Adenoid cystic carcinoma of buccal mucosa: A report of two rare cases and review of literature

Abstract

Adenoid cystic carcinoma (AdCC) is a malignant tumor mostly occurring in the head and neck salivary glands. In this article, two rare cases of adenoid cystic carcinoma occurring in the buccal mucosa with their treatment and long-term follow-up are presented. Adenoid cystic carcinoma (AdCC) was initially described as "cylindroma" in 1856 by Billroth, as it contained long amorphous compartments named "cylinders" in its histological view. Later on, the term "adenoid cystic carcinoma"(AdCC) replaced the term cylindroma for defining this tumor. 1 AdCC accounts for 10% of salivary gland tumors and for approximately 1% of all malignancies of the head and neck. 2 AdCC arises more frequently in minor salivary glands, in comparison with major salivary glands. 3 AdCC of minor salivary glands is believed to have a worse prognosis, compared to those of the major salivary glands. Pain can be a paramount symptom of the disease, due to the tumor's proneness toward perineural invasion. 4 Although this tumor is likely to occur at almost any age, it is most commonly observed in women, in the 5th and 6th decades of life. 5 In a recent study, the AdCC occurrence rate in women and men was 60:40, respectively. 6 AdCC often manifests itself as a small and slowly growing tumor. However, it is diagnosed at an advanced stage in

Unusual presentation of adenoid cystic carcinoma (ACC) on lip mimicking mucocele: A rare case report with review

“…Tumours limited to lips without neural invasion can show good results as in the present case. [ 2 , 3 , 5 ] Our case was followed-up for 6 months after surgery and showed no recurrence or complications.…”

“…Its clinical course is relentless and usually has a fatal outcome’. [ 3 ] ACC is a rare epithelial tumour with a nonfunctional but persistent growth pattern. ACC occurs predominantly in the fourth to sixth decade of life with a slight female predilection.…”

“…in 1976. [ 6 ] The differential diagnosis of ACC includes PLGA, basal cell adenoma, mixed tumour, basaloid squamous cell carcinoma[ 3 ], and mucocele (James A and Gunasekaran N et al . 2021).…”

“…Tumour is graded according to microscopic appearance, cribriform or tubular (grade I), <30% solid (grade II), or >30% solid (grade III). [ 3 ] Possible treatment choices for ACC are surgical excision, radiotherapy, chemotherapy, and combined therapy. The most common treatment choice is excision with the widest surgical margins, possible as tumour cells extend well beyond the clinical and radiographic margins to prevent a recurrence.…”

Cutaneous adenoid cystic carcinoma: clinical conundrum of a lower limb mass

“…ACC is a rare malignancy thought to account for 10% of all salivary gland malignancies. [4][5][6][7][8][9] In 60-70% of cases the minor salivary glands are affected. 4,5,[7][8][9] Occasionally rare cases can originate from the extra-salivary tissues.…”