Adenoid Cystic Carcinoma of the Lacrimal Gland: High Dose Adjuvant Proton Therapy to Improve Patients Outcomes

Lesueur, Paul; Rapeaud, E.; Marzi, Ludovic De; Goudjil, F.; Lévy, Christine; Galatoire, O.; Jacomet, P.V.; Dendale, R.; Calugaru, Valentin

doi:10.3389/fonc.2020.00135

Cited by 25 publications

(13 citation statements)

References 31 publications

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“…For sinonasal tumors (including 4 ACC patients) treated to the median dose of 70 Gy with IMRT, Madani et al ( 59 ) also found non-negligible radiation-induced toxicity with 14.1% of grade 3 mucositis, 5.1% of grade 3 dysphagia, 5.1% of grade 3 dermatitis, and three cases of asymptomatic radio-necrosis. Lesueur et al ( 60 ) evaluated that lachrymal ACC radiation therapy could be associated with brain radio-necrosis, bone exposure, radiation neuropathy, secondary glaucoma, and radiation neuropathy.…”

Section: Clinical Considerations On Acc Irradiation With Cirtmentioning

confidence: 99%

Biological Rationale and Clinical Evidence of Carbon Ion Radiation Therapy for Adenoid Cystic Carcinoma: A Narrative Review

et al. 2021

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Adenoid cystic carcinoma (ACC) is a rare, basaloid, epithelial tumor, arising mostly from salivary glands. Radiation therapy can be employed as a single modality for unresectable tumors, in an adjuvant setting after uncomplete resection, in case of high-risk pathological features, or for recurrent tumors. Due to ACC intrinsic radioresistance, high linear energy transfer (LET) radiotherapy techniques have been evaluated for ACC irradiation: while fast neutron therapy has now been abandoned due to toxicity concerns, charged particle beams such as protons and carbon ions are at present the beams used for hadron therapy. Carbon ion radiation therapy (CIRT) is currently increasingly used for ACC irradiation. The aim of this review is to describe the immunological, molecular and clinicopathological bases that support ACC treatment with CIRT, as well as to expose the current clinical evidence that reveal the advantages of using CIRT for treating ACC.

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Section: Clinical Considerations On Acc Irradiation With Cirtmentioning

confidence: 99%

Biological Rationale and Clinical Evidence of Carbon Ion Radiation Therapy for Adenoid Cystic Carcinoma: A Narrative Review

et al. 2021

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“…particle therapy: satisfactory outcomes in ACC of the lacrimal gland with proton and heavy ion radiation 300 301 302 303 …”

Section: Tumors Of the Orbit 2 201 233mentioning

confidence: 99%

“…Partikelbestrahlung: Protonen- und Schwerionenbestrahlung mit befriedigendem Erfolg bei ACC der Tränendrüse 300 301 302 303 …”

Section: 2121bösartige Tumoren Der Tränendrüse Epithelialen Ursprungsunclassified

Seltene Erkrankungen der Orbita

Kisser

Heichel²,

Glien

2021

Laryngorhinootologie

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ZusammenfassungDieser Übersichtsartikel stellt eine Zusammenstellung seltener Erkrankungen der Orbita dar. Es werden angeborene Fehlbildungen und strukturelle Läsionen, entzündliche Erkrankungen, gutartige und bösartige epitheliale sowie nicht epitheliale Tumoren erörtert. Da in der Orbita zahlreiche Gewebetypen auf engstem Raum beieinanderliegen, kommen dort besonders viele Erkrankungen vor, sodass der Vollständigkeit und dem Tiefgang bei den einzelnen Abhandlungen natürliche Grenzen gesetzt sind. Die Kapitel beinhalten eine Übersicht über das jeweilige klinische Erscheinungsbild, wichtige Stichpunkte zur Diagnostik, Therapie und gegebenenfalls zur Prognose der Erkrankung. Dabei wurde versucht, die besonders charakteristischen Merkmale der einzelnen Erkrankungen herauszuarbeiten, sodass trotz der kurzen Darstellung die relevanten Aspekte enthalten sind.

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“…Proton therapy has also been used with some success in case reports and small retrospective studies for treating cutaneous ACC of the cavernous sinus [ 22 ], eyelid [ 23 ], lacrimal gland [ 24 ], and nasolacrimal duct [ 25 ] with acceptable toxicity. Larger series are needed to determine the disease control rates and toxicity rates for comparison with other modalities.…”

Section: Adenoid Cystic Carcinomamentioning

confidence: 99%

The Role of Particle Therapy in Adenoid Cystic Carcinoma and Mucosal Melanoma of the Head and Neck

Ebner

Malouff

Frank

et al. 2021

International Journal of Particle Therapy

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Particle irradiation is suitable for resistant histologies owing to a combination of improved dose delivery with potential radiobiologic advantages in high linear energy transfer radiation. Within the head and neck, adenoid cystic carcinoma and mucosal melanoma are two such histologies, being radioresistant and lying closely proximal to critical structures. Here, we review the use of particle irradiation for adenoid cystic carcinoma and mucosal melanoma of the head and neck.

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Adenoid Cystic Carcinoma of the Lacrimal Gland: High Dose Adjuvant Proton Therapy to Improve Patients Outcomes

Cited by 25 publications

References 31 publications

Biological Rationale and Clinical Evidence of Carbon Ion Radiation Therapy for Adenoid Cystic Carcinoma: A Narrative Review

Biological Rationale and Clinical Evidence of Carbon Ion Radiation Therapy for Adenoid Cystic Carcinoma: A Narrative Review

Seltene Erkrankungen der Orbita

The Role of Particle Therapy in Adenoid Cystic Carcinoma and Mucosal Melanoma of the Head and Neck

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