Adenoid Cystic Carcinoma of the Uterine Cervix with Malignant Stroma

Manhoff, Dion T.; Schiffman, Raymond; Haupt, Helen M.

doi:10.1097/00000478-199502000-00012

Cited by 13 publications

(4 citation statements)

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“…Immunohistochemical studies revealed that epithelial markers and vimentin are more diffuse and intense in the carcinomatous and sarcomatous components, respectively, although coexpression may be present. Immunoreactivity for a variety of muscle markers, including actin, desmin, myosin, and myoglobin, is almost invariably confined to the sarcomatous cells, many of them with nonspecific features and others with a rhabdomyoblastic appearance (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)15) .…”

Section: Discussionmentioning

confidence: 99%

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Malignant mixed Mullerian tumor of the uterine cervix with neuroendocrine differentiation

Ribeiro‐Silva¹,

Novello-Vilar²,

Cunha-Mercante³

et al. 2002

Int J Gynecol Cancer

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Malignant mixed Mullerian tumors (MMMTs) are rare neoplasms. We report the clinical, pathologic, and immunohistochemical features of an MMMT primary of uterine cervix. This lesion was composed of a poorly differentiated epithelial component (cytokeratin positive) and a spindle cell component (vimentin positive) with heterologous (myoblastic) differentiation (focal 1A4 positive). There were also cells with neuroendocrine features that expressed S-100 and chromogranin A. Along with a brief review of this amazing neoplasm, some histogenetic concepts relevant to this case are discussed. To our knowledge this is the first report of a malignant mixed Mullerian tumor of the uterine cervix with neuroendocrine differentiation.

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Section: Discussionmentioning

confidence: 99%

“…Their counterparts from the uterine cervix are even more rare. Only about 20 cases have been reported (2)(3)(4)(5)(6)(7)(8)(9)(10)(11) (Table 1). As an unusual finding, these neoplasms may show neural differentiation (12) .…”

mentioning

confidence: 99%

Malignant mixed Mullerian tumor of the uterine cervix with neuroendocrine differentiation

Ribeiro‐Silva¹,

Novello-Vilar²,

Cunha-Mercante³

et al. 2002

Int J Gynecol Cancer

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“…A swollen uterus was often palpated on pelvic examination. Some reports stated that CS are resistant to certain therapies, leading to a worse prognosis compared with usual epithelial and mesenchymal malignancies, being associated with early metastasis to other organs and intraperitoneal recurrence 16–25,32 . The severity of the disease at the start of therapy might influence the prognosis the most.…”

Section: Discussionmentioning

confidence: 99%

“…Among malignant uterine tumors, CS is rarely encountered, with a frequency of approximately 3%, 16 but major CS arise in the corpus. Uterine cervical CS that were documented in detail are limited to 24 cases, 17–25 but include the present case (Table 1). The patients were aged from 23 to 87 years, and 75% were aged >50 years.…”

Section: Introductionmentioning

confidence: 99%

Case of uterine cervical carcinosarcoma

Iida¹,

Yasuda²,

Kajiwara³

et al. 2005

J of Obstet and Gynaecol

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Carcinosarcoma (CS) is a rare neoplasm that is called a mixed epithelial and mesenchymal malignancy. CS of the uterine cervix is much less common than its counterparts in the uterine corpus. A 61-year-old, gravida 2, para 2 woman, who had undergone menopause 16 years prior to the presentation, was diagnosed with CS of the uterine cervix. A semiradical hysterectomy was carried out on the diagnosis of stage Ib1 cervical cancer. The patient underwent whole pelvic 45 Gy radiation as a postoperative additional treatment, but she died from multiple organ failure by metastasis 17 months after the operation. The tumor protruded from the cervix to the vagina and measured 4.5 x 3.0 cm. Histologically, the tumor was characterized as a squamous cell carcinoma and mesenchymal malignancy, represented by osteosarcomatous components. The stroma was largely composed of atypical spindle-shaped cells, which were immunohistochemically demonstrated to be of epithelial origin. Uterine cervical CS is one of the aggressive malignancies, and squamous cell carcinomas are common epithelial counterparts of cervical CS as well as adenocarcinomas.

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