Adenoid Cystic Carcinoma of the Breast

Torrão, Maria Manuel Mesquita; Costa, José Monteiro da; Ferreira, Eduardo; Silva, Mário Vieira da; Paiva, Irene Alves de; Lopes, Carlos

doi:10.1111/j.1524-4741.2007.00406.x

Cited by 4 publications

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“…Supporting findings in previous reports [15,17-21,27,29,31,35-38,48,50,52,54-57], the majority of breast-ACC in the SEER Program was ER-negative/PR-negative; however, hormone receptor-positive tumors have also been described in a minority of cases [22,23,25,32,34,42,58]. Although information on HER-2-neu is not available in the SEER Program, other series have uniformly reported HER-2-neu-negative status in breast-ACC [18,20,21,23,31,34,37,38,42,50,52,55,56].…”

Section: Discussionsupporting

confidence: 91%

Adenoid cystic carcinoma of the breast in the United States (1977 to 2006): a population-based cohort study

et al. 2010

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IntroductionAdenoid cystic carcinoma of the breast (breast-ACC) is a rare and special type of basal-like tumor for which scant population-based descriptive data exist. We sought to provide new population-based information on breast-ACC incidence, relative survival, and associated cancer risk in the United States.MethodsUsing data from the Surveillance, Epidemiology and End Results Program, we calculated age-adjusted incidence rates (IRs), IR ratios (IRRs), and relative survival for breast-ACC, and standardized incidence ratios (SIRs) for other cancers.ResultsOverall 338 women (IR = 0.92/1 million person-years) were diagnosed with breast-ACC during 1977 to 2006. Blacks had 39% lower IRs than Whites (IRR = 0.61, 95% confidence interval = 0.37 to 0.96), and IRs remained constant over the 30-year period. Ninety-five percent of cases presented with localized stage (n = 320; IR = 0.87), and the highest IRs were observed for estrogen receptor (ER)-negative/progesterone receptor (PR)-negative tumors (IR = 0.56). Like other typically ER-negative tumors, age-specific IRs increased until midlife and then plateaued. Five-year, 10-year, and 15-year relative survival was 98.1%, 94.9%, and 91.4%, respectively. The risk of female breast cancer was not increased following (SIR = 0.89, 95% confidence interval = 0.43 to 1.64) or preceding (SIR = 0.71, 95% confidence interval = 0.28 to 1.46) breast-ACC. Similarly, no association was observed for breast-ACC and risk of all other cancers combined, solid tumors, or lymphohematopoietic malignancies.ConclusionsBreast-ACC among women is characterized by ER-negative/PR-negative expression, rare regional lymph node involvement, a favorable prognosis with excellent survival, and absence of associated cancers. These findings reinforce the importance of tailored treatments for breast-ACC and lend credence to the apparent heterogeneity of basal-like breast cancers.

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Section: Discussionsupporting

confidence: 91%

Adenoid cystic carcinoma of the breast in the United States (1977 to 2006): a population-based cohort study

et al. 2010

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“…Adenoid cystic carcinoma has had various growth patterns described: glandular, tubular and solid. The characteristic histologic pattern that includes small basaloid cells with a solid cribiform pattern or tubular growth patterns enclosing pseudoglandular spaces with minimal eosinophilic material is noted on fine needle aspiration (5). Ro et al.…”

Section: Discussionmentioning

confidence: 99%

“…Histologically ACC of the breast is characterized by small basaloid cells with a solid cribiform pattern or tubular growth patterns enclosing pseudoglandular spaces with minimal eosinophilic material (5). ACC has been seen in multiple areas of the body including the breast, vulva, skin, salivary glands, lacrimal glands, and the upper respiratory tract (6).…”

