Adenoid Cystic Carcinoma of the Trachea Treated with PET-CT Based Intensity Modulated Radiotherapy

Haresh, K.P.; Prabhakar, R; Rath, Goura Kishore; Sharma, Daya Nand; Julka, Pramod Kumar; Subramani, V.

doi:10.1097/jto.0b013e31817c9245

Cited by 28 publications

(22 citation statements)

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“…The function of radiotherapy in patients with ACC has been evaluated in several studies (25–27), with varying results, and its role remains uncertain. Neutron beam radiotherapy may be used for adjuvant therapy (28).…”

Section: Discussionmentioning

confidence: 99%

“…In selected cases, the administered dose must be provided as five 2-Gy fractions per week over six weeks, with a total dose of 60–70 Gy. Intensity-modulated radiation therapy (IMRT) (29) or positron emission tomography CT-directed IMRT (27) may be employed rather than standard procedures. However, in contrast to SCC patients, studies have shown that ACC patients with node involvement who underwent complete resection may not receive any benefits from this treatment modality (23,30).…”

Section: Discussionmentioning

confidence: 99%

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Tracheal adenoid cystic carcinoma mimicking a thyroid tumor: A case report

et al. 2014

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At present, only eight cases of tracheal adenoid cystic carcinomas (ACCs) mimicking thyroid tumors have been reported. Since there are no guidelines available regarding their diagnosis and treatment, they present a significant clinical challenge. In the present study, patient treatment was analyzed to deliver the first concise summary of treatment options in patients with ACC mimicking a thyroid tumor. In addition, all available data regarding molecular abnormalities of this disease have been discussed. The current study presents a case of a 17-year-old patient with a tracheal ACC mimicking a thyroid tumor. The patient was diagnosed in 2007 with a pathological mass between the left lobe of the thyroid and the trachea, and underwent surgery and radiotherapy. In 2010, multiple lesions in the lungs were diagnosed and pulmonary metastasectomy was performed. Following surgery, the patient has been disease-free for almost 30 months. Thyroid tumor biopsy may reveal ACCs. This pathological report requires further investigation of the head and neck in order to confirm if the disease is of tracheal origin. Patients may present with a neck swelling, hoarseness of voice or dysphagia. Surgery must be considered as first-line therapy for all patients with local disease as it may be curative. For palliative treatment chemoradiotherapy based on cisplatin may be effective. The identification of cytogenetics, tumor suppressor genes, oncogenes, epigenetic alterations and mitochondrial abnormalities specific for ACCs is critical to the development of targeted therapies. Thus far, large studies have only reported the transcriptional activator Myb and mammalian target of rapamycin signaling pathway to be disrupted in ACCs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Tracheal adenoid cystic carcinoma mimicking a thyroid tumor: A case report

et al. 2014

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“…Radiotherapy should be planned on the basis of conformal techniques, preferably with the use of IMRT (10). A previous study has proposed the possibility of combining teleradiotherapy with brachytherapy, boosting the radiotherapeutic dose to macroscopic disease areas and therefore limiting undesirable effects in adjacent critical tissues and organs (10,11). Radiotherapy is shifting towards the use of proton therapies (12).…”

Section: Discussionmentioning

confidence: 99%

“…Metastasis into lymph nodes and a non-radical surgical procedure are obligatory indications for the use of postoperative radiotherapy (3,13). A dose for the treatment of the microscopic disease should be at least 60 Gy in fractions of 2 Gy administered five times a week (3,11). A higher dose should be given to residual disease areas and to surgical sites following non-radical surgery (10).…”

Section: Discussionmentioning

confidence: 99%

Recurrence of adenoid cystic carcinoma of the trachea treated with radical radiotherapy: A case report

2018

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Abstract. Adenoid cystic carcinoma (ACC) of the trachea is a relatively rare tumor among thoracic diseases. The present study reports the case of a 23-year-old woman with ACC of the trachea who underwent surgical resection of the tumor in The National Institute of Tuberculosis and Lung Diseases (Warsaw, Poland). Histopathological examination revealed that the tumor was not completely resected (R2 resection) and strict observation of the patient was therefore prescribed. After ~9 years of follow-up, clinical and histopathological tumor progression was confirmed and the patient was referred to the Centre of Oncology in Warsaw. The localization and advanced nature of the disease precluded surgical intervention, and radical radiotherapy was therefore performed using intensity-modulated radiation therapy. A total dose of 7,590 Gy, the planning target volume, was administered. A hyperfractionation scheme of radiotherapy was used: 2 fractions of 1.15 Gy daily, with at least a 6 h break in between. Tumor regression was observed following treatment and has been maintained for >3 years, assessed by clinical and computed tomography and positron emission tomography imaging examinations.

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“…However, in a PubMed search of key words (choroidal, melanoma, PET, PET/CT, positron, emission, tomography, computed, radiation, control, and SUV), we could find no reports of the use of PET/CT in the assessment of choroidal melanoma control. Despite this finding, PET/CT SUV has been used to evaluate other cancers after chemotherapy and irradiation (1,2,6,15,(26)(27)(28)(29)(30)(31)(32).…”

Section: Introductionmentioning

confidence: 98%