinical and Histopathological Comparison of Two Historical Series of 142 Wertheim-Meigs Operations Performed in a Reference Center in Brazil

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