Adenoid Cystic Carcinoma of Submandibular Salivary Gland With Late Metastases to Lung and Choroid: A Case Report and Literature Review

Cai, Qian; Zhang, Ruiguang; Wu, Gang; Dong, Xiaorong

doi:10.1016/j.joms.2014.04.011

Cited by 12 publications

(11 citation statements)

References 31 publications

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“…Much of the existing literature consists of small case series and reports from single-and multicenter studies, with limited large-population data. 4,14,15,[18][19][20][21][22][23][24] A previous SEER database analysis on submandibular gland cancer was performed in 2004 on data from 370 patients who received a diagnosis from 1988 through 1998. 2 Our study expands on the previous SEER database analysis through increasing the sample size, analyzing DSS, and performing statistical analysis on patient populations stratified by histologic subtype, stage, and tumor size.…”

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confidence: 99%

Epidemiology, Prognostic Factors, and Treatment of Malignant Submandibular Gland Tumors

Lee

Tan

Tong

et al. 2015

JAMA Otolaryngol Head Neck Surg

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We report, to our knowledge, the largest study to date focused on correlates of survival in submandibular gland malignant neoplasms. Multivariate analysis found that older age at diagnosis, high tumor grade, and later stage at presentation were correlated with decreased survival whereas female sex and surgical resection were correlated with increased survival. In addition, a 3-cm tumor cutoff size was demonstrated above which was associated with a significantly less favorable prognosis. Radiation therapy had mixed association with survival, dependent on tumor size and subtype.

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mentioning

confidence: 99%

Epidemiology, Prognostic Factors, and Treatment of Malignant Submandibular Gland Tumors

Lee

Tan

Tong

et al. 2015

JAMA Otolaryngol Head Neck Surg

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“…AdCC is an unpredictable and aggressive tumor with poor prognosis and high mortality rate 8 . Metastasis to cervical lymph nodes, lung, liver, brain, bone, skin, pituitary gland, sternum and choroid has been reported 7,9‐12 …”

Section: Discussionmentioning

confidence: 99%

Adenoid cystic carcinoma of the salivary gland metastasizing to the pericardium and diaphragm: Report of a rare case

Nasir

Monroe

Hagerty

et al. 2020

Diagnostic Cytopathology

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Background Adenoid cystic carcinoma (AdCC) is an uncommon malignancy of the salivary gland characterized by slow growth, increased risk of recurrence and poor prognosis. The annual incidence in the United States is approximately 1200 cases per year and rarely involves the body cavities. Case presentation We present a case of a 48‐year‐old male diagnosed with AdCC of the left submandibular gland. He received his last chemotherapy in 2006 and presented with pleural metastasis. After undergoing pleurectomy and decortication procedure, pericardial fluid and biopsies from the chest wall, sixth rib, diaphragm, pleural cavity and pericardium were sent for pathologic evaluation. A diagnosis of metastatic adenoid cystic carcinoma was confirmed, including in the pericardium, pericardial fluid and diaphragm. Conclusion AdCC of the submandibular gland is a malignant tumor with a high mortality rate. It is very rare for AdCC to metastasize to the pericardium and diaphragm. Metastasis to uncommon sites such as seen in our case with metastases to the pericardium and diaphragm shows the aggressive and unpredictable nature of this tumor, requiring close follow up, and indicating the need for molecular profile analysis and biomarker‐stratified clinical trials.

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“…At present, only 9 case reports of uveal metastasis from major salivary glands have been published, including 7 cases originating from the submandibular gland and 2 from the parotid gland. [2][3][4][5][6][7][9][10][11] The parotid gland is the largest of the major salivary glands. Both cases of uveal metastasis originating from the parotid gland were ACCs.…”

Section: Discussionmentioning

confidence: 99%

“…14 Among the previously mentioned cases of choroidal metastasis from ACC, 4 were treated with EBRT without IVB and showed favorable clinical response. 2,[5][6][7] Our patient was treated with a single IVB followed by EBRT in combination with systemic chemotherapy. Four months later, ophthalmic examination revealed improved visual function, reduced tumor size, and complete resolution of the secondary exudative retinal detachment.…”

Section: Discussionmentioning

confidence: 99%

“…Among the few reported cases of choroidal metastases arising from the salivary glands, adenoid cystic carcinoma (ACC) of the submandibular gland is the most common cause. [2][3][4][5][6][7] Oncocytic carcinoma of the parotid gland is an extremely rare malignant neoplasm, 8 and to the best of our knowledge, an unknown cause of choroidal metastases. We report a case of presumed choroidal metastasis from an oncocytic carcinoma of the parotid gland.…”

Section: Introductionmentioning

confidence: 99%

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Presumed Choroidal Metastasis From Oncocytic Carcinoma of the Parotid Gland: A Case Report

Cruz-Iñigo

Souza

2019

Journal of VitreoRetinal Diseases

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Purpose: This article reports a case of presumed choroidal metastasis from an oncocytic carcinoma of the parotid gland. Methods: A 70-year-old man with history of an oncocytic carcinoma of the parotid gland presented owing to a 1-month history of progressive blurred central vision shortly after metastatic surveillance workup revealed liver, lung, and spine metastases. Fundus examination of the right eye showed a yellow choroidal mass surrounding the optic nerve and extending inferonasally, which is associated with subretinal fluid involving the foveal center. A-scan and B-scan ultrasonography were remarkable for a dome-shaped choroidal mass with medium-to-high internal reflectivity. Fluorescein angiography revealed pinpoint foci of hyperfluorescence over the choroidal lesion with late leakage. Magnetic resonance imaging of the brain showed evidence of metastatic disease to the cerebellum. While the patient underwent systemic chemotherapy, external beam radiotherapy was used to treat the eye. Results: Four months later, visual acuity improved, the tumor reduced in size, and the subretinal fluid resolved. Systemic workup disclosed no new metastases. Conclusion: Oncocytic carcinoma of the parotid gland is a rare and aggressive malignant neoplasm with frequent recurrences and distant metastases. The current case suggests that oncocytic carcinoma can metastasize to the choroid and, consequently, ocular metastasis surveillance is advised in these patients.

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Adenoid Cystic Carcinoma of Submandibular Salivary Gland With Late Metastases to Lung and Choroid: A Case Report and Literature Review

Cited by 12 publications

References 31 publications

Epidemiology, Prognostic Factors, and Treatment of Malignant Submandibular Gland Tumors

Epidemiology, Prognostic Factors, and Treatment of Malignant Submandibular Gland Tumors

Adenoid cystic carcinoma of the salivary gland metastasizing to the pericardium and diaphragm: Report of a rare case

Presumed Choroidal Metastasis From Oncocytic Carcinoma of the Parotid Gland: A Case Report

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