1999
DOI: 10.1055/s-2008-1058137
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Adenoid Cystic Carcinoma of the Skull Base

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Cited by 26 publications
(35 citation statements)
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“…When the skull base was affected, overall survival is much shorter and more patients died with disease (p = 0.005): 26 patient had skull base involvement, surviving an average of 6.5 years and 80.8 % dead of disease versus patients without skull base involvement having an average survival of 12.1 years and 41.7 % dead of disease. These findings are similar to other reviews [6,52,84].…”
Section: Treatmentsupporting
confidence: 93%
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“…When the skull base was affected, overall survival is much shorter and more patients died with disease (p = 0.005): 26 patient had skull base involvement, surviving an average of 6.5 years and 80.8 % dead of disease versus patients without skull base involvement having an average survival of 12.1 years and 41.7 % dead of disease. These findings are similar to other reviews [6,52,84].…”
Section: Treatmentsupporting
confidence: 93%
“…p16 overexpression was seen in all of our cases (luminal nuclear and cytoplasmic reaction; stronger cytoplasmic reaction than in those cases that had associated pleomorphic adenoma), but does not necessarily imply biologically integrated HPV as a potential etiology, as it does with oropharyngeal carcinoma [12]. None of the cases tested contained high-risk HPV (which includes 16,18,31,33,35,39,45,51,52,56,58, and 66) by in situ hybridization, different from a recent series reporting the presence of HPV 33 specifically [141].…”
Section: Immunohistochemical Studiesmentioning
confidence: 59%
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“…Another key advance in the treatment of ACC has been the recognition of perineural extension as a harbinger of poor outcome. 7,13,16,18,20,23,24,31 As such, our strategy has been to maximally resect all perineural disease until negative margins are obtained or the risk of neurological complications (via carotid injury) precludes further resection. 13,46,47 Finally, the importance of bony resection cannot be underestimated, as ACC involving the lacrimal gland is best treated with orbitectomy rather than local resection.…”
Section: Discussionmentioning
confidence: 99%