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confidence: 99%

Adenoid Cystic Breast Carcinoma: Is Axillary Staging Necessary in All Cases? Results from the California Cancer Registry

et al. 2011

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Introduction Adenoid cystic carcinoma is an uncommon type of breast cancer. There are limited data about its epidemiology, tumor characteristics, and outcomes. Using a large, population-based database, this study aims to identify specific characteristics of patients with adenoid cystic breast cancer, investigate its natural history, and determine its long-term prognosis. Methods The California Cancer Registry (CCR), a population-based registry, was reviewed from the years 1988 to 2006. The data were analyzed with relation to patient age, tumor size and stage, and overall survival. Relative cumulative actuarial survival was determined using the Berkson-Gage life table method. Results A total of 244 cases of invasive adenoid cystic cancer were identified in women during this time period. The patients’ median age was 61.9 years. Most cases were diagnosed in non-Hispanic White women (82%, n=200), followed by African-American (6%, n=15), Asian/Pacific-Islander (5.7%, n=14) and Hispanic women (4.4%, n=12). The remainder of the patients was of unknown or other ethnicity. Tumors were between 1 and 140 mm in size. At the time of diagnosis, 92% (n=225) of patients had localized disease, 5% (n=12) of patients had regional disease, and even fewer (n=7) had either distant or unknown staged disease. Lymph node involvement was not present in any tumors smaller than 1.4 cm. The relative cumulative survival of patients with adenoid cystic breast carcinoma was 95.6% at 5 years and 94.9% at 10 years. Conclusion Adenoid cystic carcinoma of the breast is a rare disease with an overall good prognosis. Knowing that this cancer usually presents as localized disease, with lymph node involvement seen only with larger tumors, can help clinicians plan the operative management of these tumors.

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“…The typical clinical feature is a single mass of the breast, and multiple nodules are rare. Most ACCs are located under the areola or in the upper outer quadrants (4,8,9). ACC of the breast has no characteristic imaging findings.…”

Section: Introductionmentioning

confidence: 99%

Management of Adenoid Cystic Carcinoma of the Breast: A Single-Institution Study

et al. 2021

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ObjectiveThe purpose of our study was to analyze the clinicopathologic features and surgical and oncological outcomes of adenoid cystic carcinoma (ACC) of the breast and to provide the basis for a clinical therapeutic schedule.MethodsA total of 14 patients with primary breast adenoid cystic carcinoma treated at Cancer Hospital of the Chinese Academy of Medical Sciences from January 2000 to December 2017 were included. Data on clinical presentation, treatment strategy, and outcome, as well as the pathological features of ACC, were reviewed and analyzed.ResultsFourteen patients were diagnosed with ACC of the breast, out of 23205 total patients treated for breast cancer (0.06%). All but three patients were postmenopausal, with a median age at diagnosis of 60.5 years (range, 39–73 years). The most common clinical presentation was a palpable mass (85.7%), and the imaging characteristics of all patients on color Doppler ultrasound and mammography were nonspecific. Six patients (42.9%) were suspected of having ACC by fine-needle aspiration cytology (FNAC) and were confirmed by postoperative histology and immunohistochemistry. All 14 patients underwent surgery, and no patient had a positive lymph node status. Median tumor size was 1.75 cm (range, 1–3 cm). Eight/14 (57.1%) patients were hormone receptor negative (HR−) and HER-2/neu (−) (HER2−). The remaining patients were hormone receptor positive (HR+). There was no significant difference in clinicopathological characteristics between the HR+ group and the HR- group (P>0.05). The mean follow-up period was 57 months. Local recurrence occurred in 14.3% of patients, 1.7% of patients had distant metastasis, all patients with local recurrence or distant metastasis were in the HR (-) group, and all patients were alive at the last follow-up.ConclusionACC of the breast cannot be simply summarized as triple-negative breast cancer because it also includes a small number of hormone receptor-positive breast cancers. Establishing a preoperative diagnosis is difficult on the basis of clinical imaging examination, FNAC may be useful tool in the diagnosis. the final diagnosis can only be assessed based on the results of the histopathological and immunohistochemical examination. Breast-conserving surgery may be an alternative treatment strategy, and axillary lymph node dissection or sentinel node biopsy may not be necessary in some cases.

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Adenoid Cystic Carcinoma of the Breast

Cited by 4 publications

References 0 publications

Adenoid cystic carcinoma of the breast in the United States (1977 to 2006): a population-based cohort study

Adenoid cystic carcinoma of the breast in the United States (1977 to 2006): a population-based cohort study

Adenoid Cystic Breast Carcinoma: Is Axillary Staging Necessary in All Cases? Results from the California Cancer Registry

Management of Adenoid Cystic Carcinoma of the Breast: A Single-Institution Study

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