Adenoid cystic carcinoma of the minor salivary glands

Busuttil, A.

doi:10.1017/s002221510008333x

Cited by 20 publications

(14 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The details of clinical presentation are summarized in Table II. The majority of patients presented with either sinonasal symptoms (14), cranial neuropathy (13), or otological findings (11). Less commonly, patients had ophthalmological manifestations (5).…”

Section: Resultsmentioning

confidence: 99%

“…A review of the English literature yielded a total of 98 cases, of which 93 were adenoid cystic carcinoma and the remainder were mucoepidermoid carcinoma. 3–27 However, the vast majority of these reports consist of isolated cases or small series with sparse information and from which little can be concluded regarding the definitive management of this difficult clinical problem.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Management of Nasopharyngeal Salivary Gland Malignancy

Schramm

Imola

2001

The Laryngoscope

View full text Add to dashboard Cite

Planned combined surgery and radiation therapy achieves survival outcomes and recurrence rates in nasopharyngeal salivary gland malignancy comparable to results reported using the same treatment for minor salivary gland tumors cancer originating elsewhere in the head and neck. Because of the high rate of occult neck metastases, we recommend elective neck dissection as part of the surgical treatment with this disease entity. The lateral infratemporal middle fossa approach provides safe and adequate access to resect the vast majority of these tumors with acceptable complication rates. A reliable form of vascularized reconstruction is necessary to prevent serious postoperative complications, and we currently prefer the gastro-omental free flap.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Management of Nasopharyngeal Salivary Gland Malignancy

Schramm

Imola

2001

The Laryngoscope

View full text Add to dashboard Cite

show abstract

“…The pseudocysts are surrounded by tumour cells of the myoepithelial type and are filled with extracellular matrix components including basement membrane molecules [1][2][3][4][5]. Since there are few cellular components in the pseudocystic space, it has been postulated that these tumour cells secrete extracellular matrix components into the intercellular space [6][7][8][9]. The abundant retention of basement membrane molecules in the stromal space and pseudocystic cavities suggests that basement membranerich matrix is essential for proliferation of adenoid cystic carcinoma cells, and we have interpreted their frequent invasion of peripheral nerves, blood vessels, and skeletal muscles as showing that these carcinoma cells have an affinity to basement membranes [8].…”

Section: Introductionmentioning

confidence: 99%

Intracellular transport of basement membrane-type heparan sulphate proteoglycan in adenoid cystic carcinoma cells of salivary gland origin: an immunoelectron microscopic study

Irié¹,

Cheng²,

Kimura³

et al. 1998

Virchows Archiv

View full text Add to dashboard Cite

ACC3, a human adenoid cystic carcinoma cell system of salivary gland origin, is able to synthesize and secrete a large amount of basement membrane molecules in vitro. To define the ultrastructural secreting pathway of these molecules, we immunolocalized heparan sulphate proteoglycan (HSPG) in ACC3 for 7 days of culture. In the early stage of culture, the main compartments immunolabelled were rough endoplasmic reticulum (rER) and small secretory vesicles. From days 3 to 4 after plating, it was noticed that HSPG was localized in partially dilated spaces of the perinuclear, rER and Golgi cisternae and in lysosomes or those fused with multivesicular bodies and endosomes. On and after day 5, almost every Golgi apparatus showed marked dilatation of the cisternae and HSPG was immunolocalized in these dilated spaces. In the later stage of culture, autophagic vacuoles or secondary lysosomes, which were simultaneously labelled for HSPG and cathepsin D, were accumulated in the cytoplasm. HSPG deposition in the intercellular space was clearly demonstrated from day 1 and increased during the culture. The results indicate that ACC3 cells have an enhanced turnover cycle for HSPG: not only its biosynthesis but also degradation of both endogenous or exogenous HSPG. Such intracellular events may be reflected in the characteristic histology and biological behaviour of adenoid cystic carcinomas.

show abstract

“…Adenoid cystic carcinoma (ACC) arising in the human salivary gland is characterized histopathologically by cribriform structures which consist of two types of lumi~ nal structures: one consists of stromal pseudocysts surrounded by myoepithelioid cells and the other is composed of ductal mimics containing salivary material in their lumina [4,8,19,23,30]. Previous immunohistochemical studies using surgical material have shown that the stroma of ACC including the pseudocystic space contains basement membrane molecules: type IV collagen, laminin, heparan sulphate proteoglycan and entactin [1,6,10,32,33].…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis of basement membrane molecules by salivary adenoid cystic carcinoma cells: an immunofluorescence and confocal microscopic study

Cheng

Irié

Munakata

et al. 1995

Vichows Archiv A Pathol Anat

View full text Add to dashboard Cite

The biosynthesis of basement membrane molecules and fibronectin was studied in vitro in the two different human cell systems (ACC2 and ACC3) established from adenoid cystic carcinomas (ACC) of the salivary gland using immunofluorescence and confocal microscopy. When cells were attached and spread on dishes, fine granular immunofluorescence for type IV collagen, laminin, heparan sulphate proteoglycan, entactin, and fibronectin first appeared diffusely in the cytoplasm, and then changed in aggregation of coarse granules in the perinuclear area. With formation of colonies, these signals were present in the extracellular space, initially in the basal aspect of attached cells and consequently in the lateral intercellular space. After the cells formed a confluent monolayer, extracellular signals started to decrease in inverse proportion to the reappearance of intracellular ones. The results indicate that the parenchymal cells of ACC synthesize these five extracellular matrix molecules, secrete them into the extracellular milieu and remodel the extracellular deposits. It is suggested that the characteristic stromal architecture of ACC, represented by stromal pseudocysts, results from their own secretion of the basement membrane molecules and fibronectin.

show abstract

Adenoid cystic carcinoma of the minor salivary glands

Cited by 20 publications

References 24 publications

Management of Nasopharyngeal Salivary Gland Malignancy

Management of Nasopharyngeal Salivary Gland Malignancy

Intracellular transport of basement membrane-type heparan sulphate proteoglycan in adenoid cystic carcinoma cells of salivary gland origin: an immunoelectron microscopic study

Biosynthesis of basement membrane molecules by salivary adenoid cystic carcinoma cells: an immunofluorescence and confocal microscopic study

Contact Info

Product

Resources

About