Adenoid cystic carcinoma of the parotid metastasising to the dura fifteen years post primary resection: A case report

Bozkurt, Gülpembe

doi:10.14744/nci.2019.12844

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…Other clinical features which have been linked to SACC of the submandibular gland include hyposalivation due to sublingual gland obstruction [ 14 ] and first bite syndrome, a sequela of parapharyngeal space surgery historically linked to the denervation of the parotid gland, not the submandibular [ 15 ]. Other clinical features which are frequently associated with SACC include dull pain, altered sensation of the tongue, palate maxilla or face, and/or facial nerve palsy [ 16 ], indicating perineural invasion (PNI) of the local nerves, a sign mainly encountered in the advanced stages of the disease [ 1 , 17 ]. Furthermore, some reports have interestingly linked SACC to ectopic Cushing syndrome.…”

Section: Resultsmentioning

confidence: 99%

Adenoid Cystic Carcinoma of Salivary Glands: A Ten-Year Review and an Assessment of the Current Management, Surgery, Radiotherapy, and Chemotherapy

Saleh

Ukwas

2023

International Journal of Otolaryngology

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Adenoid cystic carcinoma (ACC) is a rare cancer that arises from the salivary glands and other sites in the body, such as the lung and breast. Although the tumor accounts for 10% of all salivary gland malignancies, it only accounts for 1% of head and neck malignancies. It can affect both major and minor salivary glands; here, it is called salivary gland adenoid cystic carcinoma or SACC, with a slight predilection to the latter, and commonly manifests between the 6th and 7th decades of life. The disease also shows a slight female predilection, with a reported female to male ratio of 3 : 2. Lesions of SACC are often insidious and slow-growing, and symptoms such as pain and altered sensation are frequently associated with advanced stages of the disease. Salivary adenoid cystic carcinoma is characterized by perineural invasion (PNI), a distinctive feature that potentially plays a significant role in the tumor’s relapse and recurrence, which is approximately 50%. The disease is not prevalent, and its etiopathogenesis is poorly understood, although several genetic patterns and biomarkers have been linked to its initiation and/or progression. The discovery of these mutations and biomarkers has encouraged several clinical studies to use therapeutic agents to target the specific receptors on the cancer cells to potentially prevent further proliferation of the tumor cells and metastasis of the disease. Diagnosis of SACC is often challenging and frequently requires a combination of clinical examination, imaging, and histopathology. Management of SACC is primarily surgical excision, while radiotherapy has shown to be effective in improving local control in cases with microscopic residual disease. However, treatment of recurrent or metastatic tumors by radiotherapy with or without chemotherapy has so far shown limited success. The aim of this thesis is to provide an update of literature on SACC with a particular focus on the latest management approaches and future trends.

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