Adenocarcinomas of the colon and rectum in persons under 40 years old

A population-based study of colorectal cancer histology in the United States, 1998–2001

“…26 These 2 registries have the largest combined Asian/Pacific Islander and Hispanic population among all the SEER registries (62% for Hawaii and 54% for Los Angeles). 27 Our results also show that age is an important factor in CRC histology and confirm several previous reports of increased proportions of mucin-producing adenocarcinomas, [28][29][30][31][32] signet ring cell tumors, 6,32,33 and carcinoid tumors 20,34 in younger individuals. In addition to the histologic types listed earlier, more sarcomas occurred in individuals under age 40.…”

Epidemioclinical Feature of Early-Onset Colorectal Cancer at-Risk for Lynch Syndrome in Central Iran

“…This study among other Eastern studies has shown that Early-onset CRC (less than 50 years of age at diagnosis) covers almost one fourth of all CRC cases in the country. This is different from Western countries where the rates of early-onset CRC include less than 10% of all CRC cases (Griffin et al, 1991;Mitry et al, 2001;Yuen et al, 2002;Claes et al, 2005;Yazdizadeh et al, 2005;Ansari et al, 2006;Dolatkhah et al, 2015). Given the changing of life style in developing societies like Iran toward westernization, in particular within youth, incident rate of early-onset CRC has been increased in these populations during the recent decades (Fatemi et al, 2010;Safari et al, 2013;Dolatkhah et al, 2015).…”

Colorectal cancer in the young, many questions, few answers

“…Gender based analysis of CRC in young patients revealed an equal prevalence in young men and women [22] contradicting the theory that female hormones are protective of colon and rectal cancer. Furthermore, a 1991 study of young patients in North America showed that the disease occurred in 34% more black men and 45% more black women compared with white Caucasian counterparts [23] . Most young patients did not report a family history of CRC; O'Connell et al [22] revealed that only 23% of young patients with CRC reported the presence of cancer in a family member.…”