Adenoid Cystic Carcinoma of Bartholin's Gland: A Review of the Literature and Report of a Patient

DePasquale, Stephen; McGuinness, Timothy B.; Mangan, Charles E.; Husson, Michael A.; Woodland, Mark

doi:10.1006/gyno.1996.0109

Cited by 49 publications

(33 citation statements)

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“…[139][140][141][142] Complex chromosomal changes have been reported in one case of adenoid cystic carcinoma of the Bartholin gland. 141 Rarely, the tumor can arise from Skene glands.…”

Section: Mammary-like Anogenital Glandsmentioning

confidence: 99%

Vulvar Adnexal Lesions: A 32-Year, Single-Institution Review From Massachusetts General Hospital

Baker

Selim

Hoang

2013

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Because the skin and modified mucosal surfaces of the vulvar region contain dense apocrine glands and anogenital mammary-like glands, in addition to eccrine glands and folliculosebaceous units, benign as well as malignant lesions derived from these adnexal structures are, not surprisingly, found in the vulva. However, their incidence occurring in the vulva has not been reported, to our knowledge.Objective.-To determine the incidence of various vulvar adnexal lesions.Design.-We performed a retrospective review of the cases at our institution.Results.-A total of 189 vulvar adnexal lesions were identified. Most of these lesions were benign (133 of 189; 70%), with hidradenoma papilliferum being the most common, followed by syringoma and various types of cysts. Rare cases of tubular adenoma, poroma, spiradenoma, hidradenoma, cylindroma, sebaceoma, and trichoepithelioma were identified. Malignant adnexal neoplasms comprised the remaining 30% (56 of 189) of the cases. Extramammary Paget disease was the most common (49 of 56), and 29% (14 of 49) demonstrated an invasive component. Rare cases of basal cell carcinoma, sebaceous carcinoma, apocrine carcinoma, adenoid cystic carcinoma, and spiradenocarcinoma were identified.Conclusions.-In this retrospective review, we identified several benign entities that have not been previously reported on the vulva, namely pilomatricoma, poroma, spiradenoma, and sebaceoma. Hidradenoma papilliferum and extramammary Paget disease were the most common benign and malignant adnexal neoplasms, respectively. The spectrum of various vulvar adnexal lesions appears to reflect the frequency of the underlying glandular elements.

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“…[139][140][141][142] Complex chromosomal changes have been reported in one case of adenoid cystic carcinoma of the Bartholin gland. 141 Rarely, the tumor can arise from Skene glands.…”

Section: Mammary-like Anogenital Glandsmentioning

confidence: 99%

Vulvar Adnexal Lesions: A 32-Year, Single-Institution Review From Massachusetts General Hospital

Baker

Selim

Hoang

2013

Archives of Pathology &Amp; Laboratory Medicine

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“…Metastasis to the inguinal femoral lymph nodes is uncommon. It is probably prudent to use 10-to 15-year survival rates rather than 5-year survival curves when evaluating therapy for this tumor [2,7,8]. According to Copeland et al [7] and Lelle et al [10], the 10-year progression-free interval was 38 and 33%, respectively, compared to a survival rate of 59 and 100%, respectively, confirming a protracted although malignant clinical course of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…Associated symptoms such as pain, burning sensation, bleeding, and discharge are usual, but a vulval mass may exist for a long time before the onset of symptoms. The tumor has a protracted [2] but malignant clinical course, with a propensity for local recurrence. Its physical history is relatively slow and local recurrence and distant metastases by intravascular spread may occur over a long period of time [10].…”

Section: Discussionmentioning

confidence: 99%

“…Various histological types have been reported: adenocarcinoma, squamous, adenosquamous, transitional cell carcinoma, and adenoid cystic carcinoma, the latter accounting for approximately 5-15% of all Bartholin's gland malignancies [2,4]. To date, over 50 cases of adenoid cystic carcinoma have been reported in the literature [1][2][3][5][6][7][8][9][10][11][12]. Adenoid cystic carcinoma of Bartholin's gland is characterized by slow growth, local invasion, and sometimes distant metastasis.…”

Section: Introductionmentioning

confidence: 99%

“…Primary carcinoma of the Bartholin's gland is an uncommon neoplasm accounting for 0.1-7% of all vulvar carcinomas and less than 1% of all female genital malignancies [1][2][3]. Various histological types have been reported: adenocarcinoma, squamous, adenosquamous, transitional cell carcinoma, and adenoid cystic carcinoma, the latter accounting for approximately 5-15% of all Bartholin's gland malignancies [2,4].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Adenoid Cystic Carcinoma of Bartholin’s Gland

Nasu¹,

Kawano²,

Takai³

et al. 2005

Gynecol Obstet Invest

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Adenoid cystic carcinoma of Bartholin’s gland is characterized by slow growth, local invasion, and sometimes distant metastasis. There is no consensus regarding the optimal treatment. We report herein a rare case of stage II adenoid cystic carcinoma of Bartholin’s gland that was successfully treated by wide local excision of the tumor and ipsilateral inguinal and pelvic lymphadenectomy. A 54-year-old Japanese woman was admitted complaining of painless, gradually increasing vulvar mass existing from ten years before. Local examination revealed a 3 × 2-cm hard mass in the left labium major. Pathological examination of subsequent excisional biopsy revealed adenoid cystic carcinoma originating in the Bartholin’s gland. A wide local resection of the tumor with inguinal and pelvic lymphadenectomy was performed. The tumor was completely excised with free margins. There was no metastasis in the resected lymph nodes. The patient was diagnosed as having stage II vulvar cancer according to the International Federation of Gynecologists and Obstetricians classification (1988). The patient is now healthy without evidence of recurrence at 5 years after surgery. Adenoid cystic carcinoma of Bartholin’s cyst at early stage can be treated by wide local excision as a primary surgery.

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