Adenoid cystic carcinoma of the breast: Utility of immunocytochemical study with collagen IV on fine-needle aspiration

Quinodoz, Ildiko Szalay; Berger, Sophie Diebold; Schäfer, Peter; Remadi, Sami

doi:10.1002/(sici)1097-0339(199705)16:5<442::aid-dc11>3.0.co;2-j

Cited by 12 publications

(7 citation statements)

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“…CS very often mimics the features of ACC in the breast and demonstrates similar spherical globules admixed with benign ductal epithelial and myoepithelial cells; however, it usually does not form a mass and is limited in extent, involving only a few ducts . In contrast to the three‐dimensional cell clusters with high nuclear‐to‐cytoplasmic ratios seen in ACC, CS yields cells arranged as two‐dimensional sheets with lower nuclear‐to‐cytoplasmic ratios . The naked nuclei of ACC are round and resemble those present in the three‐dimensional clusters, whereas bipolar naked nuclei are present in CS .…”

Section: Discussionmentioning

confidence: 90%

“…In this study, cell block material was prepared from each aspirate but not stained with immunohistochemical stains. In the study of Szalay et al, immunohistochemical staining for cytokeratin, epithelial membrane antigen, collagen IV, and alpha actin smooth muscle was performed on smears and histological sections obtained by excisional biopsy . To the best of our knowledge, this is the first case of breast ACC diagnosed on the basis of CD117 immunohistochemical staining of FNAC cell block material.…”

Section: Discussionmentioning

confidence: 93%

“…ACC of the breast is uncommon, accounting for 0.1% of all breast cancers . It has favorable biological characteristics and an excellent prognosis .…”

Section: Discussionmentioning

confidence: 99%

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Diagnosis of adenoid cystic carcinoma of the breast using fine‐needle aspiration cytology: A case report and review of the literature

Ilkay

Gozde

Sarıca

et al. 2015

Diagnostic Cytopathology

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Adenoid cystic carcinoma (ACC) of the breast is a rare variant of breast malignancy and is associated with an excellent prognosis. ACC accounts for 0.1% of all breast carcinomas. It has favorable biological characteristics and an excellent prognosis. A 77-year-old woman presented with a lump in the right breast. Ultrasonography and mammography showed a 12-mm, well-defined, lobulated mass in the retroareolar region of the right breast. The lump was diagnosed as ACC on the basis of immunohistochemical staining results for c-kit (CD117), muscle-specific actin, p63, estrogen receptor, and progesterone receptor using a fine-needle aspiration cytology (FNAC) specimen. This diagnosis was subsequently confirmed by excision biopsy. To the best of our knowledge, this is the first case of ACC of the breast to date to be diagnosed on the basis of immunohistochemical staining of an FNAC cell block material. From our experience, we recommend the usage of cell block material for immunohistochemical studies to accurately diagnose ACC of the breast.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 93%

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Diagnosis of adenoid cystic carcinoma of the breast using fine‐needle aspiration cytology: A case report and review of the literature

Ilkay

Gozde

Sarıca

et al. 2015

Diagnostic Cytopathology

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“…In contrast to the three-dimensional cell clusters with high nuclear-to-cytoplasmic ratios seen in ACC, CS yields cells arranged as two-dimensional sheets with lower nuclear-to-cytoplasmic ratios. 4,14,16,17 The naked nuclei of ACC are round and resemble those present in the three-dimensional clusters, whereas bipolar naked nuclei are present in CS. 10 Clinically, CS is detected incidentally, whereas ACC produces a palpable mass, though an isolated case of palpable CS has been described.…”

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confidence: 98%

Adenoid cystic carcinoma of the breast diagnosed by fine‐needle aspiration

Saqi

Mercado

Hamele‐Bena

2004

Diagnostic Cytopathology

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Fine-needle aspiration cytology remains a useful tool for preoperative diagnosis of breast lesions. We describe a case of adenoid cystic carcinoma (ACC) of the breast detected by ultrasound-guided fine-needle aspiration (FNA). Subsequent histopathology corroborated the diagnosis. ACC is a rare but distinctive neoplasm of the breast that can be accurately diagnosed by FNA. Its infrequent presentation, favorable prognosis, and relatively conservative management in the breast prompt us to reinforce its features.

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“…As one of the important methods for preoperative qualitative diagnosis of breast cancer, FNAC has a similar effect to pathological examination, and its diagnostic value has been generally recognized. However, for breast adenoid cystic carcinoma, only a few case reports or a small number of sample studies describe the application of FNAC in ACC diagnosis (6,(17)(18)(19)(20)(21)(22). The diagnostic cytological findings of ACC are rarely described.…”

Section: Discussionmentioning

confidence: 99%

Management of Adenoid Cystic Carcinoma of the Breast: A Single-Institution Study

et al. 2021

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ObjectiveThe purpose of our study was to analyze the clinicopathologic features and surgical and oncological outcomes of adenoid cystic carcinoma (ACC) of the breast and to provide the basis for a clinical therapeutic schedule.MethodsA total of 14 patients with primary breast adenoid cystic carcinoma treated at Cancer Hospital of the Chinese Academy of Medical Sciences from January 2000 to December 2017 were included. Data on clinical presentation, treatment strategy, and outcome, as well as the pathological features of ACC, were reviewed and analyzed.ResultsFourteen patients were diagnosed with ACC of the breast, out of 23205 total patients treated for breast cancer (0.06%). All but three patients were postmenopausal, with a median age at diagnosis of 60.5 years (range, 39–73 years). The most common clinical presentation was a palpable mass (85.7%), and the imaging characteristics of all patients on color Doppler ultrasound and mammography were nonspecific. Six patients (42.9%) were suspected of having ACC by fine-needle aspiration cytology (FNAC) and were confirmed by postoperative histology and immunohistochemistry. All 14 patients underwent surgery, and no patient had a positive lymph node status. Median tumor size was 1.75 cm (range, 1–3 cm). Eight/14 (57.1%) patients were hormone receptor negative (HR−) and HER-2/neu (−) (HER2−). The remaining patients were hormone receptor positive (HR+). There was no significant difference in clinicopathological characteristics between the HR+ group and the HR- group (P>0.05). The mean follow-up period was 57 months. Local recurrence occurred in 14.3% of patients, 1.7% of patients had distant metastasis, all patients with local recurrence or distant metastasis were in the HR (-) group, and all patients were alive at the last follow-up.ConclusionACC of the breast cannot be simply summarized as triple-negative breast cancer because it also includes a small number of hormone receptor-positive breast cancers. Establishing a preoperative diagnosis is difficult on the basis of clinical imaging examination, FNAC may be useful tool in the diagnosis. the final diagnosis can only be assessed based on the results of the histopathological and immunohistochemical examination. Breast-conserving surgery may be an alternative treatment strategy, and axillary lymph node dissection or sentinel node biopsy may not be necessary in some cases.

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Adenoid cystic carcinoma of the breast: Utility of immunocytochemical study with collagen IV on fine-needle aspiration

Cited by 12 publications

References 12 publications

Diagnosis of adenoid cystic carcinoma of the breast using fine‐needle aspiration cytology: A case report and review of the literature

Diagnosis of adenoid cystic carcinoma of the breast using fine‐needle aspiration cytology: A case report and review of the literature

Adenoid cystic carcinoma of the breast diagnosed by fine‐needle aspiration

Management of Adenoid Cystic Carcinoma of the Breast: A Single-Institution Study

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