Adenoid cystic carcinoma of the breast

Thomas, Devon N; Asarian, Armand; Xiao, Philip

doi:10.1093/jscr/rjy355

Cited by 21 publications

(25 citation statements)

References 8 publications

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“…Discussion of primary ACC of the breast has been limited by the number of cases as it accounts for only 0.1-1% of breast cancers [ 1 ]. It typically presents as a painful or painless sub-areolar mass, although it has also been described as an asymptomatic finding on screening mammogram [ 3 , 5 ]. Following the recognition of irregular densities or masses on mammogram, a core needle biopsy will confirm the diagnosis [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…It typically presents as a painful or painless sub-areolar mass, although it has also been described as an asymptomatic finding on screening mammogram [ 3 , 5 ]. Following the recognition of irregular densities or masses on mammogram, a core needle biopsy will confirm the diagnosis [ 5 ]. The histology of breast ACC resembles salivary ACC and consists of a biphasic pattern of myoepithelial and epithelial cells arranged in several architectural patterns [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

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Adenoid cystic carcinoma of the breast with distant metastasis to the liver and spleen: a case report

Gillie

Kmeid

Asarian

et al. 2020

Journal of Surgical Case Reports

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Adenoid cystic carcinoma (ACC) of the breast is a rare malignancy, accounting for 0.1–1% of breast cancers. Histologically breast ACC is similar to ACC’s found in salivary tissue and is a triple-negative breast cancer with an uncharacteristically favorable prognosis and low incidence of metastasis. Most cases present as a painful, palpable mass; however, asymptomatic cases found on screening mammograms have also been noted. Core needle biopsy or excisional biopsy is necessary for definitive diagnosis of breast ACC. Immunohistochemistry of these cancers can differentiate breast ACC from masses with similar histology, such as invasive cribriform carcinoma and collagenous spherulosis. There is no well-established treatment guideline for ACC; however, it has been noted that reoccurrence and metastasis are noted more in cases of local resection than mastectomy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Adenoid cystic carcinoma of the breast with distant metastasis to the liver and spleen: a case report

Gillie

Kmeid

Asarian

et al. 2020

Journal of Surgical Case Reports

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“…Adenoid Cystic Carcinoma of the Breast (ACCB) is a rare subtype, representing <0.1% of all breast cancer diagnosed [1]. ACCB usually affects women, in whom it is more frequent in the sixth decade of life [2].…”

Section: Aimmentioning

confidence: 99%

“…Histologically presentation shows a double component both luminal epithelial and basal myoepithelial cells, without oestrogen, progesterone and Her-2 receptor expression [3,4]. Despite its belonging to triplenegative class breast tumor, clinical presentation of this disease is usually isolated to breast gland, in 2% of pts patients (pts) there is a nodal involvement and rarely it can metastasize in other parenchyma [1,2,5,6]. This is due to downregulation of genes involved in migration, proliferation and the immune response [7].…”

Section: Aimmentioning

confidence: 99%

The role of radiotherapy (RT) in the treatment of Adenoid Cystic Carcinoma of the Breast: case report of RT retreatment and literature review

Smaniotto¹,

Terribile²,

Marazzi³

et al. 2019

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This study reviews the recent literature on the role of definitive radiotherapy (RT) in the management of adenoid cystic carcinoma of the breast (ACCB) and presents comprehensive data on clinical outcomes. A case report of radiotherapy retreatment in ACCB is reported for first time in literature. Methods: The authors performed a literature review using PubMed (1981-2019) to identify all studies that match with keywords. Inclusion criteria were articles reporting patients underwent radiotherapy after ACCB diagnosis with follow up reporting. Data analyzed were number of pts, age, study design, multimodality treatment management with radiotherapy schedule, stage of disease, pathological risk factors, local relapse free survival (LFRS), metastases free survival (MFS) and overall survival (OS). Results: Of the 60 identified studies, 15 met the inclusion criteria. All studies had a retrospective design. Overall, 967 patients (median, 64; range, 1-478) were included. A high heterogeneity was found across studies in terms of pathological features available, local approach in multimodality management, adjuvant RT administration, and reported outcomes. Mean LRFS reported by case reports was 24 months (range 20-48). Mean DFS reported by case series and retrospective series was 87.9% (range 69-100%). Mean OS reported in case reports was 30 months (range 12-84). Mean 5-years OS reported in retrospective series was 89.7%. Mean 10-years OS reported in retrospective series was 78.7%. In some retrospective series radiotherapy was found significantly related to local control (p=0.03) and with an absolute survival benefit of 9% at 5 year and of 21% at 10 years (p=0.005). Conclusion and implications for practice: To our knowledge this is the first report on radiotherapy retreatment in ACCB local relapse. This study also reviews the recent literature on the role of adjuvant RT in the management of ACCB and presents comprehensive data on long-term clinical outcome. Some significant results about RT are improvement in local control and survival benefit also since at 10 years in some series. Further studies are needed to confirm these results.

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“…ACC accounts for 0.1–1% of all breast cancers [ 4 , 5 ]. The major issue in the management is, due to its rarity, the absence of clinical trials enrolling these patients to determine the best treatment plan.…”

Section: Introductionmentioning

confidence: 99%

Adenoid cystic carcinoma of the breast - Discordant size on imaging and pathology: A case report and review of literature

Agafonoff

Sobolewski

Braverman

2019

Annals of Medicine and Surgery

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Introduction Adenoid cystic carcinoma (ACC) is an uncommon tumour of the breast. It is known for its rare lymph node involvement and distant metastasis. A triple-negative breast cancer that has a favorable prognosis compared to other triple negative ductal carcinomas, it accounts for approximately 0.1–1% of all breast cancers. Presentation of case We report a case of a 69-year-old female with a palpable left breast mass who underwent multiple imaging modalities with significant size variance between the studies. Breast conserving therapy (BCT) was performed with axillary sentinel lymph node biopsy (SLNB) followed by radiation therapy (RT). Pathological examination confirmed the tumour as ACC. Discussion ACC, known as an persistent if low-grade malignant tumour of salivary gland, is considered to have low-malignant potential in the breast. It is a very rare subtype and from this scant data, there is minimal mention about size discrepancy between imaging modalities such as ultrasound and MRI. No consistent MRI features have been demonstrated, with the exception of T2 hyperintensity in larger lesions and T2 iso-intensity in smaller lesions. Ultrasound demonstrates primarily a hypoechoic or heterogenous mass with minimum vascularity, consistent with our radiographic findings. Conclusion ACC is a rare entity in breast cancer pathology. Its size can be highly variable as measured by various radiographic modalities, and final Pathology from the surgical specimen is, as always, required for an accurate tumoral diameter. With that caveat, careful utilization of pre-operative imaging modalities is critical in pre-surgical planning to choose the appropriate surgery.

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Adenoid cystic carcinoma of the breast

Cited by 21 publications

References 8 publications

Adenoid cystic carcinoma of the breast with distant metastasis to the liver and spleen: a case report

Adenoid cystic carcinoma of the breast with distant metastasis to the liver and spleen: a case report

The role of radiotherapy (RT) in the treatment of Adenoid Cystic Carcinoma of the Breast: case report of RT retreatment and literature review

Adenoid cystic carcinoma of the breast - Discordant size on imaging and pathology: A case report and review of literature

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