Adenoid ‘ameloblastoma’: Clinicopathological description of 4 additional BRAF-negative cases

Khalaj, Fattaneh; Cinel, Leyla; Aminishakib, Pouyan; Mosavat, Farzaneh; Tekkeşın, Merva Soluk

doi:10.1016/j.jormas.2023.101585

Cited by 3 publications

(1 citation statement)

References 19 publications

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“…The word “ameloblastoma” from adenoid ameloblastoma is justified histopathologically by the presence of ameloblast-like cells showing intense, focal expression of calretinin, a specific marker for neoplastic ameloblastic epithelium [ 10 ]. However, these ameloblast-like cells fail to express BRAF p.V600E, the most common activating mutation seen in mandibular ameloblastoma [ 11 , 12 ]. The pathology was categorized as a separate entity of benign epithelial odontogenic tumor rather than a subvariant of ameloblastoma [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Histopathological Insight of a Case of Adenoid Ameloblastoma: A Rare Odontogenic Tumor

Keshwar,

Raut,

Jain

et al. 2024

Case Reports in Dentistry

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Adenoid ameloblastoma with dentinoid had been perceived as a rare odontogenic tumor with bridging histopathological features between ameloblastoma and adenomatoid odontogenic tumor. Due to the mixture of histopathological features of two separate and well-recognized entities, adenoid ameloblastoma was also regarded as a hybrid lesion. The diversity in the histopathological presentation among the cases has disaccorded the nature, behaviour, and prognosis of this pathology. Despite the literature acknowledging the histopathological diversity, categorizing all these variations into one and addressing them as a single entity was lagging till the 5th edition of the odontogenic tumor classification by the WHO was forwarded. With the establishment of the new terminology of adenoid ameloblastoma and the enlistment of its diagnostic criteria, the scientific literature has advocated updating, contributing, and redefining the various aspects of this pathology. Here, we present a case of a 34-year-old male who presented with a chief complaint of swelling in the lower front region of his jaw in the past one month. The swelling was associated with pain that was sudden in onset with a progressive increase in size. The swelling was also associated with discharge that resembled pus. A panoramic radiograph showed a mixed radiopaque and radiolucent area, extending from the distal aspect of 32 up to the distal aspect of 43. The entire cystic lining along with the growth was excised and sent for histopathological examination. Correlating clinically, the histopathological features are suggestive of adenoid ameloblastoma. Scientific literature has stood as a boon to evidence-based practice. The diagnosis for the present case report is truly an outcome of the literature-based update which helped the diagnosis of the case as a separate entity rather than as a hybrid pathology. The goal was to enhance the understanding of the lesions in terms of their clinical characteristics and diverse histopathological morphology.

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Section: Introductionmentioning

confidence: 99%

Histopathological Insight of a Case of Adenoid Ameloblastoma: A Rare Odontogenic Tumor

Keshwar,

Raut,

Jain

et al. 2024

Case Reports in Dentistry

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Adenoid ameloblastoma revisited: A discursive exploration of its histological dualism, molecular aberrations, and clinical recurrence

Deorah,

Gupta

2024

Seminars in Diagnostic Pathology

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The evolving molecular characterisation, histological criteria and nomenclature of adenoid ameloblastoma as a World Health Organisation tumour type

Odell,

Gomes,

Thavaraj

2024

Histopathology

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Adenoid ameloblastoma (AA) was recently recognised as a separate tumour type in the most recent World Health Organisation (WHO) classification of head and neck tumours. This decision has been considered controversial by several groups, who have described AA as a subtype of ameloblastoma, a hybrid odontogenic tumour or to fall within the spectrum of other recognised odontogenic tumours, including dentinogenic ghost cell tumour and adenomatoid odontogenic tumour. Here we review the reasons for the WHO decision to classify AA as a separate tumour type. We also critique molecular and histological findings from recent reports published since the WHO classification. While acknowledging that the classification of tumours is constantly evolving, the balance of current evidence suggests that AA should remain a distinct tumour type, and not a subtype of ameloblastoma, pending further molecular characterisation.

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Adenoid ‘ameloblastoma’: Clinicopathological description of 4 additional BRAF-negative cases

Cited by 3 publications

References 19 publications

Histopathological Insight of a Case of Adenoid Ameloblastoma: A Rare Odontogenic Tumor

Histopathological Insight of a Case of Adenoid Ameloblastoma: A Rare Odontogenic Tumor

Adenoid ameloblastoma revisited: A discursive exploration of its histological dualism, molecular aberrations, and clinical recurrence

The evolving molecular characterisation, histological criteria and nomenclature of adenoid ameloblastoma as a World Health Organisation tumour type

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