Adenoid cystic carcinoma of the lacrimal sac: case report

Ramos, Antonio; Pozo, Carmen Del; Chinchurreta, Ana; Garcia, Fernando U.; Lorenzo, Mercedes; Gismero, Saturnino

doi:10.5935/0004-2749.20160095

Cited by 17 publications

(11 citation statements)

References 10 publications

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“…The most appropriate management of lacrimal sac tumors depends more on tumor size and the general condition of the patient. Exenteration does not ensure a better prognosis and causes substantial facial disfigurement which may cause tremendous physiological and psychological trauma to the patients . In our study, only 37.2% of the patients (19/51) selected extended resection, two underwent orbital exenteration, and 56.9% of cases (29/51) received conservative resection, which was different from traditional management.…”

Section: Discussionmentioning

confidence: 56%

“…Exenteration does not ensure a better prognosis and causes substantial facial disfigurement which may cause tremendous physiological and psychological trauma to the patients. 14,15 In our study, only 37.2% of the patients (19/51) selected extended resection, two underwent orbital exenteration, and 56.9% of cases (29/51) received conservative resection, which was different from traditional management. One possible reason may be that radiotherapy has played an extremely important role in the treatment of lacrimal sac SCC.…”

Section: Discussionmentioning

confidence: 66%

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Clinical management and outcomes of lacrimal sac squamous cell carcinoma

Song¹,

Wang²,

Wang

et al. 2019

Head & Neck

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Background To investigate the management and outcomes of patients with lacrimal sac squamous cell carcinoma (SCC). Methods This retrospective study examined 69 lacrimal sac SCC cases treated at our hospital between 1992 and 2017. The potential risk factors for prognosis, a new staging method, treatment outcomes, and complications were investigated. Results The 5‐year overall survival (OS) and progression‐free survival (PFS) were 87.6 ± 4.8% and 76.3 ± 6.4%, respectively. Positive lymph node was associated with worse OS and PFS. We divided lacrimal sac SCC into four clinical stages, with significant differences in OS (P = .026) and PFS (P = .042) among each stage. Definitive radiotherapy was equivalent to surgery plus radiotherapy in 26.1% (18/69) of cases, and the incidence of complications was not higher. Conclusions Lymph node status was a key factor in determining outcomes. Our staging method could effectively classify tumor stage and predict prognosis, which can contribute to optimizing treatment regimes. Radiotherapy played an important role in treatment.

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 66%

Clinical management and outcomes of lacrimal sac squamous cell carcinoma

Song¹,

Wang²,

Wang

et al. 2019

Head & Neck

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“…He was diagnosed and treated as chronic dacryocystitis at the local hospital, but the symptoms were not improved. Therefore, we need to be alert to the possibility of malignant lacrimal sac tumors in patients with chronic dacryocystitis who had poor respond to standard treatments (11).…”

Section: Discussionmentioning

confidence: 99%

“…Complete excision of the tumor and lacrimal drainage system followed by radiotherapy with or without adjuvant chemotherapy was still the main treatment for ACC of the orbit (16)(17)(18). However, there are also argues that surgery in this area often involves orbital exenteration that would substantially impair the quality of life and raise psychological and psychiatric disorders in patients (11,19), while the prognosis might not necessary be improved (20). Therefore, extensive surgery should be carefully evaluated for patients with ACC of the lacrimal sac, especially in young patients such as that in the present case.…”

Section: Discussionmentioning

confidence: 99%

Successful management of adenoid cystic carcinoma of the lacrimal sac with apatinib combined with concurrent chemoradiotherapy: a case report

Zhang

Liu

et al. 2021

Ann Palliat Med

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Adenoid cystic carcinoma (ACC) of the lacrimal sac is an extremely rare disease with a poor prognosis. There is currently no standard treatment for this malignancy. Radical surgical excision followed by radiotherapy and chemotherapy is the preferred treatment for localized ACC of the lacrimal sac. Apatinib has shown efficacy in recurrent/metastatic ACC. The role of apatinib in combination with concurrent chemoradiotherapy in patients with non-operated localized advanced ACC is not clear. Here, we report a 30-year-old man with a 1-year history of epiphora of the left eye and nasal congestion who was diagnosed as ACC of the lacrimal sac. The computed tomography (CT) scan showed the tumor invading the left orbit and left maxillary sinus. He refused surgical resection and instead received combined apatinib and nedaplatinbased concurrent chemoradiotherapy. He experienced moderate adverse effects such as nausea, hypertension, myelosuppression that were well controlled after symptomatic supportive care. Complete response was observed 3 weeks following the treatment. The patient remained free of disease until the last follow up by December 2020, 22 months after the treatment. This case suggested that combined apatinib and concurrent chemoradiotherapy might be an option for locally advanced ACC patients who are ineligible for or rejective to surgical resection.

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“…The case was a 41-year-old woman with late diagnosis, who underwent ophthalmological examination and multidisciplinary treatment, and was finally confirmed as primary ACC. [13] The ACC also occurred in the female reproductive system. For instance, a 23-year-old woman was diagnosed ACC in left ovary, the tumor had the typical cribriform pattern of ACC, lacked any component of surface epithelial carcinoma, and showed myoepithelial differentiation.…”

Section: Discussionmentioning

confidence: 99%

Adenoid cystic carcinoma of the vagina

Zhang

Huang

et al. 2019

Medicine

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Rationale:Squamous carcinoma is the most common malignancy of vagina. Adenoid cystic carcinoma (ACC) in the vagina is very rare.Patient concerns:In the present study, we present a 45-year-old woman with a palpable swelling in the vagina. The patient reported body paresthesia, chest congestion, expiratory dyspnea, and itching in the thigh root.Diagnosis:The ultrasound results revealed inhomogeneous echoes of the muscular layer in the middle and distal of the vagina, and probed a slightly richer blood flow signal. Then biopsy was performed. On microscopic examination, it was observed that tumor cells were arranged in a tubular or cribriform pattern, and exhibited a consistent size, small nuclei, and nuclear fission. The myoepithelium was lined around the glandular cavity, but the myoepithelium was tumorous. Immunohistochemistry was performed for further verification. Vimentin was positive in mesenchyme and CK-P was positive in epithelial cells. P63 and calponin were spotted, which were focal positive around the glandular cavity. Finally, the patient was diagnosed as ACC.Interventions:At last, the patient chose chemoradiotherapy, not surgical excision.Outcomes:The patient is alive and well 13 months after the initial diagnosis.Lessons:ACC in the vagina is extremely rare. To our knowledge, this report is the first case of ACC arising from the vagina in English-language literature. Extensive surgical section of the tumour and chemoradiotherapy are recommended for therapy. Because of rarity, the prognosis of ACC in vagina is not known.

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Adenoid cystic carcinoma of the lacrimal sac: case report

Cited by 17 publications

References 10 publications

Clinical management and outcomes of lacrimal sac squamous cell carcinoma

Clinical management and outcomes of lacrimal sac squamous cell carcinoma

Successful management of adenoid cystic carcinoma of the lacrimal sac with apatinib combined with concurrent chemoradiotherapy: a case report

Adenoid cystic carcinoma of the vagina

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