Adenoid cystic carcinoma of palate: A case report and review of literature

Abstract

Adenoid cystic carcinoma is an uncommon, slow growing malignant salivary gland tumor that is characterized by wide local infiltration, perineural spread, propensity to local recurrence and distant metastasis. In this paper, the authors present a case of adenoid cystic carcinoma affecting the palate and involving the maxillary sinus in a 60-year-old male patient along with a brief review of literature.

Coincidentally Identified Case of Minor Salivary Gland Adenoid Cystic Carcinoma

“…But they have high recurrence rates and may develop distant metastases. So, radical surgical resection with wide margins is performed for treatment of these tumors [7][8][9][10][11][12]. There are conflicting reports on the role of postoperative radiotherapy in local control of these tumors [13].…”

Tracheolaryngeal Adenoid Cystic Carcinoma: The tumour that almost took her breath away

“…While distinction between polymorphous low-grade adenocarcinomas and ADCCs can be challenging, the Ki-67 index is 10 times higher for the latter. 4 In addition, smooth muscle markers of myoepithelial differentiation are positive in cases of ADCC but negative for polymorphous low-grade adenocarcinomas. Pseudocysts are usually positive with periodic acid-Schiff and Alcian blue stains and contain basement membrane components.…”

“…3 The differential diagnosis for ADCC includes polymorphous low-grade adenocarcinomas, basal cell adenomas, mixed tumours and basaloid squamous cell carcinomas. 4 A cribriform pattern of tumour cells is typical of ADCC; however, this pattern is rarely seen in basal cell adenomas, basaloid squamous cell carcinomas and mixed tumours. While distinction between polymorphous low-grade adenocarcinomas and ADCCs can be challenging, the Ki-67 index is 10 times higher for the latter.…”

“…Pseudocysts are usually positive with periodic acid-Schiff and Alcian blue stains and contain basement membrane components. 4 The epithelial cells are usually positive for carcinoembryonic and epithelial membrane antigens while duct-lining cells are positive for cluster of differentiation 117 and tumour protein 63. Alterations in chromosomes 6q, 9p and 17p12-13 are the most frequent cytogenetic alterations reported.…”

“…Alterations in chromosomes 6q, 9p and 17p12-13 are the most frequent cytogenetic alterations reported. 4 Although the histologic appearance of ADCC is well-described with certain features that may predict prognosis, surgical removal is often difficult given the infiltrative nature of these neoplasms with their propensity to invade into the adjacent tissues and extend along nerve segments. 5 This is further compounded by the deceptively circumscribed macroscopic appearance of the tumours.…”